UniProt Q9K2N0
Beta-lactamase class B VIM-2 (Q9K2N0)
Beta-lactamase class B VIM-2 (UniProt Q9K2N0), EC 3.5.2.6: 98 experimental structures on GenesisL1, 60 ligands bound, 10 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q9K2N0
- Protein
- Beta-lactamase class B VIM-2
- EC
- 3.5.2.6
- Experimental structures
- 98
- Predicted models
- 0
- Ligands
- 60
- Pockets
- 10 · 8 records with a druggable one
Structures
98 records of Q9K2N0 in the MolNFT archive: 98 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1KO2 | VIM-2, a Zn-beta-lactamase from Pseudomonas aeruginosa with an oxidized Cys (cysteinesulfonic) | x-ray diffraction | A | — | — |
| 1KO2 | Vim-2, a zn-beta-lactamase from pseudomonas aeruginosa with an oxidized cys (cysteinesulfonic) | x-ray diffraction | A | — | — |
| 1KO3 | VIM-2, a Zn-beta-lactamase from Pseudomonas aeruginosa with Cys221 reduced | x-ray diffraction | A | — | — |
| 1KO3 | Vim-2, a zn-beta-lactamase from pseudomonas aeruginosa with CYS221 reduced | x-ray diffraction | A | — | — |
| 4BZ3 | Crystal structure of the metallo-beta-lactamase VIM-2 | x-ray diffraction | A, B | — | — |
| 4BZ3 | Crystal structure of the metallo-beta-lactamase vim-2 | x-ray diffraction | A, B | — | — |
| 4C1D | Crystal structure of the metallo-beta-lactamase VIM-2 with L-captopril | x-ray diffraction | A, B | — | — |
| 4C1D | Crystal structure of the metallo-beta-lactamase vim-2 with L-captopril | x-ray diffraction | A, B | — | — |
| 4C1E | Crystal structure of the metallo-beta-lactamase VIM-2 with D-captopril | x-ray diffraction | A, B | — | — |
| 4C1E | Crystal structure of the metallo-beta-lactamase vim-2 with D-captopril | x-ray diffraction | A, B | — | — |
| 4NQ2 | Structure of Zn(II)-bound metallo-beta-lactamse VIM-2 from Pseudomonas aeruginosa | x-ray diffraction | A | — | — |
| 4NQ2 | Structure of ZN(II)-bound metallo-beta-lactamse vim-2 from pseudomonas aeruginosa | x-ray diffraction | A | — | — |
| 4PVO | Crystal Structure of VIM-2 metallo-beta-lactamase in complex with ML302 and ML302F | x-ray diffraction | A, B | — | — |
| 4PVO | Crystal structure of vim-2 metallo-beta-lactamase in complex with ML302 and ML302F | x-ray diffraction | A, B | — | — |
| 4PVT | Crystal Structure of VIM-2 metallo-beta-lactamase in complex with ML302F | x-ray diffraction | A, B | — | — |
| 4PVT | Crystal structure of vim-2 metallo-beta-lactamase in complex with ML302F | x-ray diffraction | A, B | — | — |
| 4UA4 | Structure of the VIM-2 Metallo-beta-Lactamase in Complex with a Bisthiazolidine Inhibitor | x-ray diffraction | A, B | — | — |
| 4UA4 | Structure of the vim-2 metallo-beta-lactamase in complex with a bisthiazolidine inhibitor | x-ray diffraction | A, B | — | — |
| 5ACU | VIM-2-NAT, Discovery of novel inhibitor scaffolds against the metallo- beta-lactamase VIM-2 by SPR… | x-ray diffraction | A | — | — |
| 5ACU | Vim-2-nat, discovery of novel inhibitor scaffolds against the metallo-beta-lactamase vim-2 by spr… | x-ray diffraction | A | — | — |
| 5ACV | VIM-2-OX, Discovery of novel inhibitor scaffolds against the metallo- beta-lactamase VIM-2 by SPR… | x-ray diffraction | A, B | — | — |
| 5ACV | Vim-2-ox, discovery of novel inhibitor scaffolds against the metallo- beta-lactamase vim-2 by spr… | x-ray diffraction | A, B | — | — |
| 5ACW | VIM-2-1, Discovery of novel inhibitor scaffolds against the metallo- beta-lactamase VIM-2 by SPR… | x-ray diffraction | A, B | — | — |
| 5ACW | Vim-2-1, discovery of novel inhibitor scaffolds against the metallo- beta-lactamase vim-2 by spr… | x-ray diffraction | A, B | — | — |
| 5ACX | VIM-2-2, Discovery of novel inhibitor scaffolds against the metallo- beta-lactamase VIM-2 by SPR… | x-ray diffraction | A, B | — | — |
| 5ACX | Vim-2-2, discovery of novel inhibitor scaffolds against the metallo- beta-lactamase vim-2 by spr… | x-ray diffraction | A, B | — | — |
| 5FQC | Crystal structure of the metallo-beta-lactamase VIM-2 with 2C | x-ray diffraction | A, B | ZN, OK3 | 2 (best 0.73) |
| 5FQC | Crystal structure of the metallo-beta-lactamase vim-2 with 2C | x-ray diffraction | A, B | — | — |
| 5K48 | Vim-2 metallo beta lactamase in complex with 3-(mercaptomethyl)-[1,1'- biphenyl]-4-carboxylic acid | x-ray diffraction | A, B | S5Z, ZN | — |
| 5LCA | VIM-2 metallo-beta-lactamase in complex with 3-oxo-2-(3-(trifluoromethyl)phenyl)isoindoline-4-carbox… | x-ray diffraction | A | ZN, B06 | — |
| 5LCA | Vim-2 metallo-beta-lactamase in complex with 3-oxo-2-(3… | x-ray diffraction | A | ZN, B06 | — |
| 5LCF | Vim-2 metallo-beta-lactamase in complex with 3-oxo-2- phenylisoindoline-4-carboxylic acid (compound… | x-ray diffraction | A | ZN, 6TJ | — |
| 5LCH | VIM-2 metallo-beta-lactamase in complex with (S)-1-allyl-2-(3-methoxyphenyl)-3-oxoisoindoline-4-carb… | x-ray diffraction | A | ZN, 6TU | — |
| 5LCH | Vim-2 metallo-beta-lactamase in complex with (S)-1-allyl-2-(3… | x-ray diffraction | A | ZN, 6TU | — |
| 5LE1 | Vim-2 metallo-beta-lactamase in complex with 2-(2-chloro-6… | x-ray diffraction | A | ZN, 6UW | — |
| 5LM6 | Vim-2 metallo-beta-lactamase in complex with 2-(3-fluoro-4… | x-ray diffraction | B, A | ZN, H32 | — |
| 5MXQ | Crystal Structure of the Acquired VIM-2 Metallo-beta-Lactamase in Complex with ANT-90 Inhibitor | x-ray diffraction | A | ZN, U8K, CL | — |
| 5MXQ | Crystal structure of the acquired vim-2 metallo-beta-lactamase in complex with ant-90 inhibitor | x-ray diffraction | A | ZN, U8K, CL | — |
| 5MXR | Crystal Structure of the Acquired VIM-2 Metallo-beta-Lactamase in Complex with ANT-330 Inhibitor | x-ray diffraction | A | ZN, JTY | — |
| 5MXR | Crystal structure of the acquired vim-2 metallo-beta-lactamase in complex with ant-330 inhibitor | x-ray diffraction | A | ZN, JTY | — |
| 5N4S | VIM-2 metallo-beta-lactamase in complex with ((S)-3-mercapto-2-methylpropanoyl)-D-tryptophan… | x-ray diffraction | A, B | ZN, R38 | — |
| 5N4S | Vim-2 metallo-beta-lactamase in complex with ((S)-3-mercapto-2- methylpropanoyl)-D-tryptophan… | x-ray diffraction | A, B | ZN, R38 | — |
| 5N4T | VIM-2 metallo-beta-lactamase in complex with ((S)-3-mercapto-2-methylpropanoyl)-L-tryptophan… | x-ray diffraction | A, B | ZN, R59, BEZ | — |
| 5N4T | Vim-2 metallo-beta-lactamase in complex with ((S)-3-mercapto-2- methylpropanoyl)-L-tryptophan… | x-ray diffraction | A, B | ZN, R59, BEZ | — |
| 5NHZ | VIM-2_10b. Metallo-beta-Lactamase Inhibitors by Bioisosteric Replacement: Preparation, Activity and… | x-ray diffraction | A, B | ZN, 8XZ, CL, PO4, SO4 | 1 (best 0.72) |
| 5NHZ | Vim-2_10B. metallo-beta-lactamase inhibitors by bioisosteric replacement: preparation, activity and… | x-ray diffraction | A, B | ZN, 8XZ, CL, PO4, SO4 | — |
| 5NI0 | VIM-2_10c. Metallo-beta-Lactamase Inhibitors by Bioisosteric Replacement: Preparation, Activity and… | x-ray diffraction | A, E | ZN, 8XW | — |
| 5NI0 | Vim-2_10C. metallo-beta-lactamase inhibitors by bioisosteric replacement: preparation, activity and… | x-ray diffraction | A, E | ZN, 8XW | — |
| 5Y6D | Vim-2 metallo-beta-lactamase in complex with (R)-2-(4-fluorophenyl)-2… | x-ray diffraction | A, B, C, D | ZN, 8PL | — |
| 5Y6E | Vim-2 metallo-beta-lactamase in complex with (R)-2-(4-hydroxyphenyl)… | x-ray diffraction | A, B | ZN, 8PO | — |
| 5YD7 | Crystal structure of vim-2 metallo-beta-lactamase | x-ray diffraction | A, B | ZN | — |
| 6DD0 | Crystal structure of vim-2 complexed with compound 8 | x-ray diffraction | A, B | ZN, P9T | — |
| 6DD1 | Crystal structure of vim-2 complexed with compound 14 | x-ray diffraction | A, B | ZN, M3Q | — |
| 6HF5 | Crystal Structure of the Acquired VIM-2 Metallo-beta-Lactamase in Complex with ANT-431 Inhibitor | x-ray diffraction | A | ZN, G1N | — |
| 6HF5 | Crystal structure of the acquired vim-2 metallo-beta-lactamase in complex with ant-431 inhibitor | x-ray diffraction | A | ZN, G1N | — |
| 6J8R | Metallo-Beta-Lactamase VIM-2 in complex with Dual MBL/SBL Inhibitor MS01 | x-ray diffraction | A | ZN, BHU | 1 (best 0.55) |
| 6J8R | Metallo-beta-lactamase vim-2 in complex with dual MBL/SBL inhibitor MS01 | x-ray diffraction | A | ZN, BHU | — |
| 6JN6 | Metallo-Beta-Lactamase VIM-2 in complex with Dual MBL/SBL Inhibitor MS19 | x-ray diffraction | A, B | ZN, BY0 | — |
| 6JN6 | Metallo-beta-lactamase vim-2 in complex with dual MBL/SBL inhibitor MS19 | x-ray diffraction | A, B | ZN, BY0 | — |
| 6KW1 | The structure of the metallo-beta-lactamase VIM-2 in complex with a triazolylthioacetamide 1b | x-ray diffraction | A, B | ZN, CL, MG, NA, 9RX | — |
38 records more on the page itself.
Ligands
- ZN · Zinc ion · in 70 records
- CL · Chloride ion · in 12 records
- OH · Hydroxide ion · in 6 records
- MG · Magnesium ion · in 5 records
- IOD · Iodide ion · in 4 records
- NA · Sodium ion · in 4 records
- 6TU · (1~{S})-2-(3-methoxyphenyl)-3-oxidanylidene-1-prop-2-enyl-1~{H}-isoindole-4-carboxylic acid · in 2 records
- 8XW · [(2~{R})-1-ethanoylsulfanyl-6-phenyl-hexan-2-yl]phosphonic acid · in 2 records
- 8XZ · [(2~{R})-1-ethanoylsulfanyl-5-phenyl-pentan-2-yl]phosphonic acid · in 2 records
- 9NW · 2,5-bis(chloranyl)-~{N}-[[5-[(cyclohexylamino)methyl]-2~{H}-1,2,3-triazol-4-yl]methyl]benzenesulfonamide · in 2 records
- 9OB · ~{N}-[[5-[[(phenylmethyl)amino]methyl]-1~{H}-1,2,3-triazol-4-yl]methyl]benzenesulfonamide · in 2 records
- 9RX · 2-[3-[2-(1H-benzimidazol-2-ylamino)-2-oxidanylidene-ethyl]sulfanyl-1H-1,2,4-triazol-5-yl]benzoic acid · in 2 records
- B06 · 3-oxidanylidene-2-[3-(trifluoromethyl)phenyl]-1~{H}-isoindole-4-carboxylic acid · in 2 records
- BEZ · Benzoic acid · in 2 records
- BHU · [[(2S)-2-methyl-3-sulfanyl-propanoyl]amino]methylboronic acid · in 2 records
- BY0 · [(1S)-2-(1-benzofuran-3-yl)-1-[[(2S)-2-methyl-3-sulfanyl-propanoyl]amino]ethyl]boronic acid · in 2 records
- E1C · 2,5-diethyl-1-methyl-4-sulfamoyl-pyrrole-3-carboxylic acid · in 2 records
- FZX · 1-(phenylmethyl)imidazole-2-carboxylic acid · in 2 records
- G1N · 5-(pyridin-3-ylsulfonylamino)-1,3-thiazole-4-carboxylic acid · in 2 records
- HL3 · 1-[(2~{R})-butan-2-yl]imidazole-2-carboxylic acid · in 2 records
- JTY · 5-(phenylsulfonylamino)-1,3-thiazole-4-carboxylic acid · in 2 records
- PO4 · Phosphate ion · in 2 records
- QZH · (5~{Z})-2-[1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-5-(4-oxidanylbutylidene)-2~{H}-1,3-thiazole-4-carboxylic acid · in 2 records
- R38 · (2~{R})-3-(1~{H}-indol-3-yl)-2-[[(2~{S})-2-methyl-3-sulfanyl-propanoyl]amino]propanoic acid · in 2 records
- R59 · (2~{S})-3-(1~{H}-indol-3-yl)-2-[[(2~{S})-2-methyl-3-sulfanyl-propanoyl]amino]propanoic acid · in 2 records
- R9K · 3-(2-chlorophenyl)-7-methyl-1~{H}-indole-2-carboxylic acid · in 2 records
- SO4 · Sulfate ion · in 2 records
- U8K · 3-(phenylsulfonylamino)pyridine-2-carboxylic acid · in 2 records
- 5ZU · 2-azanyl-5-(thiophen-2-ylmethyl)-1,3-thiazole-4-carboxylic acid · in 1 record
- 6TJ · 3-oxidanylidene-2-phenyl-1~{H}-isoindole-4-carboxylic acid · in 1 record
Elsewhere
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