UniProt Q9HBE5
Interleukin-21 receptor (Q9HBE5)
Interleukin-21 receptor (UniProt Q9HBE5): 9 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 78 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9HBE5
- Protein
- Interleukin-21 receptor
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 78 · 6 records with a druggable one
Structures
10 records of Q9HBE5 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3TGX | IL-21:IL21R complex | x-ray diffraction | A, C, E, G, I, K, M, O | NAG, MAN, FUL, FUC, NI, SO4 | 20 (best 0.70) |
| 3TGX | Il-21:IL21R complex | x-ray diffraction | A, C, E, G, I, K, M, O | NAG, MAN, FUL, FUC, NI, SO4 | 20 (best 0.70) |
| 4NZD | Interleukin 21 receptor | x-ray diffraction | A, B, C | NAG, FUC, MAN, NA, CL | 9 (best 0.72) |
| 4NZD | Interleukin 21 receptor | x-ray diffraction | A, B, C | NAG, FUC, MAN, NA, CL | 9 (best 0.72) |
| 6PLH | FAB fragment complexed with C-mannosylated tryptophan peptide | x-ray diffraction | C | MAN | 1 (best 0.36) |
| 6PLH | Fab fragment complexed with C-mannosylated tryptophan peptide | x-ray diffraction | C | MAN | — |
| 7KQ7 | Crystal structure of IL21R in complex with an antibody Fab fragment | x-ray diffraction | B | — | 3 (best 0.57) |
| 7KQ7 | Crystal structure of IL21R in complex with an antibody Fab fragment | x-ray diffraction | B | — | — |
| 8ENT | Interleukin-21 signaling complex with IL-21R and IL-2Rg | x-ray diffraction | B, E, H, K | NAG | 16 (best 0.72) |
| Q9HBE5 | AlphaFold monomer V2.0 prediction for interleukin-21 receptor (Q9HBE5) | predicted | A | — | — |
Ligands
- MAN · alpha-D-mannopyranose · in 6 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 5 records
- FUC · alpha-L-fucopyranose · in 4 records
- CL · Chloride ion · in 2 records
- FUL · beta-L-fucopyranose · in 2 records
- NA · Sodium ion · in 2 records
- NI · Nickel (II) ion · in 2 records
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 8ENT chain H against the predicted model Q9HBE5: TM-score 0.99, RMSD 0.61 Å
- 8ENT chain B against the predicted model Q9HBE5: TM-score 0.99, RMSD 0.62 Å
- 3TGX chain C against the predicted model Q9HBE5: TM-score 0.99, RMSD 0.63 Å
- 3TGX chain C against the predicted model Q9HBE5: TM-score 0.99, RMSD 0.63 Å
- 3TGX chain A against the predicted model Q9HBE5: TM-score 0.99, RMSD 0.63 Å
- 3TGX chain A against the predicted model Q9HBE5: TM-score 0.99, RMSD 0.63 Å
- 8ENT chain K against the predicted model Q9HBE5: TM-score 0.98, RMSD 0.67 Å
- 8ENT chain E against the predicted model Q9HBE5: TM-score 0.98, RMSD 0.69 Å
- 3TGX chain E against the predicted model Q9HBE5: TM-score 0.98, RMSD 0.74 Å
- 3TGX chain E against the predicted model Q9HBE5: TM-score 0.98, RMSD 0.74 Å
Elsewhere
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