UniProt Q9HAN9
Nicotinamide mononucleotide adenylyl transferase (Q9HAN9)
Nicotinamide mononucleotide adenylyl transferase (UniProt Q9HAN9), EC 2.7.7.1: 11 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 63 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9HAN9
- Protein
- Nicotinamide mononucleotide adenylyl transferase
- EC
- 2.7.7.1
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 63 · 7 records with a druggable one
Structures
12 records of Q9HAN9 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1GZU | Crystal Structure of Human Nicotinamide Mononucleotide Adenylyltransferase in Complex with NMN | x-ray diffraction | A, B, C | NMN | 3 (best 0.73) |
| 1GZU | Crystal structure of human nicotinamide mononucleotide adenylyltransferase in complex with nmn | x-ray diffraction | A, B, C | — | — |
| 1KKU | Crystal structure of nuclear human nicotinamide mononucleotide adenylyltransferase | x-ray diffraction | A | — | 2 (best 0.68) |
| 1KKU | Crystal structure of nuclear human nicotinamide mononucleotide adenylyltransferase | x-ray diffraction | A | — | — |
| 1KQN | Crystal structure of NMN/NaMN adenylyltransferase complexed with NAD | x-ray diffraction | A, B, C, D, E, F | NAD, XE | 13 (best 0.83) |
| 1KQN | Crystal structure of NMN/NAMN adenylyltransferase complexed with NAD | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1KQO | Crystal structure of NMN/NaMN adenylyltransferase complexed with deamido-NAD | x-ray diffraction | A, B, C, D, E, F | DND | 13 (best 0.84) |
| 1KQO | Crystal structure of NMN/NAMN adenylyltransferase complexed with deamido-NAD | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1KR2 | Crystal structure of human NMN/NAMN adenylyl transferase complexed with tiazofurin adenine… | x-ray diffraction | A, B, C, D, E, F | TAD | 16 (best 0.84) |
| 1KR2 | Crystal structure of human NMN/NAMN adenylyl transferase complexed with tiazofurin adenine… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 8QE8 | Structure of the non-canonical CTLH E3 substrate receptor WDR26 bound to NMNAT1 substrate | electron microscopy | 4, 5, 6, 3, 2, 1 | NMN | 15 (best 0.83) |
| Q9HAN9 | AlphaFold monomer V2.0 prediction for NICOTINAMIDE/NICOTINIC acid mononucleotide… | predicted | A | — | 1 (best 0.75) |
Ligands
Experiment against prediction
- 1KR2 chain A against the predicted model Q9HAN9: TM-score 0.99, RMSD 0.98 Å
- 1KR2 chain A against the predicted model Q9HAN9: TM-score 0.99, RMSD 0.98 Å
- 1KR2 chain E against the predicted model Q9HAN9: TM-score 0.99, RMSD 0.96 Å
- 1KR2 chain E against the predicted model Q9HAN9: TM-score 0.99, RMSD 0.96 Å
- 1KR2 chain F against the predicted model Q9HAN9: TM-score 0.98, RMSD 0.96 Å
- 1KR2 chain F against the predicted model Q9HAN9: TM-score 0.98, RMSD 0.96 Å
- 1KQN chain B against the predicted model Q9HAN9: TM-score 0.98, RMSD 0.97 Å
- 1KQN chain B against the predicted model Q9HAN9: TM-score 0.98, RMSD 0.97 Å
- 1KQN chain A against the predicted model Q9HAN9: TM-score 0.98, RMSD 1.00 Å
- 1KQN chain A against the predicted model Q9HAN9: TM-score 0.98, RMSD 1.00 Å
Elsewhere
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