MolNFT v1 · #12569 · protein
Crystal structure of nuclear human nicotinamide mononucleotide adenylyltransferase
1KKU: “Crystal structure of nuclear human nicotinamide mononucleotide adenylyltransferase”. X-ray diffraction, 2 pockets (best druggability 0.68). MolNFT v1 #12569 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1KKU
- Type
- protein
- Length
- 216 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nicotinamide mononucleotide adenylyltransferase
- EC
- 2.7.7.1
- UniProt
- Q9HAN9
- Pockets
- 2 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nicotinamide mononucleotide adenylyltransferase (EC 2.7.7.1) | protein | 216 | 46% helix, 19% strand | Q9HAN9 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 586 | 0.68 | 0.77 | 52 | empty |
| 2 | 62 | 0.29 | 0.74 | 17 | empty |
Compared structures
- 1KKU · Crystal structure of nuclear human nicotinamide mononucleotide adenylyltransferase · the same entry in another collection · chain A against A, TM-score 1.00
- Q9HAN9 · AlphaFold monomer V2.0 prediction for NICOTINAMIDE/NICOTINIC acid mononucleotide… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HAN9
- Elsewhere: RCSB PDB 1KKU · PDBe 1KKU · UniProt Q9HAN9
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