UniProt Q9H3S7
Tyrosine-protein phosphatase non-receptor type 23 (Q9H3S7)
Tyrosine-protein phosphatase non-receptor type 23 (UniProt Q9H3S7), EC 3.1.3.48: 21 experimental structures and 1 predicted model on GenesisL1, 70 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9H3S7
- Protein
- Tyrosine-protein phosphatase non-receptor type 23
- EC
- 3.1.3.48
- Experimental structures
- 21
- Predicted models
- 1
- Pockets
- 70 · 7 records with a druggable one
Structures
22 records of Q9H3S7 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3RAU | Crystal structure of the HD-PTP Bro1 domain | x-ray diffraction | A, B | — | — |
| 3RAU | Crystal structure of the hd-ptp BRO1 domain | x-ray diffraction | A, B | — | — |
| 5CRU | Crystal structure of the Bro domain of HD-PTP | x-ray diffraction | A, B, C, D | — | 15 (best 0.81) |
| 5CRU | Crystal structure of the bro domain of hd-ptp | x-ray diffraction | A, B, C, D | — | — |
| 5CRV | Crystal structure of the bro domain of hd-ptp in a complex with the core region of STAM2 | x-ray diffraction | A, B | — | — |
| 5LM1 | Crystal Structure of HD-PTP phosphatase in complex with UBAP1 | x-ray diffraction | A | — | — |
| 5LM1 | Crystal structure of hd-ptp phosphatase in complex with UBAP1 | x-ray diffraction | A | — | — |
| 5LM2 | Crystal Structure of HD-PTP phosphatase | x-ray diffraction | A, B | — | 4 (best 0.53) |
| 5LM2 | Crystal structure of hd-ptp phosphatase | x-ray diffraction | A, B | — | — |
| 5MJY | Crystal structure of the His Domain Protein Tyrosine Phosphatase (HD-PTP/PTPN23) Bro1 domain (SARA… | x-ray diffraction | A, B, C, D | — | — |
| 5MJY | Crystal structure of the his domain protein tyrosine phosphatase (hd- PTP/PTPN23) BRO1 domain (sara… | x-ray diffraction | A, B, C, D | — | — |
| 5MJZ | Crystal structure of the His Domain Protein Tyrosine Phosphatase (HD-PTP/PTPN23) Bro1 domain (Apo… | x-ray diffraction | A, B | — | 8 (best 0.73) |
| 5MJZ | Crystal structure of the his domain protein tyrosine phosphatase (hd- PTP/PTPN23) BRO1 domain (apo… | x-ray diffraction | A, B | — | — |
| 5MK0 | Crystal structure of the His Domain Protein Tyrosine Phosphatase (HD-PTP/PTPN23) Bro1 domain… | x-ray diffraction | A, C | — | 10 (best 0.78) |
| 5MK0 | Crystal structure of the his domain protein tyrosine phosphatase (hd- PTP/PTPN23) BRO1 domain… | x-ray diffraction | A, C | — | — |
| 5MK1 | Crystal structure of the His Domain Protein Tyrosine Phosphatase (HD-PTP/PTPN23) Bro1 domain… | x-ray diffraction | A, B, C, D | — | 15 (best 0.76) |
| 5MK1 | Crystal structure of the his domain protein tyrosine phosphatase (hd- PTP/PTPN23) BRO1 domain… | x-ray diffraction | A, B, C, D | — | — |
| 5MK2 | Crystal structure of the His Domain Protein Tyrosine Phosphatase (HD-PTP/PTPN23) Bro1 domain… | x-ray diffraction | A, B | — | 6 (best 0.70) |
| 5MK2 | Crystal structure of the his domain protein tyrosine phosphatase (hd- PTP/PTPN23) BRO1 domain… | x-ray diffraction | A, B | — | — |
| 5MK3 | Crystal structure of the His Domain Protein Tyrosine Phosphatase (HD-PTP/PTPN23) Bro 1 domain… | x-ray diffraction | A, B, C, D | — | — |
| 5MK3 | Crystal structure of the his domain protein tyrosine phosphatase (hd- PTP/PTPN23) bro 1 domain… | x-ray diffraction | A, B, C, D | — | — |
| Q9H3S7 | AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 23 (Q9H3S7) | predicted | A | — | 12 (best 0.59) |
Experiment against prediction
- 5MK1 chain D against the predicted model Q9H3S7: TM-score 1.00, RMSD 0.49 Å
- 5MK1 chain D against the predicted model Q9H3S7: TM-score 1.00, RMSD 0.49 Å
- 5MK2 chain B against the predicted model Q9H3S7: TM-score 0.99, RMSD 0.55 Å
- 5MK2 chain B against the predicted model Q9H3S7: TM-score 0.99, RMSD 0.55 Å
- 5CRU chain A against the predicted model Q9H3S7: TM-score 0.99, RMSD 0.58 Å
- 5CRU chain A against the predicted model Q9H3S7: TM-score 0.99, RMSD 0.58 Å
- 5MJZ chain B against the predicted model Q9H3S7: TM-score 0.99, RMSD 0.60 Å
- 5MJZ chain B against the predicted model Q9H3S7: TM-score 0.99, RMSD 0.60 Å
- 5MK2 chain A against the predicted model Q9H3S7: TM-score 0.99, RMSD 0.62 Å
- 5MK2 chain A against the predicted model Q9H3S7: TM-score 0.99, RMSD 0.62 Å
Elsewhere
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