MolNFT v1 · #127009 · protein
Crystal structure of the his domain protein tyrosine phosphatase (hd- PTP/PTPN23) BRO1 domain (apo structure)
5MJZ · Tyrosine-protein phosphatase non-receptor type 23: “Crystal structure of the his domain protein tyrosine phosphatase (hd- PTP/PTPN23) BRO1 domain (apo structure)”. X-ray diffraction, 8 pockets (best druggability 0.73). MolNFT v1…
- PDB
- 5MJZ
- Type
- protein
- Length
- 717 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase non-receptor type 23
- EC
- 3.1.3.48
- UniProt
- Q9H3S7
- Pockets
- 8 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 67% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) | protein | 361 | 66% helix, 2% strand | Q9H3S7 |
| B | Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) | protein | 356 | 67% helix, 3% strand | Q9H3S7 |
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 822 | 0.73 | 0.78 | 94 | empty |
| 2 | 120 | 0.55 | 0.83 | 27 | empty |
| 3 | 72 | 0.41 | 0.80 | 16 | empty |
| 4 | 124 | 0.39 | 0.74 | 25 | empty |
| 5 | 91 | 0.35 | 0.74 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 668 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 5MJZ · Crystal structure of the His Domain Protein Tyrosine Phosphatase (HD-PTP/PTPN23) Bro1… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9H3S7 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 23… · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H3S7
- Elsewhere: RCSB PDB 5MJZ · PDBe 5MJZ · UniProt Q9H3S7
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