MolNFT v1 · #125874 · protein
Crystal structure of hd-ptp phosphatase
5LM2 · Tyrosine-protein phosphatase non-receptor type 23: “Crystal structure of hd-ptp phosphatase”. X-ray diffraction, 4 pockets (best druggability 0.53). MolNFT v1 #125874 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5LM2
- Type
- protein
- Length
- 658 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase non-receptor type 23
- EC
- 3.1.3.48
- UniProt
- Q9H3S7
- Pockets
- 4 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 83% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) | protein | 318 | 85% helix, 0% strand | Q9H3S7 |
| B | Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) | protein | 340 | 82% helix, 0% strand | Q9H3S7 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 254 | 0.53 | 0.76 | 29 | empty |
| 2 | 71 | 0.37 | 0.78 | 17 | empty |
| 3 | 81 | 0.37 | 0.76 | 16 | empty |
| 4 | 81 | 0.33 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 704 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 22 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H3S7
- Elsewhere: RCSB PDB 5LM2 · PDBe 5LM2 · UniProt Q9H3S7
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