UniProt Q9H3H5
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (Q9H3H5)
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (UniProt Q9H3H5), EC 2.7.8.15: 12 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 58 pockets. Binding sites…
- UniProt
- Q9H3H5
- Protein
- UDP-N-acetylglucosamine--dolichyl-phosphate…
- EC
- 2.7.8.15
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 58 · 8 records with a druggable one
Structures
13 records of Q9H3H5 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5LEV | Crystal structure of human UDP-N-acetylglucosamine-dolichyl-phosphate… | x-ray diffraction | A | UNL | 3 (best 0.68) |
| 5LEV | Crystal structure of human udp-N-acetylglucosamine-dolichyl-phosphate… | x-ray diffraction | A | UNL | 3 (best 0.68) |
| 5O5E | Crystal structure of human UDP-N-acetylglucosamine-dolichyl-phosphate… | x-ray diffraction | A | P6L, 9LH, UNL | 3 (best 0.76) |
| 5O5E | Crystal structure of human udp-N-acetylglucosamine-dolichyl-phosphate… | x-ray diffraction | A | P6L, 9LH, UNL | 3 (best 0.76) |
| 6BW5 | Human GPT (DPAGT1) in complex with tunicamycin | x-ray diffraction | A, B, C, D | TUM, PGW | 20 (best 0.79) |
| 6BW5 | Human gpt (DPAGT1) in complex with tunicamycin | x-ray diffraction | A, B, C, D | TUM, PGW | — |
| 6BW6 | Human GPT (DPAGT1) H129 variant in complex with tunicamycin | x-ray diffraction | A, B, C, D | TUM, PGW | 20 (best 0.75) |
| 6BW6 | Human gpt (DPAGT1) H129 variant in complex with tunicamycin | x-ray diffraction | A, B, C, D | TUM, PGW | — |
| 6FM9 | Crystal structure of human UDP-N-acetylglucosamine-dolichyl-phosphate… | x-ray diffraction | A | P6L | 3 (best 0.69) |
| 6FM9 | Crystal structure of human udp-N-acetylglucosamine-dolichyl-phosphate… | x-ray diffraction | A | P6L | — |
| 6FWZ | Crystal structure of human UDP-N-acetylglucosamine-dolichyl-phosphate… | x-ray diffraction | A | MG, UD1, UNL, P6L | 3 (best 0.72) |
| 6FWZ | Crystal structure of human udp-N-acetylglucosamine-dolichyl-phosphate… | x-ray diffraction | A | MG, UD1, UNL, P6L | — |
| Q9H3H5 | AlphaFold monomer V2.0 prediction for udp-N-acetylglucosamine-- dolichyl-phosphate… | predicted | A | — | — |
Ligands
- P6L · (2S)-3-{[{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-2-[(6E)-hexadec-6-enoyloxy]propyl (8E)-octadec-8-enoate · in 6 records
- UNL · Unknown ligand · in 6 records
- PGW · (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate · in 4 records
- TUM · Tunicamycin · in 4 records
- 9LH · Tunicamycin · in 2 records
- MG · Magnesium ion · in 2 records
- UD1 · Uridine-diphosphate-N-acetylglucosamine · in 2 records
Experiment against prediction
- 6BW5 chain D against the predicted model Q9H3H5: TM-score 1.00, RMSD 0.44 Å
- 6BW5 chain D against the predicted model Q9H3H5: TM-score 1.00, RMSD 0.44 Å
- 6BW5 chain B against the predicted model Q9H3H5: TM-score 1.00, RMSD 0.47 Å
- 6BW5 chain B against the predicted model Q9H3H5: TM-score 1.00, RMSD 0.47 Å
- 6FWZ chain A against the predicted model Q9H3H5: TM-score 0.99, RMSD 0.56 Å
- 6FWZ chain A against the predicted model Q9H3H5: TM-score 0.99, RMSD 0.56 Å
- 6BW6 chain C against the predicted model Q9H3H5: TM-score 0.99, RMSD 0.56 Å
- 6BW6 chain C against the predicted model Q9H3H5: TM-score 0.99, RMSD 0.56 Å
- 6BW5 chain C against the predicted model Q9H3H5: TM-score 0.99, RMSD 0.65 Å
- 6BW5 chain C against the predicted model Q9H3H5: TM-score 0.99, RMSD 0.65 Å
Elsewhere
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