UniProt Q9GZZ1
N-alpha-acetyltransferase 50 (Q9GZZ1)
N-alpha-acetyltransferase 50 (UniProt Q9GZZ1), EC 2.3.1.-, 2.3.1.258: 27 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 38 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9GZZ1
- Protein
- N-alpha-acetyltransferase 50
- EC
- 2.3.1.-, 2.3.1.258, 2.5.1.18
- Experimental structures
- 27
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 38 · 9 records with a druggable one
Structures
28 records of Q9GZZ1 in the MolNFT archive: 27 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2OB0 | Human MAK3 homolog in complex with Acetyl-CoA | x-ray diffraction | A, B, C | — | — |
| 2OB0 | Human MAK3 homolog in complex with acetyl-CoA | x-ray diffraction | A, B, C | — | — |
| 2PSW | Human MAK3 homolog in complex with CoA | x-ray diffraction | A, B, C | — | — |
| 2PSW | Human MAK3 homolog in complex with CoA | x-ray diffraction | A, B, C | — | — |
| 3TFY | Naa50p amino-terminal acetyltransferase bound to substrate peptide fragment and CoA | x-ray diffraction | A, B, C | — | — |
| 3TFY | NAA50P amino-terminal acetyltransferase bound to substrate peptide fragment and CoA | x-ray diffraction | A, B, C | — | — |
| 4X5K | Human NAA50 complex with coenzyme A and an acetylated peptide | x-ray diffraction | A | — | — |
| 4X5K | Human NAA50 complex with coenzyme a and an acetylated peptide | x-ray diffraction | A | — | — |
| 6PPL | Cryo-EM structure of human NatE complex (NatA/Naa50) | electron microscopy | A | ACO | 3 (best 0.84) |
| 6PPL | Cryo-EM structure of human nate complex (NATA/NAA50) | electron microscopy | A | ACO | — |
| 6PW9 | Cryo-EM structure of human NatE/HYPK complex | electron microscopy | A | ACO | 3 (best 0.85) |
| 6PW9 | Cryo-EM structure of human NATE/HYPK complex | electron microscopy | A | ACO | — |
| 6WF3 | Crystal structure of human Naa50 in complex with a cofactor derived inhibitor (compound 1) | x-ray diffraction | A, B, C, D, E, F | COA | 11 (best 0.71) |
| 6WF3 | Crystal structure of human NAA50 in complex with a cofactor derived inhibitor (compound 1) | x-ray diffraction | A, B, C, D, E, F | ACE, COA | — |
| 6WF5 | Crystal structure of human Naa50 in complex with a truncated cofactor derived inhibitor (compound 2) | x-ray diffraction | A, B | U44 | 3 (best 0.61) |
| 6WF5 | Crystal structure of human NAA50 in complex with a truncated cofactor derived inhibitor (compound 2) | x-ray diffraction | A, B | ACE, NH2, U44 | — |
| 6WFG | Crystal structure of human Naa50 in complex with an inhibitor (compound 3) identified using DNA… | x-ray diffraction | A, C, E | COA, U3V | 5 (best 0.68) |
| 6WFG | Crystal structure of human NAA50 in complex with an inhibitor (compound 3) identified using DNA… | x-ray diffraction | A, C, E | COA, U3V | — |
| 6WFK | Crystal structure of human Naa50 in complex with CoA and an inhibitor (compound 4a) identified… | x-ray diffraction | A, B, C | COA, U2J | 6 (best 0.67) |
| 6WFK | Crystal structure of human NAA50 in complex with CoA and an inhibitor (compound 4A) identified… | x-ray diffraction | A, B, C | COA, U2J | — |
| 6WFN | Crystal structure of human Naa50 in complex with AcCoA and an inhibitor (compound 4a) identified… | x-ray diffraction | A | ACO, U2J | 1 (best 0.63) |
| 6WFN | Crystal structure of human NAA50 in complex with accoa and an inhibitor (compound 4A) identified… | x-ray diffraction | A | ACO, U2J | — |
| 6WFO | Crystal structure of human Naa50 in complex with AcCoA and an inhibitor (compound 4b) identified… | x-ray diffraction | A, B, C | ACO, U3Y | 5 (best 0.68) |
| 6WFO | Crystal structure of human NAA50 in complex with accoa and an inhibitor (compound 4B) identified… | x-ray diffraction | A, B, C | ACO, U3Y | — |
| 9F1B | Mammalian ternary complex of a translating 80S ribosome, NAC and NatA/E | electron microscopy | DA | — | — |
| 9F1C | Mammalian quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatA/E | electron microscopy | DA | — | — |
| 9F1D | Mammalian quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatA/E-HYPK | electron microscopy | DA | — | — |
| Q9GZZ1 | AlphaFold monomer V2.0 prediction for N-alpha-acetyltransferase 50 (Q9GZZ1) | predicted | A | — | 1 (best 0.67) |
Ligands
- ACO · Acetyl coenzyme *A · in 8 records
- COA · Coenzyme A · in 6 records
- U2J · (4S)-1-methyl-N-{(3S,5S)-5-[4-(methylcarbamoyl)-1,3-thiazol-2-yl]-1-[4-(1H-tetrazol-5-yl)benzene-1-carbonyl]pyrrolidin-3-yl}-2,6-dioxohexahydropyrimidine-4-carboxamide · in 4 records
- ACE · Acetyl group · in 2 records
- U3V · (2S)-N-[(2S)-3-[1-(3-tert-butyl-1-methyl-1H-pyrazole-5-carbonyl)piperidin-4-yl]-1-(methylamino)-1-oxopropan-2-yl]-6-oxopiperidine-2-carboxamide · in 2 records
- U3Y · (4S)-1-methyl-N-{(3S,5R)-5-[4-(methylcarbamoyl)-1,3-thiazol-2-yl]-1-[4-(1H-tetrazol-5-yl)benzene-1-carbonyl]pyrrolidin-3-yl}-2,6-dioxohexahydropyrimidine-4-carboxamide · in 2 records
- U44 · (2R)-2-hydroxy-3,3-dimethyl-N-{3-oxo-3-[(2-sulfanylethyl)amino]propyl}butanamide · in 2 records
- NH2 · Amino group · in 1 record
Experiment against prediction
- 6WFK chain C against the predicted model Q9GZZ1: TM-score 1.00, RMSD 0.32 Å
- 6WFK chain C against the predicted model Q9GZZ1: TM-score 1.00, RMSD 0.32 Å
- 6WFG chain A against the predicted model Q9GZZ1: TM-score 0.99, RMSD 0.34 Å
- 6WFG chain A against the predicted model Q9GZZ1: TM-score 0.99, RMSD 0.34 Å
- 6WFO chain C against the predicted model Q9GZZ1: TM-score 0.99, RMSD 0.35 Å
- 6WFO chain C against the predicted model Q9GZZ1: TM-score 0.99, RMSD 0.35 Å
- 6WFG chain E against the predicted model Q9GZZ1: TM-score 0.99, RMSD 0.35 Å
- 6WFG chain E against the predicted model Q9GZZ1: TM-score 0.99, RMSD 0.35 Å
- 6WF3 chain A against the predicted model Q9GZZ1: TM-score 0.99, RMSD 0.37 Å
- 6WF3 chain A against the predicted model Q9GZZ1: TM-score 0.99, RMSD 0.37 Å
Elsewhere
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