UniProt Q9GZC8
Systemic RNA interference defective protein 1 (Q9GZC8)
Systemic RNA interference defective protein 1 (UniProt Q9GZC8): 4 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 91 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9GZC8
- Protein
- Systemic RNA interference defective protein 1
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 91 · 5 records with a druggable one
Structures
5 records of Q9GZC8 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8HIP | dsRNA transporter | electron microscopy | B, A | NAG, 6OU, ZN | 17 (best 0.85) |
| 8HKE | dsRNA transporter | electron microscopy | B, A | ZN | 19 (best 0.85) |
| 8XBS | C. elegans apo-SID1 structure | electron microscopy | A, B | NAG, ZN, CLR, POV | 20 (best 0.85) |
| 8XC1 | C. elegans SID1 in complex with dsRNA | electron microscopy | A, B | NAG, ZN, CLR, POV | 20 (best 0.80) |
| Q9GZC8 | AlphaFold monomer V2.0 prediction for systemic RNA interference defective protein 1 (Q9GZC8) | predicted | A | — | 15 (best 0.81) |
Ligands
- ZN · Zinc ion · in 4 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 3 records
- CLR · Cholesterol · in 2 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 2 records
- 6OU · [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate · in 1 record
Experiment against prediction
- 8HKE chain B against the predicted model Q9GZC8: TM-score 0.92, RMSD 2.74 Å
- 8XBS chain A against the predicted model Q9GZC8: TM-score 0.91, RMSD 2.84 Å
- 8HIP chain B against the predicted model Q9GZC8: TM-score 0.91, RMSD 2.91 Å
- 8XC1 chain A against the predicted model Q9GZC8: TM-score 0.91, RMSD 2.99 Å
- 8HKE chain A against the predicted model Q9GZC8: TM-score 0.91, RMSD 3.05 Å
Elsewhere
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