UniProt Q99523
Sortilin (Q99523)
Sortilin (UniProt Q99523): 26 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 48 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q99523
- Protein
- Sortilin
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 48 · 9 records with a druggable one
Structures
27 records of Q99523 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3F6K | Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with neurotensin | x-ray diffraction | A | — | — |
| 3F6K | Crystal structure of the VPS10P domain of human SORTILIN/NTS3 in complex with neurotensin | x-ray diffraction | A | — | — |
| 3G2U | VHS Domain of human GGA1 complexed with Sotilin C-terminal Peptide | x-ray diffraction | C, D | — | — |
| 3G2U | Vhs domain of human GGA1 complexed with sotilin C-terminal peptide | x-ray diffraction | C, D | — | — |
| 3G2V | VHS Domain of human GGA1 complexed with Sotilin C-terminal Phosphopeptide | x-ray diffraction | C, D | — | — |
| 3G2V | Vhs domain of human GGA1 complexed with sotilin C-terminal phosphopeptide | x-ray diffraction | C, D | — | — |
| 4MSL | Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with AF40431 | x-ray diffraction | A | — | — |
| 4MSL | Crystal structure of the VPS10P domain of human SORTILIN/NTS3 in complex with AF40431 | x-ray diffraction | A | — | — |
| 4N7E | Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with AF38469 | x-ray diffraction | A | — | — |
| 4N7E | Crystal structure of the VPS10P domain of human SORTILIN/NTS3 in complex with AF38469 | x-ray diffraction | A | — | — |
| 4PO7 | Structure of the Sortilin:neurotensin complex at excess neurotensin concentration | x-ray diffraction | A | — | — |
| 4PO7 | Structure of the SORTILIN:NEUROTENSIN complex at excess neurotensin concentration | x-ray diffraction | A | — | — |
| 5MRH | Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with Triazolone 1 | x-ray diffraction | A | NAG, Q9Z | 4 (best 0.66) |
| 5MRH | Crystal structure of the VPS10P domain of human SORTILIN/NTS3 in complex with triazolone 1 | x-ray diffraction | A | NAG, Q9Z | — |
| 5MRI | Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with Triazolone 18 | x-ray diffraction | A | NAG, Q9Y | 6 (best 0.60) |
| 5MRI | Crystal structure of the VPS10P domain of human SORTILIN/NTS3 in complex with triazolone 18 | x-ray diffraction | A | NAG, Q9Y | — |
| 6EHO | Dimer of the Sortilin Vps10p domain at low pH | x-ray diffraction | A | NAG, BMA, MAN | 4 (best 0.57) |
| 6EHO | Dimer of the sortilin VPS10P domain at low pH | x-ray diffraction | A | NAG, BMA | — |
| 6X3L | Sortilin-Progranulin Interaction With Compound 2 | x-ray diffraction | A | NAG, UMJ | 4 (best 0.63) |
| 6X3L | Sortilin-progranulin interaction with compound 2 | x-ray diffraction | A | NAG, UMJ | — |
| 6X48 | Sortilin-Progranulin Interaction With Compound 17 | x-ray diffraction | A | NAG, UP4, UNL | 4 (best 0.65) |
| 6X48 | Sortilin-progranulin interaction with compound 17 | x-ray diffraction | A | NAG, UP4, UNL | — |
| 6X4H | Sortilin-Progranulin Interaction With Compound 24 | x-ray diffraction | A | NAG, UOY | 5 (best 0.62) |
| 6X4H | Sortilin-progranulin interaction with compound 24 | x-ray diffraction | A | NAG, UOY | — |
| 8T8R | Sortilin-PGRN peptide complex | x-ray diffraction | A | NAG | 5 (best 0.63) |
| 8T8S | Sortilin-PGRN peptide complex | x-ray diffraction | A, B | NAG, CL | 10 (best 0.72) |
| Q99523 | AlphaFold monomer V2.0 prediction for sortilin (Q99523) | predicted | A | — | 6 (best 0.77) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 14 records
- BMA · beta-D-mannopyranose · in 2 records
- Q9Y · ~{N}-methyl-3-(3-methylbutyl)-5-oxidanyl-1,2,3-triazole-4-carboxamide · in 2 records
- Q9Z · 3-(3-methylbutyl)-4~{H}-1,2,3-triazol-5-one · in 2 records
- UMJ · 1-benzyl-3-tert-butyl-1H-pyrazole-5-carboxylic acid · in 2 records
- UNL · Unknown ligand · in 2 records
- UOY · 4-methyl-N-(6-phenoxypyridine-3-carbonyl)-L-leucine · in 2 records
- UP4 · N-(3,5-dichlorobenzene-1-carbonyl)-5,5-dimethyl-L-norleucine · in 2 records
- CL · Chloride ion · in 1 record
- MAN · alpha-D-mannopyranose · in 1 record
Experiment against prediction
- 6X4H chain A against the predicted model Q99523: TM-score 1.00, RMSD 0.54 Å
- 6X4H chain A against the predicted model Q99523: TM-score 1.00, RMSD 0.54 Å
- 4MSL chain A against the predicted model Q99523: TM-score 1.00, RMSD 0.54 Å
- 4MSL chain A against the predicted model Q99523: TM-score 1.00, RMSD 0.54 Å
- 6X3L chain A against the predicted model Q99523: TM-score 1.00, RMSD 0.64 Å
- 6X3L chain A against the predicted model Q99523: TM-score 1.00, RMSD 0.64 Å
- 6X48 chain A against the predicted model Q99523: TM-score 0.99, RMSD 0.65 Å
- 6X48 chain A against the predicted model Q99523: TM-score 0.99, RMSD 0.65 Å
- 4N7E chain A against the predicted model Q99523: TM-score 0.99, RMSD 0.70 Å
- 4N7E chain A against the predicted model Q99523: TM-score 0.99, RMSD 0.70 Å
Elsewhere
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