UniProt Q99321
Diphosphoinositol polyphosphate phosphohydrolase DDP1 (Q99321)
Diphosphoinositol polyphosphate phosphohydrolase DDP1 (UniProt Q99321), EC 3.6.1.52, 3.6.1.60: 26 experimental structures and 1 predicted model on GenesisL1, 14 ligands bound, 12 pockets. Binding sites, druggability and…
- UniProt
- Q99321
- Protein
- Diphosphoinositol polyphosphate phosphohydrolase DDP1
- EC
- 3.6.1.52, 3.6.1.60
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 14
- Pockets
- 12 · 0 records with a druggable one
Structures
27 records of Q99321 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7AUI | Yeast Diphosphoinositol Polyphosphate Phosphohydrolase DDP1 in complex with InsP6 | x-ray diffraction | A | IHP | 1 (best 0.36) |
| 7AUI | Yeast diphosphoinositol polyphosphate phosphohydrolase DDP1 in complex with INSP6 | x-ray diffraction | A | IHP | — |
| 7AUJ | Yeast Diphosphoinositol Polyphosphate Phosphohydrolase DDP1 mutation E80Q in complex with 1-InsP7 | x-ray diffraction | A | O81, MG | 1 (best 0.39) |
| 7AUJ | Yeast diphosphoinositol polyphosphate phosphohydrolase DDP1 mutation E80Q in complex with 1-INSP7 | x-ray diffraction | A | O81, MG | — |
| 7AUK | Yeast Diphosphoinositol Polyphosphate Phosphohydrolase DDP1 in complex with 5-InsP7 | x-ray diffraction | A | I7P | 1 (best 0.38) |
| 7AUK | Yeast diphosphoinositol polyphosphate phosphohydrolase DDP1 in complex with 5-INSP7 | x-ray diffraction | A | I7P | — |
| 7AUL | Yeast Diphosphoinositol Polyphosphate Phosphohydrolase DDP1 in complex with 5-InsP7 in presence of… | x-ray diffraction | A | I7P, MG | 1 (best 0.40) |
| 7AUL | Yeast diphosphoinositol polyphosphate phosphohydrolase DDP1 in complex with 5-INSP7 in presence of… | x-ray diffraction | A | I7P, MG | — |
| 7AUM | Yeast Diphosphoinositol Polyphosphate Phosphohydrolase DDP1 in complex with 5-PCF2Am-InsP5 | x-ray diffraction | A | KDJ | 1 (best 0.38) |
| 7AUM | Yeast diphosphoinositol polyphosphate phosphohydrolase DDP1 in complex with 5-PCF2AM-INSP5 | x-ray diffraction | A | KDJ | — |
| 7AUN | Yeast Diphosphoinositol Polyphosphate Phosphohydrolase DDP1 in complex with PCP-InsP8 | x-ray diffraction | A | 4WZ, MG | 1 (best 0.34) |
| 7AUN | Yeast diphosphoinositol polyphosphate phosphohydrolase DDP1 in complex with pcp-INSP8 | x-ray diffraction | A | 4WZ, MG | — |
| 7AUO | Yeast Diphosphoinositol Polyphosphate Phosphohydrolase DDP1 in complex with PA-InsP8 | x-ray diffraction | A | 4WY | 1 (best 0.40) |
| 7AUO | Yeast diphosphoinositol polyphosphate phosphohydrolase DDP1 in complex with pa-INSP8 | x-ray diffraction | A | 4WY | — |
| 7AUP | Yeast Diphosphoinositol Polyphosphate Phosphohydrolase DDP1 in complex with PCP-InsP7 | x-ray diffraction | A | VEB, MG | 1 (best 0.39) |
| 7AUP | Yeast diphosphoinositol polyphosphate phosphohydrolase DDP1 in complex with pcp-INSP7 | x-ray diffraction | A | VEB, MG | — |
| 7AUQ | Yeast Diphosphoinositol Polyphosphate Phosphohydrolase DDP1 in complex with Ap5A and Ca2+ | x-ray diffraction | A | 5FA, ADE, CA | 1 (best 0.34) |
| 7AUQ | Yeast diphosphoinositol polyphosphate phosphohydrolase DDP1 in complex with AP5A and CA2+ | x-ray diffraction | A | 5FA, ADE, CA | — |
| 7AUR | Yeast Diphosphoinositol Polyphosphate Phosphohydrolase DDP1 in complex with AMP-PNP | x-ray diffraction | A | ANP, MG, CL | 1 (best 0.29) |
| 7AUR | Yeast diphosphoinositol polyphosphate phosphohydrolase DDP1 in complex with AMP-pnp | x-ray diffraction | A | ANP, MG, CL | — |
| 7AUS | Yeast Diphosphoinositol Polyphosphate Phosphohydrolase DDP1 in complex with P15 | x-ray diffraction | A | RYT, MG | 1 (best 0.43) |
| 7AUS | Yeast diphosphoinositol polyphosphate phosphohydrolase DDP1 in complex with P15 | x-ray diffraction | A | RYT, MG | — |
| 7AUT | Yeast Diphosphoinositol Polyphosphate Phosphohydrolase DDP1 mutation K63A | x-ray diffraction | A | MG, CL | 1 (best 0.43) |
| 7AUT | Yeast diphosphoinositol polyphosphate phosphohydrolase DDP1 mutation K63A | x-ray diffraction | A | MG | — |
| 7AUU | Yeast Diphosphoinositol Polyphosphate Phosphohydrolase DDP1-nose mutant in complex with InsP6 | x-ray diffraction | A | IHP, MG | — |
| 7AUU | Yeast diphosphoinositol polyphosphate phosphohydrolase DDP1-nose mutant in complex with INSP6 | x-ray diffraction | A | IHP, MG | — |
| Q99321 | AlphaFold monomer V2.0 prediction for diphosphoinositol polyphosphate phosphohydrolase DDP1 (Q99321) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 16 records
- I7P · (1R,2R,3S,4S,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy) cyclohexyl trihydrogen diphosphate · in 4 records
- IHP · Inositol hexakisphosphate · in 4 records
- CL · Chloride ion · in 3 records
- 4WY · {[(1R,3S,4S,5R,6S)-2,4,5,6-tetrakis(phosphonooxy) cyclohexane-1,3-diyl]bis[oxy(2-oxoethane-2,1-diyl) ]}bis(phosphonic acid) · in 2 records
- 4WZ · {[(1R,3S,4S,5R,6S)-2,4,5,6-tetrakis(phosphonooxy) cyclohexane-1,3-diyl]bis[oxy(hydroxyphosphoryl) methanediyl]}bis(phosphonic acid) · in 2 records
- 5FA · Adenosine-5'-pentaphosphate · in 2 records
- ADE · Adenine · in 2 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 2 records
- CA · Calcium ion · in 2 records
- KDJ · (1,1-difluoro-2-oxo-2-{[(1S,2R,3S,4S,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl]amino}ethyl) phosphonic acid · in 2 records
- O81 · (1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentakis(phosphonooxy) cyclohexyl trihydrogen diphosphate · in 2 records
- RYT · pentadecaphosphate · in 2 records
- VEB · [oxidanyl-[(2~{S},3~{S},5~{R},6~{S})-2,3,4,5,6-pentaphosphonooxycyclohexyl]oxy-phosphoryl]methylphosphonic acid · in 2 records
Experiment against prediction
- 7AUQ chain A against the predicted model Q99321: TM-score 0.97, RMSD 1.06 Å
- 7AUQ chain A against the predicted model Q99321: TM-score 0.97, RMSD 1.06 Å
- 7AUR chain A against the predicted model Q99321: TM-score 0.97, RMSD 1.19 Å
- 7AUR chain A against the predicted model Q99321: TM-score 0.97, RMSD 1.19 Å
- 7AUU chain A against the predicted model Q99321: TM-score 0.96, RMSD 1.49 Å
- 7AUU chain A against the predicted model Q99321: TM-score 0.96, RMSD 1.49 Å
- 7AUO chain A against the predicted model Q99321: TM-score 0.95, RMSD 1.36 Å
- 7AUO chain A against the predicted model Q99321: TM-score 0.95, RMSD 1.36 Å
- 7AUI chain A against the predicted model Q99321: TM-score 0.89, RMSD 1.20 Å
- 7AUI chain A against the predicted model Q99321: TM-score 0.89, RMSD 1.20 Å
Elsewhere
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