UniProt Q96L73
Histone-lysine N-methyltransferase, H3 lysine-36 specific (Q96L73)
Histone-lysine N-methyltransferase, H3 lysine-36 specific (UniProt Q96L73), EC 2.1.1.357: 7 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 16 pockets. Binding sites, druggability and experiment…
- UniProt
- Q96L73
- Protein
- Histone-lysine N-methyltransferase, H3 lysine-36 specific
- EC
- 2.1.1.357
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 16 · 2 records with a druggable one
Structures
8 records of Q96L73 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3OOI | Crystal Structure of Human Histone-Lysine N-methyltransferase NSD1 SET domain in Complex with… | x-ray diffraction | A | — | — |
| 3OOI | Crystal structure of human histone-lysine N-methyltransferase NSD1 set domain in complex with… | x-ray diffraction | A | — | — |
| 6KQP | NSD1 SET domain in complex with SAM | x-ray diffraction | A | ZN | — |
| 6KQP | NSD1 set domain in complex with SAM | x-ray diffraction | A | ZN | — |
| 6KQQ | NSD1 SET domain in complex with BT3 and SAM | x-ray diffraction | A, B | DQL, DW9, ZN, CA | — |
| 6KQQ | NSD1 set domain in complex with BT3 and SAM | x-ray diffraction | A, B | DQL, DW9, ZN, CA | — |
| 8C5L | NR2F6 ligand binding domain in complex with NSD1 peptide | x-ray diffraction | C, D | — | 1 (best 0.56) |
| Q96L73 | AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase, H3 lysine-36 specific… | predicted | A | — | 15 (best 0.74) |
Ligands
Experiment against prediction
- 6KQP chain A against the predicted model Q96L73: TM-score 0.95, RMSD 1.53 Å
- 6KQP chain A against the predicted model Q96L73: TM-score 0.95, RMSD 1.53 Å
- 6KQQ chain B against the predicted model Q96L73: TM-score 0.94, RMSD 1.46 Å
- 6KQQ chain B against the predicted model Q96L73: TM-score 0.94, RMSD 1.46 Å
- 6KQQ chain A against the predicted model Q96L73: TM-score 0.92, RMSD 1.80 Å
- 6KQQ chain A against the predicted model Q96L73: TM-score 0.92, RMSD 1.80 Å
- 3OOI chain A against the predicted model Q96L73: TM-score 0.92, RMSD 2.30 Å
- 3OOI chain A against the predicted model Q96L73: TM-score 0.92, RMSD 2.30 Å
- 8C5L chain C against the predicted model Q96L73: TM-score 0.77, RMSD 1.29 Å
- 8C5L chain D against the predicted model Q96L73: TM-score 0.75, RMSD 1.29 Å
Elsewhere
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