MolNFT v1 · #270470 · protein
AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase, H3 lysine-36 specific (Q96L73)
Q96L73: “AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase, H3 lysine-36 specific (Q96L73)”. 15 pockets (best druggability 0.74). MolNFT v1 #270470 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q96L73
- Type
- protein
- Length
- 2,696 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x3298b100681D3A2372Bba3b2f282750dD71629B9
- Molecule
- Histone-lysine N-methyltransferase, H3 lysine-36 specific
- UniProt
- Q96L73
- Pockets
- 15 · best druggability 0.74
Structure
1 distinct chain · 5% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone-lysine N-methyltransferase, H3 lysine-36 specific | protein | 2696 | 5% helix, 6% strand | Q96L73 |
Pockets
15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 974 | 0.74 | 0.77 | 71 | empty |
| 2 | 1015 | 0.73 | 0.76 | 67 | empty |
| 3 | 400 | 0.70 | 0.82 | 46 | empty |
| 4 | 97 | 0.60 | 0.87 | 22 | empty |
| 5 | 65 | 0.58 | 0.89 | 12 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 3OOI · Crystal Structure of Human Histone-Lysine N-methyltransferase NSD1 SET domain in Complex… · an experimental structure of the same protein · chain A against A, TM-score 0.08
- 3OOI · Crystal structure of human histone-lysine N-methyltransferase NSD1 set domain in complex… · an experimental structure of the same protein · chain A against A, TM-score 0.08
- 6KQP · NSD1 SET domain in complex with SAM · an experimental structure of the same protein · chain A against A, TM-score 0.08
- 6KQP · NSD1 set domain in complex with SAM · an experimental structure of the same protein · chain A against A, TM-score 0.08
- 6KQQ · NSD1 set domain in complex with BT3 and SAM · an experimental structure of the same protein · chain A against A, TM-score 0.08
- 6KQQ · NSD1 SET domain in complex with BT3 and SAM · an experimental structure of the same protein · chain A against A, TM-score 0.08
- 8C5L · NR2F6 ligand binding domain in complex with NSD1 peptide · an experimental structure of the same protein · chain A against C, TM-score 0.01
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96L73
- Elsewhere: UniProt Q96L73 · AlphaFold DB Q96L73
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