UniProt Q96GG9
DCN1-like protein 1 (Q96GG9)
DCN1-like protein 1 (UniProt Q96GG9), EC 3.2.1.17: 40 experimental structures and 1 predicted model on GenesisL1, 17 ligands bound, 64 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q96GG9
- Protein
- DCN1-like protein 1
- EC
- 3.2.1.17
- Experimental structures
- 40
- Predicted models
- 1
- Ligands
- 17
- Pockets
- 64 · 16 records with a druggable one
Structures
41 records of Q96GG9 in the MolNFT archive: 40 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3TDU | N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex… | x-ray diffraction | A, B | — | — |
| 3TDU | N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex… | x-ray diffraction | A, B | — | — |
| 3TDZ | N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex… | x-ray diffraction | A, B | — | — |
| 3TDZ | N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex… | x-ray diffraction | A, B | — | — |
| 4P5O | Structure of an RBX1-UBC12~NEDD8-CUL1-DCN1 complex: a RING-E3-E2~ubiquitin-like protein-substrate… | x-ray diffraction | E, F | — | — |
| 4P5O | Structure of an RBX1-UBC12~NEDD8-CUL1-DCN1 complex: a ring-E3- E2~UBIQUITIN-like protein-substrate… | x-ray diffraction | E, F | — | — |
| 5UFI | DCN1 bound to DI-591 | x-ray diffraction | A, B, C, D | 8B1 | 5 (best 0.85) |
| 5UFI | DCN1 bound to di-591 | x-ray diffraction | A, B, C, D | 8B1 | — |
| 5V83 | Structure of DCN1 bound to NAcM-HIT | x-ray diffraction | A | 8Z7 | — |
| 5V83 | Structure of DCN1 bound to nacm-hit | x-ray diffraction | A | 8Z7 | — |
| 5V86 | Structure of DCN1 bound to NAcM-OPT | x-ray diffraction | A | 8ZA | 3 (best 0.65) |
| 5V86 | Structure of DCN1 bound to nacm-opt | x-ray diffraction | A | 8ZA | — |
| 5V88 | Structure of DCN1 bound to NAcM-COV | x-ray diffraction | A | 8ZD | 4 (best 0.60) |
| 5V88 | Structure of DCN1 bound to nacm-cov | x-ray diffraction | A | 8ZD | — |
| 6B5Q | DCN1 bound to 38 | x-ray diffraction | A, B | — | 3 (best 0.81) |
| 6B5Q | DCN1 bound to 38 | x-ray diffraction | A, B | CZS, 2KY, 1XY | — |
| 6BG3 | Structure of (3S,4S)-1-benzyl-4-(3-(3-(trifluoromethyl)phenyl)ureido)piperidin-3-yl acetate bound… | x-ray diffraction | A | DOJ | 3 (best 0.63) |
| 6BG3 | Structure of (3S,4S)-1-benzyl-4-(3-(3-(TRIFLUOROMETHYL)PHENYL)UREIDO) piperidin-3-yl acetate bound… | x-ray diffraction | A | DOJ | — |
| 6BG5 | Structure of 1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-(1-propylpiperidin-4-yl)-3-(3-(trifluoromethyl)phe… | x-ray diffraction | A | DQD | — |
| 6BG5 | Structure of 1-(BENZO[D][1,3]DIOXOL-5-ylmethyl)-1-(1-propylpiperidin… | x-ray diffraction | A | DQD | — |
| 6P5V | Structure of DCN1 bound to N-((4S,5S)-7-ethyl-4-(4-fluorophenyl)-3-methyl-6-oxo-1-phenyl-4,5,6,7-tet… | x-ray diffraction | A | O37 | 5 (best 0.58) |
| 6P5V | Structure of DCN1 bound to N-((4S,5S)-7-ethyl-4-(4-fluorophenyl)-3… | x-ray diffraction | A | — | — |
| 6P5W | Structure of DCN1 bound to 3-methyl-N-((4S,5S)-3-methyl-6-oxo-1-phenyl-4-(p-tolyl)-4,5,6,7-tetrahydr… | x-ray diffraction | A | O0A | 4 (best 0.59) |
| 6P5W | Structure of DCN1 bound to 3-methyl-N-((4S,5S)-3-methyl-6-oxo-1… | x-ray diffraction | A | O0A | — |
| 6XOL | DCN1 bound to DI-1548 | x-ray diffraction | A | H8S | 4 (best 0.68) |
| 6XOL | DCN1 bound to di-1548 | x-ray diffraction | A | H8S | — |
| 6XOM | DCN1 bound to 8 | x-ray diffraction | A | H8V | 5 (best 0.67) |
| 6XOM | DCN1 bound to 8 | x-ray diffraction | A | H8V | — |
| 6XON | DCN1 bound to inhibitor 9 | x-ray diffraction | A | H9M | 4 (best 0.69) |
| 6XON | DCN1 bound to inhibitor 9 | x-ray diffraction | A | H9M | — |
| 6XOO | DCN1 bound to DI-1859 | x-ray diffraction | A | H8S | 4 (best 0.68) |
| 6XOO | DCN1 bound to di-1859 | x-ray diffraction | A | H8S | — |
| 6XOP | DCN1 bound to inhibitor 10 | x-ray diffraction | A | H9P | 5 (best 0.70) |
| 6XOP | DCN1 bound to inhibitor 10 | x-ray diffraction | A | H9P | — |
| 6XOQ | DCN1 covalently bound to inhibitor 4 | x-ray diffraction | A | H9S | 5 (best 0.70) |
| 6XOQ | DCN1 covalently bound to inhibitor 4 | x-ray diffraction | A | H9S | — |
| 7KWA | Structure of DCN1 bound to N-((4S,5S)-3-(aminomethyl)-7-ethyl-4-(4-fluorophenyl)-6-oxo-1-phenyl-4,5… | x-ray diffraction | A | YHP | 4 (best 0.61) |
| 7KWA | Structure of DCN1 bound to N-((4S,5S)-3-(aminomethyl)-7-ethyl-4-(4… | x-ray diffraction | A | YHP | — |
| 8OR2 | CAND1-CUL1-RBX1-DCNL1 | electron microscopy | F | — | 3 (best 0.87) |
| 8OR3 | CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1 | electron microscopy | F | — | 3 (best 0.68) |
| Q96GG9 | AlphaFold monomer V2.0 prediction for DCN1-like protein 1 (Q96GG9) | predicted | A | — | — |
Ligands
- H8S · N-{(1S)-1-cyclohexyl-2-[(2-methylpropanoyl) amino]ethyl}-N~2~-propanoyl-3-[6-(propan-2-yl)-1,3-benzothiazol-2-yl]-L-alaninamide · in 4 records
- 8B1 · N-[(1S)-1-cyclohexyl-2-{[3-(morpholin-4-yl) propanoyl]amino}ethyl]-N~2~-propanoyl-3-[6-(propan-2-yl)-1,3-benzothiazol-2-yl]-L-alaninamide · in 2 records
- 8Z7 · N-(1-benzylpiperidin-4-yl)-N'-[3-(trifluoromethyl) phenyl]urea · in 2 records
- 8ZA · N-benzyl-N-(1-butylpiperidin-4-yl)-N'-(3,4-dichlorophenyl)urea · in 2 records
- 8ZD · N-{2-[({1-[(2R)-pentan-2-yl]piperidin-4-yl}{[3-(trifluoromethyl)phenyl]carbamoyl}amino) methyl]phenyl}propanamide · in 2 records
- DOJ · N-{(3S,4S)-1-benzyl-3-[(1S)-1-hydroxyethoxy]piperidin-4-yl}-N'-[3-(trifluoromethyl)phenyl]urea · in 2 records
- DQD · N-[(2H-1,3-benzodioxol-5-yl)methyl]-N-(1-propylpiperidin-4-yl)-N'-[3-(trifluoromethyl) phenyl]urea · in 2 records
- H8V · (2R)-N-[(2S)-2-cyclohexyl-2-({N-propanoyl-3-[6-(propan-2-yl)-1,3-benzothiazol-2-yl]-L-alanyl}amino)ethyl]-2-methyl-4-(morpholin-4-yl)butanamide · in 2 records
- H9M · (2S)-N-[(2S)-2-cyclohexyl-2-({N-propanoyl-3-[6-(propan-2-yl)-1,3-benzothiazol-2-yl]-L-alanyl}amino)ethyl]-4-(dimethylamino)-2-methylbutanamide · in 2 records
- H9P · N-[(1S)-1-cyclohexyl-2-{[(2S)-3-(1H-imidazol-1-yl)-2-methylpropanoyl]amino}ethyl]-N~2~-propanoyl-3-[6-(propan-2-yl)-1,3-benzothiazol-2-yl]-L-alaninamide · in 2 records
- H9S · (2E)-N-[(2S)-2-cyclohexyl-2-({N-propanoyl-3-[6-(propan-2-yl)-1,3-benzothiazol-2-yl]-L-alanyl}amino)ethyl]-4-(morpholin-4-yl)but-2-enamide · in 2 records
- O0A · 3-methyl-N-[(4S,5S)-3-methyl-4-(4-methylphenyl)-6-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl]benzamide · in 2 records
- YHP · N-[(4S,5S)-3-(aminomethyl)-7-ethyl-4-(4-fluorophenyl)-6-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl]-3-(trifluoromethyl)benzamide · in 2 records
- 1XY · (4R)-3,4-dihydro-2H-chromen-4-amine · in 1 record
- 2KY · (2S)-amino(cyclopentyl)ethanoic acid · in 1 record
- CZS · 3-(6-chloro-1,3-benzothiazol-2-yl)-L-alanine · in 1 record
- O37 · N-[(4S,5S)-1-[(1S)-cyclohex-3-en-1-yl]-7-ethyl-4-(4-fluorophenyl)-3-methyl-6-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl]-3-methylbenzamide · in 1 record
Experiment against prediction
- 3TDZ chain A against the predicted model Q96GG9: TM-score 0.98, RMSD 0.69 Å
- 3TDZ chain A against the predicted model Q96GG9: TM-score 0.98, RMSD 0.69 Å
- 5UFI chain C against the predicted model Q96GG9: TM-score 0.98, RMSD 0.72 Å
- 5UFI chain C against the predicted model Q96GG9: TM-score 0.98, RMSD 0.72 Å
- 3TDZ chain B against the predicted model Q96GG9: TM-score 0.98, RMSD 0.74 Å
- 3TDZ chain B against the predicted model Q96GG9: TM-score 0.98, RMSD 0.74 Å
- 5UFI chain D against the predicted model Q96GG9: TM-score 0.98, RMSD 0.78 Å
- 5UFI chain D against the predicted model Q96GG9: TM-score 0.98, RMSD 0.78 Å
- 3TDU chain A against the predicted model Q96GG9: TM-score 0.98, RMSD 0.82 Å
- 3TDU chain A against the predicted model Q96GG9: TM-score 0.98, RMSD 0.82 Å
Elsewhere
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