UniProt Q92630
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (Q92630)
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (UniProt Q92630), EC 2.7.12.1: 32 experimental structures and 1 predicted model on GenesisL1, 22 ligands bound, 11 pockets. Binding sites, druggability and experiment…
- UniProt
- Q92630
- Protein
- Dual specificity tyrosine-phosphorylation-regulated kinase 2
- EC
- 2.7.12.1
- Experimental structures
- 32
- Predicted models
- 1
- Ligands
- 22
- Pockets
- 11 · 2 records with a druggable one
Structures
33 records of Q92630 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3K2L | Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) | x-ray diffraction | A | — | — |
| 3K2L | Crystal structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) | x-ray diffraction | A | — | — |
| 3KVW | Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) in… | x-ray diffraction | A | — | — |
| 3KVW | Crystal structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) in… | x-ray diffraction | A | — | — |
| 4AZF | Human DYRK2 in complex with Leucettine L41 | x-ray diffraction | A | — | — |
| 4AZF | Human DYRK2 in complex with leucettine L41 | x-ray diffraction | A | — | — |
| 5LXC | Crystal structure of DYRK2 in complex with EHT 5372 (Compound 1) | x-ray diffraction | A, B | 7AA | — |
| 5LXC | Crystal structure of DYRK2 in complex with eht 5372 (compound 1) | x-ray diffraction | A, B | 7AA | — |
| 5LXD | Crystal structure of DYRK2 in complex with EHT 1610 (compound 2) | x-ray diffraction | A, B | 7A7 | — |
| 5LXD | Crystal structure of DYRK2 in complex with eht 1610 (compound 2) | x-ray diffraction | A, B | 7A7 | — |
| 5ZTN | The crystal structure of human DYRK2 in complex with Curcumin | x-ray diffraction | A, B | CUR | 9 (best 0.76) |
| 5ZTN | The crystal structure of human DYRK2 in complex with curcumin | x-ray diffraction | A, B | CUR | — |
| 6HDP | Human DYRK2 bound to Scorzodihydrostilbene A | x-ray diffraction | A | FZ5 | — |
| 6HDP | Human DYRK2 bound to scorzodihydrostilbene a | x-ray diffraction | A | FZ5 | — |
| 6HDR | Human DYRK2 bound to Curcumin | x-ray diffraction | A | CC9, PO4 | — |
| 6HDR | Human DYRK2 bound to curcumin | x-ray diffraction | A | CC9, PO4 | — |
| 6K0J | The co-crystal structure of DYRK2 with a small molecule inhibitor | x-ray diffraction | A | CQO | — |
| 7AKF | Structure of DYRK2 in complex with compound 50 | x-ray diffraction | A | RK5, CL | — |
| 7AKH | Structure of DYRK2 in complex with compound 58 | x-ray diffraction | A | RK8, CL | — |
| 7DG4 | The co-crystal structure of DYRK2 with a small molecule inhibitor 6 | x-ray diffraction | A | H5R | — |
| 7DH3 | The co-crystal structure of DYRK2 with a small molecule inhibitor 5 | x-ray diffraction | A | H7C | — |
| 7DH9 | The co-crystal structure of DYRK2 with a small molecule inhibitor 7 | x-ray diffraction | A | H7F | — |
| 7DHC | The co-crystal structure of DYRK2 with a small molecule inhibitor 10 | x-ray diffraction | A | H99 | — |
| 7DHH | The co-crystal structure of DYRK2 with a small molecule inhibitor 19 | x-ray diffraction | A | H7L | — |
| 7DHK | The co-crystal structure of DYRK2 with a small molecule inhibitor 13 | x-ray diffraction | A | H7O | — |
| 7DHN | The co-crystal structure of DYRK2 with a small molecule inhibitor 20 | x-ray diffraction | A | H7R | — |
| 7DHO | The co-crystal structure of DYRK2 with a small molecule inhibitor 14 | x-ray diffraction | A | H7U | — |
| 7DHV | The co-crystal structure of DYRK2 with a small molecule inhibitor 8 | x-ray diffraction | A | H7X | 2 (best 0.68) |
| 7DHV | The co-crystal structure of DYRK2 with a small molecule inhibitor 8 | x-ray diffraction | A | H7X | — |
| 7DJO | The co-crystal structure of DYRK2 with a small molecule inhibitor 17 | x-ray diffraction | A | H80 | — |
| 7DL6 | The co-crystal structure of DYRK2 with a small molecule inhibitor 18 | x-ray diffraction | A | H96 | — |
| 7EJV | The co-crystal structure of DYRK2 with yk-2-69 | x-ray diffraction | A, B | YK2 | — |
| Q92630 | AlphaFold monomer V2.0 prediction for dual specificity tyrosine- phosphorylation-regulated kinase 2… | predicted | A | — | — |
Ligands
- 7A7 · Methyl 9-[(2-fluoranyl-4-methoxy-phenyl)amino]-[1, 3]thiazolo[5,4-f]quinazoline-2-carboximidate · in 2 records
- 7AA · methyl 9-[(2,4-dichlorophenyl)amino]-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate · in 2 records
- CC9 · curcumin · in 2 records
- CL · Chloride ion · in 2 records
- CUR · (1Z,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one · in 2 records
- FZ5 · Scorzodihydrostilbene A · in 2 records
- H7X · 2,7-dimethoxy-9-(piperidin-4-ylmethylsulfanyl)acridine-4-carboxylic acid · in 2 records
- PO4 · Phosphate ion · in 2 records
- CQO · 3-(2,7-dimethoxyacridin-9-yl)sulfanylpropan-1-amine · in 1 record
- H5R · 2,7-dimethoxy-9-(piperidin-4-ylmethylsulfanyl)acridine · in 1 record
- H7C · 2,7-dimethoxy-9-piperidin-4-ylsulfanyl-acridine · in 1 record
- H7F · [2,7-dimethoxy-9-(piperidin-4-ylmethylsulfanyl)acridin-4-yl]methanol · in 1 record
- H7L · [9-(azetidin-3-ylmethylsulfanyl)-2,7-dimethoxy-acridin-4-yl]methanol · in 1 record
- H7O · 2-methoxy-7-phenylmethoxy-9-(piperidin-4-ylmethylsulfanyl)acridine · in 1 record
- H7R · 7-methoxy-2-methylsulfanyl-9-(piperidin-4-ylmethylsulfanyl)-[1,3]thiazolo[5,4-b]quinoline · in 1 record
- H7U · 2-methoxy-9-(piperidin-4-ylmethylsulfanyl)-7-propan-2-yloxy-acridine · in 1 record
- H80 · [2,7-dimethoxy-9-[[(3S)-pyrrolidin-3-yl]methylsulfanyl]acridin-4-yl]methanol · in 1 record
- H96 · [2,7-dimethoxy-9-[[(3R)-pyrrolidin-3-yl]methylsulfanyl]acridin-4-yl]methanol · in 1 record
- H99 · 4-[bis(fluoranyl)methyl]-2,7-dimethoxy-9-(piperidin-4-ylmethylsulfanyl)acridine · in 1 record
- RK5 · 4-(2,3-dimethyl-1-benzofuran-5-yl)pyridine-2,6-diamine · in 1 record
- RK8 · 4-[3-[(2~{S})-2-(6-bromanylpyridin-2-yl)oxypropyl]-2-methyl-imidazo[4,5-b]pyridin-5-yl]pyridine-2,6-diamine · in 1 record
- YK2 · [6-[[4-[2-(dimethylamino)-1,3-benzothiazol-6-yl]-5-fluoranyl-pyrimidin-2-yl]amino]pyridin-3-yl]-(4-ethylpiperazin-1-yl)methanone · in 1 record
Experiment against prediction
- 5LXD chain A against the predicted model Q92630: TM-score 0.99, RMSD 0.78 Å
- 5LXD chain A against the predicted model Q92630: TM-score 0.99, RMSD 0.78 Å
- 5LXD chain B against the predicted model Q92630: TM-score 0.99, RMSD 0.79 Å
- 5LXD chain B against the predicted model Q92630: TM-score 0.99, RMSD 0.79 Å
- 5LXC chain B against the predicted model Q92630: TM-score 0.99, RMSD 0.78 Å
- 5LXC chain B against the predicted model Q92630: TM-score 0.99, RMSD 0.78 Å
- 7DL6 chain A against the predicted model Q92630: TM-score 0.99, RMSD 0.86 Å
- 7DH3 chain A against the predicted model Q92630: TM-score 0.99, RMSD 0.87 Å
- 7DHV chain A against the predicted model Q92630: TM-score 0.99, RMSD 0.87 Å
- 7DHV chain A against the predicted model Q92630: TM-score 0.99, RMSD 0.87 Å
Elsewhere
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