Ligand · RK8
RK8 · 4-[3-[(2~{S})-2-(6-bromanylpyridin-2-yl)oxypropyl]-2-methyl-imidazo[4,5-b]pyridin-5-yl]pyridine-2,6-diamine
RK8, 4-[3-[(2~{S})-2-(6-bromanylpyridin-2-yl)oxypropyl]-2-methyl-imidazo[4,5-b]pyridin-5-yl]pyridine-2,6-diamine (C20 H20 Br N7 O, 454.3 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site…
- Component
- RK8
- Formula
- C20 H20 Br N7 O
- Class
- ligand
- Structures
- 4
- PDB entries
- 2
Binding sites
RK8 in 4 structures; the first of them:
- 7AKE · Structure of DYRK1A in complex with compound 58 · RK8 A501 · binds ILE165, GLY166, LYS167, GLY168, PHE170, VAL173, ALA186, LYS188 and 14 more
- 7AKH · Structure of DYRK2 in complex with compound 58 · RK8 A601 · binds ILE228, GLY229, LYS230, GLY231, PHE233, VAL236, ALA249, LYS251 and 12 more
- 7AKE · Structure of DYRK1A in complex with compound 58 · RK8 A501 · binds ILE165, LYS167, PHE170, ALA186, LYS188, GLU203, PHE238, GLU239 and 7 more
- 7AKH · Structure of DYRK2 in complex with compound 58 · RK8 A601 · binds ILE228, GLY229, LYS230, PHE233, VAL236, ALA249, LYS251, GLU266 and 10 more
Residues it binds most
GLU 6, PHE 6, LEU 6, LYS 6, VAL 6, ILE 6, GLY 5, ALA 6, ASP 6, SER 6 (residue and the binding sites it lines).
Found with
- CL · Chloride ion
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