UniProt Q91ZW2
GDP-fucose protein O-fucosyltransferase 1 (Q91ZW2)
GDP-fucose protein O-fucosyltransferase 1 (UniProt Q91ZW2), EC 2.4.1.221: 18 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 9 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q91ZW2
- Protein
- GDP-fucose protein O-fucosyltransferase 1
- EC
- 2.4.1.221
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 9 · 3 records with a druggable one
Structures
19 records of Q91ZW2 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5KXH | mouse POFUT1 in complex with mouse Factor VII EGF1 and GDP | x-ray diffraction | A | NAG, GDP | — |
| 5KXH | Mouse POFUT1 in complex with mouse factor VII EGF1 and GDP | x-ray diffraction | A | NAG, GDP | — |
| 5KXQ | mouse POFUT1 in complex with GDP | x-ray diffraction | A, B, C, D | NAG, GDP, NA | — |
| 5KXQ | Mouse POFUT1 in complex with GDP | x-ray diffraction | A, B, C, D | NAG, GDP, NA | — |
| 5KY0 | Mouse POFUT1 in complex with mouse NOTCH1 EGF12(D464G) and GDP | x-ray diffraction | A | NAG, GDP | — |
| 5KY2 | mouse POFUT1 in complex with O-glucosylated mouse Factor VII EGF1 and GDP | x-ray diffraction | A | NAG, GDP, BGC | — |
| 5KY2 | Mouse POFUT1 in complex with O-glucosylated mouse factor VII EGF1 and GDP | x-ray diffraction | A | NAG, GDP, BGC | — |
| 5KY3 | Mouse POFUT1 in complex with mouse factor VII EGF1 mutant (T101A) and GDP-fucose | x-ray diffraction | A | NAG, GFB | — |
| 5KY4 | mouse POFUT1 in complex with mouse Notch1 EGF26 and GDP | x-ray diffraction | A | NAG, GDP | 3 (best 0.74) |
| 5KY4 | Mouse POFUT1 in complex with mouse NOTCH1 EGF26 and GDP | x-ray diffraction | A | NAG, GDP | — |
| 5KY5 | mouse POFUT1 in complex with EGF(+) and GDP | x-ray diffraction | A | NAG, GDP | — |
| 5KY5 | Mouse POFUT1 in complex with EGF(+) and GDP | x-ray diffraction | A | NAG, GDP | — |
| 5KY7 | mouse POFUT1 in complex with O-glucosylated EGF(+) and GDP | x-ray diffraction | A | NAG, GDP, BGC | 2 (best 0.73) |
| 5KY7 | Mouse POFUT1 in complex with O-glucosylated EGF(+) and GDP | x-ray diffraction | A | NAG, GDP, BGC | — |
| 5KY8 | mouse POFUT1 in complex with O-glucosylated mouse Notch1 EGF12 mutant (D464G) and GDP | x-ray diffraction | A | NAG, GDP, BGC | — |
| 5KY8 | Mouse POFUT1 in complex with O-glucosylated mouse NOTCH1 EGF12 mutant (D464G) and GDP | x-ray diffraction | A | NAG, GDP, BGC | — |
| 5KY9 | mouse POFUT1 in complex with mouse Notch1 EGF12 mutant (D464G/A465G) and GDP | x-ray diffraction | A | NAG, GDP | — |
| 5KY9 | Mouse POFUT1 in complex with mouse NOTCH1 EGF12 mutant (D464G/A465G) and GDP | x-ray diffraction | A | NAG, GDP | — |
| Q91ZW2 | AlphaFold monomer V2.0 prediction for GDP-fucose protein O-fucosyltransferase 1 (Q91ZW2) | predicted | A | — | 4 (best 0.67) |
Ligands
Experiment against prediction
- 5KY3 chain A against the predicted model Q91ZW2: TM-score 1.00, RMSD 0.36 Å
- 5KY0 chain A against the predicted model Q91ZW2: TM-score 1.00, RMSD 0.41 Å
- 5KY9 chain A against the predicted model Q91ZW2: TM-score 1.00, RMSD 0.42 Å
- 5KY9 chain A against the predicted model Q91ZW2: TM-score 1.00, RMSD 0.42 Å
- 5KXH chain A against the predicted model Q91ZW2: TM-score 1.00, RMSD 0.44 Å
- 5KXH chain A against the predicted model Q91ZW2: TM-score 1.00, RMSD 0.44 Å
- 5KY4 chain A against the predicted model Q91ZW2: TM-score 1.00, RMSD 0.47 Å
- 5KY4 chain A against the predicted model Q91ZW2: TM-score 1.00, RMSD 0.47 Å
- 5KY5 chain A against the predicted model Q91ZW2: TM-score 1.00, RMSD 0.49 Å
- 5KY5 chain A against the predicted model Q91ZW2: TM-score 1.00, RMSD 0.49 Å
Elsewhere
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