UniProt Q8WYQ5
Microprocessor complex subunit DGCR8 (Q8WYQ5)
Microprocessor complex subunit DGCR8 (UniProt Q8WYQ5): 23 experimental structures and 1 predicted model on GenesisL1, 56 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8WYQ5
- Protein
- Microprocessor complex subunit DGCR8
- Experimental structures
- 23
- Predicted models
- 1
- Pockets
- 56 · 7 records with a druggable one
Structures
24 records of Q8WYQ5 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1X47 | Solution structure of DSRM domain in DGCR8 protein | solution nmr | A | — | — |
| 1X47 | Solution structure of dsrm domain in DGCR8 protein | solution nmr | A | — | — |
| 2YT4 | Crystal structure of human DGCR8 core | x-ray diffraction | A | — | — |
| 2YT4 | Crystal structure of human DGCR8 core | x-ray diffraction | A | — | — |
| 3LE4 | Crystal structure of the DGCR8 dimerization domain | x-ray diffraction | A | — | — |
| 3LE4 | Crystal structure of the DGCR8 dimerization domain | x-ray diffraction | A | — | — |
| 5B16 | X-ray structure of DROSHA in complex with the C-terminal tail of DGCR8. | x-ray diffraction | B, C | — | 1 (best 0.40) |
| 5B16 | X-ray structure of drosha in complex with the C-terminal tail of DGCR8. | x-ray diffraction | B, C | — | — |
| 6LXD | Pri-miRNA bound DROSHA-DGCR8 complex | electron microscopy | B, C | — | — |
| 6LXD | Pri-miRNA bound drosha-DGCR8 complex | electron microscopy | B, C | — | — |
| 6LXE | DROSHA-DGCR8 complex | electron microscopy | B, C | — | 2 (best 0.82) |
| 6LXE | Drosha-DGCR8 complex | electron microscopy | B, C | — | — |
| 6V5B | Human Drosha and DGCR8 in complex with Primary MicroRNA (MP/RNA complex) - Active state | electron microscopy | C, B | — | 8 (best 0.73) |
| 6V5B | Human drosha and DGCR8 in complex with primary microrna (MP/RNA complex) - active state | electron microscopy | C, B | — | — |
| 6V5C | Human Drosha and DGCR8 in complex with Primary MicroRNA (MP/RNA complex) - partially docked state | electron microscopy | C, B | — | 8 (best 0.84) |
| 6V5C | Human drosha and DGCR8 in complex with primary microrna (MP/RNA complex) - partially docked state | electron microscopy | C, B | — | — |
| 7CNC | cystal structure of human ERH in complex with DGCR8 | x-ray diffraction | B | — | — |
| 7CNC | Cystal structure of human erh in complex with DGCR8 | x-ray diffraction | B | — | — |
| 9ASM | Human Drosha and DGCR8 in complex with Pri-let-7f1 | electron microscopy | B, C | — | 10 (best 0.84) |
| 9ASN | Human Drosha and DGCR8 in complex with Pri-miR-98 | electron microscopy | B, C | — | 8 (best 0.81) |
| 9ASO | Human Drosha and DGCR8 in complex with Pri-let-7a2 | electron microscopy | B, C | — | 2 (best 0.44) |
| 9ASP | Human Drosha and DGCR8 in complex with Pri-let-7a1 | electron microscopy | B, C | — | 8 (best 0.83) |
| 9ASQ | Human Drosha, DGCR8 and SRSF3 in complex with Pri-let-7f1 | electron microscopy | B, C | — | 9 (best 0.83) |
| Q8WYQ5 | AlphaFold monomer V2.0 prediction for microprocessor complex subunit DGCR8 (Q8WYQ5) | predicted | A | — | — |
Experiment against prediction
- 6LXD chain B against the predicted model Q8WYQ5: TM-score 0.85, RMSD 0.68 Å
- 6LXD chain B against the predicted model Q8WYQ5: TM-score 0.85, RMSD 0.68 Å
- 2YT4 chain A against the predicted model Q8WYQ5: TM-score 0.85, RMSD 2.64 Å
- 2YT4 chain A against the predicted model Q8WYQ5: TM-score 0.85, RMSD 2.64 Å
- 5B16 chain B against the predicted model Q8WYQ5: TM-score 0.78, RMSD 0.73 Å
- 5B16 chain B against the predicted model Q8WYQ5: TM-score 0.78, RMSD 0.73 Å
- 9ASO chain B against the predicted model Q8WYQ5: TM-score 0.78, RMSD 0.71 Å
- 9ASO chain C against the predicted model Q8WYQ5: TM-score 0.77, RMSD 0.48 Å
- 1X47 chain A against the predicted model Q8WYQ5: TM-score 0.76, RMSD 2.12 Å
- 1X47 chain A against the predicted model Q8WYQ5: TM-score 0.76, RMSD 2.12 Å
Elsewhere
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