UniProt Q8WWT9
Na(+)/dicarboxylate cotransporter 3 (Q8WWT9)
Na(+)/dicarboxylate cotransporter 3 (UniProt Q8WWT9): 6 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 74 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8WWT9
- Protein
- Na(+)/dicarboxylate cotransporter 3
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 74 · 7 records with a druggable one
Structures
7 records of Q8WWT9 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8UVC | Structure of NaDC3-aKG complex | electron microscopy | A, B | NA, AKG, C14, 3PE, CLR | 10 (best 0.71) |
| 8UVD | Structure of NaDC3-PF4a complex | electron microscopy | A, B | NA, XKC, C14, 3PE, CLR | 13 (best 0.64) |
| 8UVE | Structure of NaDC3-Succinate complex in Coo-Ci conformation | electron microscopy | B, A | NA, C14, CLR, 3PE | 13 (best 0.68) |
| 8UVF | Structure of NaDC3-DMS complex in Ci-Ci conformation | electron microscopy | A, B | NA, C14, 3PE, CLR | 11 (best 0.70) |
| 8UVG | Structure of NaDC3-DMS complex in Co-Ci conformation | electron microscopy | B, A | XKH, C14, CLR, NA, 3PE | 12 (best 0.72) |
| 8UVI | Structure of NaDC3-Succinate complex in Coo-Coo conformation | electron microscopy | A, B | NA, C14, CLR | 10 (best 0.68) |
| Q8WWT9 | AlphaFold monomer V2.0 prediction for solute carrier family 13 member 3 (Q8WWT9) | predicted | A | — | 5 (best 0.65) |
Ligands
- C14 · Tetradecane · in 6 records
- CLR · Cholesterol · in 6 records
- NA · Sodium ion · in 6 records
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 5 records
- AKG · 2-oxoglutaric acid · in 1 record
- XKC · (2R)-2-hydroxy-2-[2-(2-methoxy-5-methylpyridin-3-yl)ethyl]butanedioic acid · in 1 record
- XKH · (2R,3S)-2,3-dimethylbutanedioic acid · in 1 record
Experiment against prediction
- 8UVD chain A against the predicted model Q8WWT9: TM-score 0.99, RMSD 0.79 Å
- 8UVG chain A against the predicted model Q8WWT9: TM-score 0.99, RMSD 0.79 Å
- 8UVF chain A against the predicted model Q8WWT9: TM-score 0.99, RMSD 0.80 Å
- 8UVE chain A against the predicted model Q8WWT9: TM-score 0.99, RMSD 0.80 Å
- 8UVC chain A against the predicted model Q8WWT9: TM-score 0.99, RMSD 0.79 Å
- 8UVE chain B against the predicted model Q8WWT9: TM-score 0.79, RMSD 4.35 Å
- 8UVI chain A against the predicted model Q8WWT9: TM-score 0.79, RMSD 4.29 Å
- 8UVG chain B against the predicted model Q8WWT9: TM-score 0.70, RMSD 4.86 Å
Elsewhere
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