UniProt Q8WR51
GDP-fucose protein O-fucosyltransferase 2,Spondin-1 (Q8WR51)
GDP-fucose protein O-fucosyltransferase 2,Spondin-1 (UniProt Q8WR51), EC 2.4.1.221: 3 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 20 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q8WR51
- Protein
- GDP-fucose protein O-fucosyltransferase 2,Spondin-1
- EC
- 2.4.1.221
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 20 · 2 records with a druggable one
Structures
4 records of Q8WR51 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5FOE | Crystal structure of the C. elegans Protein O-fucosyltransferase 2 (CePOFUT2) double mutant… | x-ray diffraction | A, B | NAG, GDP | — |
| 5FOE | Crystal structure of the C. elegans protein O-fucosyltransferase 2 (CEPOFUT2) double mutant… | x-ray diffraction | A, B | — | — |
| 8AY1 | Crystal structure of the C. elegans POFUT2 (CePoFUT2) triple mutant (R298K-R299K-A418C) in complex… | x-ray diffraction | A, B | NAG, SO4 | 14 (best 0.88) |
| Q8WR51 | AlphaFold monomer V2.0 prediction for GDP-fucose protein O-fucosyltransferase 2 (Q8WR51) | predicted | A | — | 6 (best 0.68) |
Ligands
Experiment against prediction
- 8AY1 chain B against the predicted model Q8WR51: TM-score 0.90, RMSD 0.86 Å
- 5FOE chain B against the predicted model Q8WR51: TM-score 0.88, RMSD 0.49 Å
- 5FOE chain B against the predicted model Q8WR51: TM-score 0.88, RMSD 0.49 Å
- 8AY1 chain A against the predicted model Q8WR51: TM-score 0.90, RMSD 1.15 Å
- 5FOE chain A against the predicted model Q8WR51: TM-score 0.88, RMSD 0.33 Å
- 5FOE chain A against the predicted model Q8WR51: TM-score 0.88, RMSD 0.33 Å
- 5FOE chain A against the predicted model P07996: TM-score 0.29, RMSD 7.26 Å
- 5FOE chain A against the predicted model P07996: TM-score 0.29, RMSD 7.26 Å
- 5FOE chain B against the predicted model P07996: TM-score 0.28, RMSD 7.21 Å
- 5FOE chain B against the predicted model P07996: TM-score 0.28, RMSD 7.21 Å
Elsewhere
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