UniProt Q8VHW8
Glutamate receptor 2, Voltage-dependent calcium channel gamma-5 subunit chimera (Q8VHW8)
Glutamate receptor 2, Voltage-dependent calcium channel gamma-5 subunit chimera (UniProt Q8VHW8): 10 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 199 pockets. Binding sites, druggability and…
- UniProt
- Q8VHW8
- Protein
- Glutamate receptor 2, Voltage-dependent calcium channel gamma-5 subunit chimera
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 199 · 10 records with a druggable one
Structures
11 records of Q8VHW8 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8SS2 | Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound… | electron microscopy | A, B, C, D | ZK1, PCW, CLR, AJP, SPD | 20 (best 0.85) |
| 8SS3 | Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and… | electron microscopy | A, B, C, D | ZK1, PCW, CLR, AJP, SPD | 20 (best 0.84) |
| 8SS4 | Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and… | electron microscopy | A, B, C, D | SPD | 19 (best 0.84) |
| 8SS5 | Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunit TARP gamma-5 (apo… | electron microscopy | A, B, C, D | — | 20 (best 0.85) |
| 8SS6 | Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound… | electron microscopy | A, B, C, D | 6ZP, ZK1, PCW, CLR, NA, SPD | 20 (best 0.84) |
| 8SS7 | Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound… | electron microscopy | A, B, C, D | 6ZP, ZK1, PCW, CLR, NA, SPD | 20 (best 0.84) |
| 8SS8 | Structure of AMPA receptor GluA2 complex with auxiliary subunit TARP gamma-5 bound to competitive… | electron microscopy | A, B, C, D | 6ZP, ZK1, PCW, NA, CLR | 20 (best 0.84) |
| 8SS9 | Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunit TARP gamma-5 bound to… | electron microscopy | A, B, C, D | 6ZP, ZK1, PCW, CLR, NA | 20 (best 0.84) |
| 8SSA | Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound… | electron microscopy | A, B, C, D | PCW, GLU, SPD | 20 (best 0.86) |
| 8SSB | Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and… | electron microscopy | A, B, C, D | PCW, GLU, SPD | 20 (best 0.86) |
| Q8VHW8 | AlphaFold monomer V2.0 prediction for voltage-dependent calcium channel gamma-5 subunit (Q8VHW8) | predicted | A | — | — |
Ligands
- PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · in 8 records
- SPD · Spermidine · in 7 records
- CLR · Cholesterol · in 6 records
- ZK1 · {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid · in 6 records
- 6ZP · 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile · in 4 records
- NA · Sodium ion · in 4 records
- AJP · Digitonin · in 2 records
- GLU · Glutamic acid · in 2 records
Experiment against prediction
- 8SS7 chain B against the predicted model P19491: TM-score 0.92, RMSD 2.30 Å
- 8SS7 chain D against the predicted model P19491: TM-score 0.92, RMSD 2.30 Å
- 8SS4 chain D against the predicted model P19491: TM-score 0.92, RMSD 2.32 Å
- 8SS4 chain B against the predicted model P19491: TM-score 0.92, RMSD 2.32 Å
- 8SS9 chain B against the predicted model P19491: TM-score 0.92, RMSD 2.35 Å
- 8SS9 chain D against the predicted model P19491: TM-score 0.92, RMSD 2.35 Å
- 8SS3 chain D against the predicted model P19491: TM-score 0.91, RMSD 2.39 Å
- 8SS3 chain B against the predicted model P19491: TM-score 0.91, RMSD 2.39 Å
- 8SS5 chain B against the predicted model P19491: TM-score 0.91, RMSD 2.40 Å
- 8SS5 chain D against the predicted model P19491: TM-score 0.91, RMSD 2.40 Å
Elsewhere
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