UniProt Q8U093
Tryptophan synthase beta chain 1 (Q8U093)
Tryptophan synthase beta chain 1 (UniProt Q8U093), EC 4.2.1.20: 34 experimental structures on GenesisL1, 7 ligands bound, 87 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q8U093
- Protein
- Tryptophan synthase beta chain 1
- EC
- 4.2.1.20
- Experimental structures
- 34
- Predicted models
- 0
- Ligands
- 7
- Pockets
- 87 · 6 records with a druggable one
Structures
34 records of Q8U093 in the MolNFT archive: 34 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1V8Z | X-ray crystal structure of the Tryptophan Synthase b2 Subunit from Hyperthermophile, Pyrococcus… | x-ray diffraction | A, B, C, D | — | — |
| 1V8Z | X-ray crystal structure of the tryptophan synthase B2 subunit from hyperthermophile, pyrococcus… | x-ray diffraction | A, B, C, D | — | — |
| 1WDW | Structural basis of mutual activation of the tryptophan synthase a2b2 complex from a… | x-ray diffraction | B, D, F, H, J, L | — | — |
| 1WDW | Structural basis of mutual activation of the tryptophan synthase A2B2 complex from a… | x-ray diffraction | B, D, F, H, J, L | — | — |
| 5DVZ | Holo trpb from pyrococcus furiosus | x-ray diffraction | A, B, C, D | — | — |
| 5DW0 | TrpB from Pyrococcus furiosus with L-serine bound as the external aldimine | x-ray diffraction | A, B, C, D | PLS, NA | 15 (best 0.82) |
| 5DW0 | Trpb from pyrococcus furiosus with L-serine bound as the external aldimine | x-ray diffraction | A, B, C, D | — | — |
| 5DW3 | Tryptophan Synthase beta-subunit from Pyrococcus furiosus with product L-tryptophan non-covalently… | x-ray diffraction | A, B, C, D | NA, PO4 | — |
| 5DW3 | Tryptophan synthase beta-subunit from pyrococcus furiosus with product L-tryptophan non-covalently… | x-ray diffraction | A, B, C, D | — | — |
| 5E0K | X-ray crystal structure of tryptophan synthase complex from pyrococcus furiosus at 2.76 a | x-ray diffraction | B, D, F, H, J, L | — | — |
| 5IXJ | Tryptophan Synthase beta-subunit from Pyrococcus furiosus with L-threonine non-covalently bound in… | x-ray diffraction | A, B, C, D | NA | — |
| 5IXJ | Tryptophan synthase beta-subunit from pyrococcus furiosus with L- threonine non-covalently bound in… | x-ray diffraction | A, B, C, D | — | — |
| 5T6M | Structure of the tryptophan synthase B-subunit from pyroccus furiosus with B-methyltryptophan… | x-ray diffraction | A, B, C, D | NA, PO4 | — |
| 5VM5 | Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB2B9, with Ser bound | x-ray diffraction | A, B, C, D | NA | — |
| 5VM5 | Engineered tryptophan synthase B-subunit from pyrococcus furiosus, PFTRPB2B9, with ser bound | x-ray diffraction | A, B, C, D | NA | — |
| 6AM7 | Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB2B9 | x-ray diffraction | A, B, C, D | NA, PO4 | 15 (best 0.83) |
| 6AM7 | Engineered tryptophan synthase B-subunit from pyrococcus furiosus, PFTRPB2B9 | x-ray diffraction | A, B, C, D | NA, PO4 | — |
| 6AM8 | Engineered tryptophan synthase B-subunit from pyrococcus furiosus, PFTRPB2B9 with TRP bound as… | x-ray diffraction | A, B, C, D | NA | — |
| 6AM9 | Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB2B9, with Ser-bound in a… | x-ray diffraction | A, B, C, D | NA, PLS, 0JO | 15 (best 0.82) |
| 6AM9 | Engineered tryptophan synthase B-subunit from pyrococcus furiosus, PFTRPB2B9, with ser-bound in a… | x-ray diffraction | A, B, C, D | NA | — |
| 6AMC | Engineered tryptophan synthase B-subunit from pyrococcus furiosus, PFTRPB4D11 | x-ray diffraction | A, B, C, D | NA | — |
| 6AMH | Engineered tryptophan synthase B-subunit from pyrococcus furiosus, PFTRPB4D11 with ser bound as… | x-ray diffraction | A, B, C, D | NA | — |
| 6AMI | Engineered tryptophan synthase B-subunit from pyrococcus furiosus, PFTRPB4D11 with TRP… | x-ray diffraction | A, B, C, D | NA | — |
| 6CUT | Engineered Holo TrpB from Pyrococcus furiosus, PfTrpB7E6 with (2S,3S)-isopropylserine bound as the… | x-ray diffraction | A, B, C, D | FEJ, NA | 13 (best 0.85) |
| 6CUT | Engineered holo trpb from pyrococcus furiosus, PFTRPB7E6 with (2S,3S)- isopropylserine bound as the… | x-ray diffraction | A, B, C, D | NA | — |
| 6CUV | Engineered Holo TrpB from Pyrococcus furiosus, PfTrpB7E6 | x-ray diffraction | A, B, C, D | NA, PO4 | 18 (best 0.81) |
| 6CUV | Engineered holo trpb from pyrococcus furiosus, PFTRPB7E6 | x-ray diffraction | A, B, C, D | NA, PO4 | — |
| 6CUZ | Engineered trpb from pyrococcus furiosus, PFTRPB7E6 with (2S,3R)- ethylserine bound as the… | x-ray diffraction | A, B, C, D | NA, FEV, PO4 | — |
| 7RNP | Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB2B9_H275E with 4-Cl-Trp… | x-ray diffraction | A, B, C, D | 6G5, NA | 11 (best 0.78) |
| 7RNP | Engineered tryptophan synthase B-subunit from pyrococcus furiosus, PFTRPB2B9_H275E with 4-cl-TRP… | x-ray diffraction | A, B, C, D | 6G5, NA | — |
| 7RNQ | Holo structure of engineered trpb, 2B9-H275E, from pyrococcus furiosus in the extended-open… | x-ray diffraction | A, B, C, D | PO4, NA | — |
| 7ROF | Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB2B9-H275E with L-Trp… | x-ray diffraction | A, B, C, D | NA | — |
| 7ROF | Engineered tryptophan synthase B-subunit from pyrococcus furiosus, PFTRPB2B9-H275E with L-TRP… | x-ray diffraction | A, B, C, D | NA | — |
| Q8U093 | AlphaFold monomer V2.0 prediction for tryptophan synthase beta chain 1 (Q8U093) | — | — | — |
Ligands
- NA · Sodium ion · in 24 records
- PO4 · Phosphate ion · in 8 records
- 6G5 · 4-chloro-L-tryptophan · in 2 records
- PLS · [3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-serine · in 2 records
- 0JO · 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid · in 1 record
- FEJ · (2S,3S)-3-hydroxy-2-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]-4-methylpentanoic acid (non-preferred name) · in 1 record
- FEV · (2E)-2-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy) methyl]pyridin-4-yl}methylidene)amino]pent-2-enoic acid · in 1 record
Elsewhere
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