UniProt Q8TDS4
Hydroxycarboxylic acid receptor 2 (Q8TDS4)
Hydroxycarboxylic acid receptor 2 (UniProt Q8TDS4): 21 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 107 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8TDS4
- Protein
- Hydroxycarboxylic acid receptor 2
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 107 · 22 records with a druggable one
Structures
22 records of Q8TDS4 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7XK2 | Cryo-EM Structure of Human Niacin Receptor HCA2-Gi protein complex | electron microscopy | R | FI7 | 5 (best 0.83) |
| 8H2G | Cryo-EM structure of niacin bound human hydroxy-carboxylic acid receptor 2 in complex with Gi… | electron microscopy | A | NIO | 6 (best 0.71) |
| 8IHB | Cryo-EM structure of HCA2-Gi complex with GSK256073 | electron microscopy | R | NAG, OKL | 4 (best 0.78) |
| 8IHF | Cryo-EM structure of HCA2-Gi complex with MK6892 | electron microscopy | R | NAG, FI7 | 3 (best 0.79) |
| 8IHI | Cryo-EM structure of HCA2-Gi complex with acifran | electron microscopy | R | NAG, P9X | 4 (best 0.79) |
| 8IJA | Cryo-EM structure of human HCAR2-Gi complex with niacin | electron microscopy | A | NIO | 6 (best 0.72) |
| 8IJB | Cryo-EM structure of human HCAR2-Gi complex with acipimox | electron microscopy | A | OJX | 5 (best 0.80) |
| 8IY9 | Structure of Niacin-GPR109A-G protein complex | electron microscopy | R | NIO | 6 (best 0.72) |
| 8IYH | Structure of MK6892-GPR109A-G-protein complex | electron microscopy | D | FI7 | 5 (best 0.82) |
| 8IYW | Structure of GSK256073-GPR109A-G-protein complex | electron microscopy | R | OKL | 7 (best 0.81) |
| 8J6I | Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound MK-6892 | electron microscopy | R | FI7 | 5 (best 0.78) |
| 8J6L | Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound niacin | electron microscopy | R | NIO | 8 (best 0.72) |
| 8J6P | Cryo-EM structure of the MK-6892-bound human HCAR2-Gi1 complex | electron microscopy | R | IX8, CLR, NIO, NAG | 4 (best 0.69) |
| 8J6Q | Cryo-EM structure of the 3-HB and compound 9n-bound human HCAR2-Gi1 complex | electron microscopy | R | IX8, CLR, 3HR, NAG | 4 (best 0.70) |
| 8JII | Cryo-EM structure of compound 9n and niacin bound ketone body receptor HCAR2-Gi signaling complex | electron microscopy | A | NIO, CLR, IX8 | 6 (best 0.72) |
| 8JIM | Cryo-EM structure of MMF bound ketone body receptor HCAR2-Gi signaling complex | electron microscopy | E | AW9, CLR | 5 (best 0.69) |
| 8JZ7 | Cryo-EM structure of MK-6892-bound HCAR2 in complex with Gi protein | electron microscopy | A | FI7 | 5 (best 0.82) |
| 8K5B | Cryo-EM structure of niacin bound human hydroxy-carboxylic acid receptor 2 (Local refinement) | electron microscopy | A | NIO | 4 (best 0.72) |
| 8K5C | Cryo-EM structure of Acipimox bound human hydroxy-carboxylic acid receptor 2 (Local refinement) | electron microscopy | A | OJX | 4 (best 0.70) |
| 8K5D | Cryo-EM structure of GSK256073 bound human hydroxy-carboxylic acid receptor 2 (Local refinement) | electron microscopy | A | OKL | 5 (best 0.79) |
| 9IQT | structure of niacin-HCA2-Gi | electron microscopy | R | NIO | 2 (best 0.72) |
| Q8TDS4 | AlphaFold monomer V2.0 prediction for hydroxycarboxylic acid receptor 2 (Q8TDS4) | predicted | A | — | 4 (best 0.74) |
Ligands
- NIO · Nicotinic acid · in 8 records
- FI7 · 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid · in 5 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 5 records
- CLR · Cholesterol · in 4 records
- IX8 · 7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide · in 3 records
- OKL · 8-chloranyl-3-pentyl-7H-purine-2,6-dione · in 3 records
- OJX · 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid · in 2 records
- 3HR · (3R)-3-hydroxybutanoic acid · in 1 record
- AW9 · (2Z)-4-methoxy-4-oxobut-2-enoic acid · in 1 record
- P9X · (5~{S})-5-methyl-4-oxidanylidene-5-phenyl-furan-2-carboxylic acid · in 1 record
Experiment against prediction
- 8J6Q chain R against the predicted model Q8TDS4: TM-score 0.96, RMSD 1.48 Å
- 8J6P chain R against the predicted model Q8TDS4: TM-score 0.96, RMSD 1.51 Å
- 8IHF chain R against the predicted model Q8TDS4: TM-score 0.95, RMSD 1.50 Å
- 8K5C chain A against the predicted model Q8TDS4: TM-score 0.95, RMSD 1.52 Å
- 8IHI chain R against the predicted model Q8TDS4: TM-score 0.95, RMSD 1.52 Å
- 8IJA chain A against the predicted model Q8TDS4: TM-score 0.95, RMSD 1.57 Å
- 8IY9 chain R against the predicted model Q8TDS4: TM-score 0.95, RMSD 1.55 Å
- 9IQT chain R against the predicted model Q8TDS4: TM-score 0.95, RMSD 1.54 Å
- 8IHB chain R against the predicted model Q8TDS4: TM-score 0.95, RMSD 1.57 Å
- 8IYH chain D against the predicted model Q8TDS4: TM-score 0.95, RMSD 1.55 Å
Elsewhere
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