UniProt Q8TD43
Transient receptor potential cation channel subfamily M member 4 (Q8TD43)
Transient receptor potential cation channel subfamily M member 4 (UniProt Q8TD43): 18 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 291 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q8TD43
- Protein
- Transient receptor potential cation channel subfamily M member 4
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 291 · 16 records with a druggable one
Structures
19 records of Q8TD43 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5WP6 | Cryo-EM structure of a human TRPM4 channel in complex with calcium and decavanadate | electron microscopy | A, B, C, D | DVT | 20 (best 0.86) |
| 5WP6 | Cryo-EM structure of a human TRPM4 channel in complex with calcium and decavanadate | electron microscopy | A, B, C, D | DVT | — |
| 6BQR | Human TRPM4 ion channel in lipid nanodiscs in a calcium-free state | electron microscopy | A, B, C, D | Y01 | 20 (best 0.84) |
| 6BQR | Human TRPM4 ion channel in lipid nanodiscs in a calcium-free state | electron microscopy | A, B, C, D | Y01 | — |
| 6BQV | Human TRPM4 ion channel in lipid nanodiscs in a calcium-bound state | electron microscopy | A, B, C, D | CA, Y01 | 20 (best 0.84) |
| 6BQV | Human TRPM4 ion channel in lipid nanodiscs in a calcium-bound state | electron microscopy | A, B, C, D | CA, Y01 | — |
| 8RCR | human TRPM4 in SMA apo | electron microscopy | A, B, C, D | CLR | 20 (best 0.84) |
| 8RCU | human TRPM4 in SMA IBA | electron microscopy | A, B, C, D | A1HZ5, CLR | 20 (best 0.83) |
| 8RD9 | human TRPM4 in SMA NBA | electron microscopy | A, E, C, D | A1H0C, CLR | 20 (best 0.85) |
| 9B8W | Cryo-EM structure of the human TRPM4 in complex with calcium at 37 degrees Celsius | electron microscopy | A, B, C, D | CA | 20 (best 0.86) |
| 9B8X | Cryo-EM structure of the human TRPM4 channel subunit in complex with calcium 37 degrees Celsius | electron microscopy | A | CA | 12 (best 0.75) |
| 9B8Y | Cryo-EM structure of the human TRPM4 channel in complex with calcium and decavanadate at 37 degrees… | electron microscopy | A, B, C, D | CA, DVT | 20 (best 0.85) |
| 9B8Z | Cryo-EM structure of the human TRPM4 channel subunit in complex with calcium and decavanadate at 37… | electron microscopy | A | CA, DVT | 6 (best 0.77) |
| 9B90 | Cryo-EM structure of the human TRPM4 channel in complex with calcium and ATP at 37 degrees Celsius | electron microscopy | A, B, C, D | CA, ATP | 20 (best 0.84) |
| 9B91 | Cryo-EM structure of the human TRPM4 channel subunit in complex with calcium and ATP at 37 degrees… | electron microscopy | A | CA, ATP | 15 (best 0.76) |
| 9B92 | Cryo-EM structure of the human TRPM4 in complex with calcium at 18 degrees Celsius | electron microscopy | A, B, C, D | CA | 20 (best 0.87) |
| 9B93 | Cryo-EM structure of the human TRPM4 channel in the presence of EDTA at 37 degrees Celsius | electron microscopy | A, B, C, D | — | 20 (best 0.83) |
| 9B94 | Cryo-EM structure of the E396A mutant of human TRPM4 in complex with calcium at 37 degrees Celsius | electron microscopy | A, B, C, D | CA | 20 (best 0.86) |
| Q8TD43 | AlphaFold monomer V2.0 prediction for transient receptor potential cation channel subfamily M… | predicted | A | — | 18 (best 0.81) |
Ligands
- CA · Calcium ion · in 10 records
- DVT · Decavanadate · in 4 records
- Y01 · Cholesterol hemisuccinate · in 4 records
- CLR · Cholesterol · in 3 records
- ATP · Adenosine-5'-triphosphate · in 2 records
- A1H0C · 4-chloranyl-2-(2-naphthalen-1-yloxyethanoylamino)benzoic acid · in 1 record
- A1HZ5 · 4-chloranyl-2-[2-(3-iodanylphenoxy)ethanoylamino]benzoic acid · in 1 record
Experiment against prediction
- 8RCU chain A against the predicted model Q8TD43: TM-score 0.91, RMSD 2.79 Å
- 8RD9 chain A against the predicted model Q8TD43: TM-score 0.91, RMSD 2.82 Å
- 8RCR chain A against the predicted model Q8TD43: TM-score 0.91, RMSD 2.82 Å
- 8RCR chain C against the predicted model Q8TD43: TM-score 0.91, RMSD 2.82 Å
- 8RD9 chain D against the predicted model Q8TD43: TM-score 0.91, RMSD 2.82 Å
- 8RD9 chain E against the predicted model Q8TD43: TM-score 0.91, RMSD 2.82 Å
- 8RD9 chain C against the predicted model Q8TD43: TM-score 0.91, RMSD 2.83 Å
- 8RCR chain B against the predicted model Q8TD43: TM-score 0.91, RMSD 2.83 Å
- 8RCR chain D against the predicted model Q8TD43: TM-score 0.91, RMSD 2.83 Å
- 9B94 chain A against the predicted model Q8TD43: TM-score 0.87, RMSD 4.42 Å
Elsewhere
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