UniProt Q8R4B8

NACHT, LRR and PYD domains-containing protein 3 (Q8R4B8)

NACHT, LRR and PYD domains-containing protein 3 (UniProt Q8R4B8): 4 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 52 pockets. Binding sites, druggability and experiment against prediction (TM-score)…

UniProt: Q8R4B8
Protein: NACHT, LRR and PYD domains-containing protein 3
Experimental structures: 4
Predicted models: 1
Ligands: 2
Pockets: 52 · 3 records with a druggable one

Structures

5 records of Q8R4B8 in the MolNFT archive: 4 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
7LFH	Cryo-EM structure of NLRP3 double-ring cage, 6-fold (12-mer)	electron microscopy	A, B, C, D, E, F, G, H, I, J, K, L	—	20 (best 0.88)
7LFH	Cryo-EM structure of NLRP3 double-ring cage, 6-fold (12-mer)	electron microscopy	A, B, C, D, E, F, G, H, I, J, K, L	—	—
7VTQ	Cryo-EM structure of mouse NLRP3 (full-length) dodecamer	electron microscopy	A, B, C, D, E, F, G, H, I, J, K, L	ADP, 7YN	20 (best 0.82)
7VTQ	Cryo-EM structure of mouse NLRP3 (full-length) dodecamer	electron microscopy	A, B, C, D, E, F, G, H, I, J, K, L	ADP, 7YN	—
Q8R4B8	AlphaFold monomer V2.0 prediction for nacht, lrr and pyd domains- containing protein 3 (Q8R4B8)	predicted	A	—	12 (best 0.83)

Ligands

7YN · 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2, 3,5-tetrahydro-S-indacen-4-yl)urea · in 2 records
ADP · Adenosine-5'-diphosphate · in 2 records

Experiment against prediction

7VTQ chain I against the predicted model Q8R4B8: TM-score 0.75, RMSD 4.51 Å
7VTQ chain C against the predicted model Q8R4B8: TM-score 0.75, RMSD 4.51 Å
7VTQ chain F against the predicted model Q8R4B8: TM-score 0.75, RMSD 4.51 Å
7VTQ chain H against the predicted model Q8R4B8: TM-score 0.75, RMSD 4.51 Å
7VTQ chain E against the predicted model Q8R4B8: TM-score 0.75, RMSD 4.51 Å
7VTQ chain B against the predicted model Q8R4B8: TM-score 0.75, RMSD 4.51 Å
7VTQ chain L against the predicted model Q8R4B8: TM-score 0.75, RMSD 4.51 Å
7VTQ chain K against the predicted model Q8R4B8: TM-score 0.75, RMSD 4.51 Å
7VTQ chain D against the predicted model Q8R4B8: TM-score 0.75, RMSD 4.51 Å
7VTQ chain A against the predicted model Q8R4B8: TM-score 0.75, RMSD 4.51 Å

Elsewhere

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