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Ligand · 7YN

7YN · 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2, 3,5-tetrahydro-S-indacen-4-yl)urea

7YN, 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2, 3,5-tetrahydro-S-indacen-4-yl)urea (C20 H22 N2 O5 S, 402.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (2 PDB entries). Every binding site with its residues…

Component
7YN
Formula
C20 H22 N2 O5 S
Class
ligand
Structures
2
PDB entries
2

Binding sites

7YN in 2 structures; the first of them:

  • 7VTP · Cryo-EM structure of pyd-deleted human NLRP3 hexamer · 7YN A1502 · binds ALA227, ALA228, ARG351, PRO352, ILE411, VAL414, THR439, TYR443 and 5 more
  • 7VTQ · Cryo-EM structure of mouse NLRP3 (full-length) dodecamer · 7YN A1502 · binds GLY222, ALA223, ALA224, ARG347, VAL349, ILE407, PHE573, ARG576 and 4 more

Residues it binds most

ALA 18, ARG 18, TYR 18, GLU 18, ILE 18, PHE 18, VAL 18, MET 14, GLY 12, LEU 12 (residue and the binding sites it lines).

Found with

  • ADP · Adenosine-5'-diphosphate

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