MolNFT v1 · #180936 · protein
Cryo-EM structure of NLRP3 double-ring cage, 6-fold (12-mer)
7LFH · Nacht, lrr and pyd domains-containing protein 3: “Cryo-EM structure of NLRP3 double-ring cage, 6-fold (12-mer)”. Electron microscopy, 20 pockets (best druggability 0.88). MolNFT v1 #180936 on GenesisL1: 3D structure, binding sites…
- PDB
- 7LFH
- Type
- protein
- Length
- 9,672 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nacht, lrr and pyd domains-containing protein 3
- UniProt
- Q8R4B8
- Pockets
- 20 · best druggability 0.88
Structure
electron microscopy · 1 distinct chain · 41% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L | Nacht, lrr and pyd domains-containing protein 3 | protein | 806 | 41% helix, 10% strand | Q8R4B8 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 825 | 0.88 | 0.90 | 106 | empty |
| 2 | 755 | 0.88 | 0.91 | 103 | empty |
| 3 | 697 | 0.87 | 0.91 | 108 | empty |
| 4 | 949 | 0.87 | 0.88 | 117 | empty |
| 5 | 1012 | 0.87 | 0.88 | 124 | empty |
Interfaces
24 interfaces between chains.
- H–I · 1587 Ų buried · 4 hydrogen bonds · protein-protein
- D–E · 1572 Ų buried · 4 hydrogen bonds · protein-protein
- A–L · 1558 Ų buried · 4 hydrogen bonds · protein-protein
- F–G · 1551 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 1538 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 7LFH · Cryo-EM structure of NLRP3 double-ring cage, 6-fold (12-mer) · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8R4B8
- Elsewhere: RCSB PDB 7LFH · PDBe 7LFH · UniProt Q8R4B8
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