UniProt Q8R0I0
Angiotensin-converting enzyme 2 (Q8R0I0)
Angiotensin-converting enzyme 2 (UniProt Q8R0I0), EC 3.4.17.-, 3.4.17.23: 25 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 68 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q8R0I0
- Protein
- Angiotensin-converting enzyme 2
- EC
- 3.4.17.-, 3.4.17.23
- Experimental structures
- 25
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 68 · 14 records with a druggable one
Structures
26 records of Q8R0I0 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7FDK | SARS-COV-2 Spike RBDMACSp36 binding to mACE2 | electron microscopy | A | NAG | 5 (best 0.71) |
| 7FDK | SARS-cov-2 spike RBDMACSP36 binding to MACE2 | electron microscopy | A | NAG | — |
| 7WRH | Cryo-EM structure of SARS-CoV-2 Omicron BA.1 spike protein in complex with mouse ACE2 | electron microscopy | D | ZN | 3 (best 0.76) |
| 7WRI | Cryo-EM structure of SARS-cov-2 omicron spike receptor-binding domain in complex with mouse ACE2 | electron microscopy | A | ZN | — |
| 7XO4 | SARS-CoV-2 Omicron BA.1 Variant Spike Trimer with two mouse ACE2 Bound | electron microscopy | D, E | ZN, NAG | 6 (best 0.73) |
| 7XO4 | SARS-cov-2 omicron BA.1 variant spike trimer with two mouse ACE2 bound | electron microscopy | D, E | ZN, NAG | — |
| 7XO5 | SARS-CoV-2 Omicron BA.1 Variant Spike Trimer with one mouse ACE2 Bound | electron microscopy | D | ZN, NAG | — |
| 7XO5 | SARS-cov-2 omicron BA.1 variant spike trimer with one mouse ACE2 bound | electron microscopy | D | ZN, NAG | — |
| 7XO6 | SARS-CoV-2 Omicron BA.1 Variant RBD with mouse ACE2 Bound | electron microscopy | D | NAG, ZN | 5 (best 0.67) |
| 7XO6 | SARS-cov-2 omicron BA.1 variant rbd with mouse ACE2 bound | electron microscopy | D | NAG, ZN | — |
| 7XOA | SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with one mouse ACE2 Bound | electron microscopy | D | ZN, NAG | 3 (best 0.68) |
| 7XOA | SARS-cov-2 omicron BA.2 variant spike trimer with one mouse ACE2 bound | electron microscopy | D | ZN, NAG | — |
| 7XOB | SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with two mouse ACE2 Bound | electron microscopy | D, E | ZN, NAG | 4 (best 0.68) |
| 7XOB | SARS-cov-2 omicron BA.2 variant spike trimer with two mouse ACE2 bound | electron microscopy | D, E | ZN, NAG | — |
| 7XOC | SARS-CoV-2 Omicron BA.2 Variant RBD complexed with mouse ACE2 | electron microscopy | D | NAG, ZN | 5 (best 0.69) |
| 7XOC | SARS-cov-2 omicron BA.2 variant rbd complexed with mouse ACE2 | electron microscopy | D | NAG, ZN | — |
| 8AQT | Beta SARS-CoV-2 Spike bound to mouse ACE2 (local) | electron microscopy | A | NAG | 13 (best 0.89) |
| 8AQV | BA.2.12.1 SARS-CoV-2 Spike bound to mouse ACE2 (local) | electron microscopy | A | NAG | — |
| 8AQW | BA.4/5 SARS-CoV-2 Spike bound to mouse ACE2 (local) | electron microscopy | A | NAG | 7 (best 0.81) |
| 8DM7 | Cryo-EM structure of SARS-CoV-2 Omicron BA.2 spike protein in complex with mouse ACE2 | electron microscopy | D, E | NAG | — |
| 8DM8 | Cryo-EM structure of SARS-CoV-2 Omicron BA.2 spike protein in complex with mouse ACE2 (focused… | electron microscopy | D | NAG | 4 (best 0.65) |
| 8DM9 | Cryo-EM structure of SARS-CoV-2 Omicron BA.1 spike protein in complex with mouse ACE2 | electron microscopy | D | NAG | 2 (best 0.74) |
| 8VKL | Cryo-EM structure of SARS-CoV-2 XBB.1.5 spike protein in complex with mouse ACE2 (conformation 2) | electron microscopy | D, F | NAG | 5 (best 0.70) |
| 8VKM | Cryo-EM structure of SARS-CoV-2 XBB.1.5 spike protein in complex with mouse ACE2 (conformation 1) | electron microscopy | D | NAG | 2 (best 0.68) |
| 8VKN | Cryo-EM structure of SARS-CoV-2 XBB.1.5 spike protein in complex with mouse ACE2 (focused… | electron microscopy | D | NAG | 4 (best 0.71) |
| Q8R0I0 | AlphaFold monomer V2.0 prediction for angiotensin-converting enzyme 2 (Q8R0I0) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8AQV chain A against the predicted model Q8R0I0: TM-score 0.98, RMSD 1.10 Å
- 8AQW chain A against the predicted model Q8R0I0: TM-score 0.98, RMSD 1.15 Å
- 7FDK chain A against the predicted model Q8R0I0: TM-score 0.96, RMSD 1.88 Å
- 7FDK chain A against the predicted model Q8R0I0: TM-score 0.96, RMSD 1.88 Å
- 8DM9 chain D against the predicted model Q8R0I0: TM-score 0.95, RMSD 1.97 Å
- 8DM7 chain E against the predicted model Q8R0I0: TM-score 0.95, RMSD 2.03 Å
- 8DM8 chain D against the predicted model Q8R0I0: TM-score 0.95, RMSD 2.13 Å
- 8DM7 chain D against the predicted model Q8R0I0: TM-score 0.95, RMSD 2.13 Å
- 8VKL chain D against the predicted model Q8R0I0: TM-score 0.94, RMSD 2.24 Å
- 8VKM chain D against the predicted model Q8R0I0: TM-score 0.94, RMSD 2.24 Å
Elsewhere
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