UniProt Q8NBK3
Formylglycine-generating enzyme (Q8NBK3)
Formylglycine-generating enzyme (UniProt Q8NBK3), EC 1.8.3.7: 20 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 13 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q8NBK3
- Protein
- Formylglycine-generating enzyme
- EC
- 1.8.3.7
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 13 · 5 records with a druggable one
Structures
21 records of Q8NBK3 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1Y1E | human formylglycine generating enzyme | x-ray diffraction | X | — | — |
| 1Y1E | Human formylglycine generating enzyme | x-ray diffraction | X | — | — |
| 2AFT | Formylglycine generating enzyme C336S mutant | x-ray diffraction | X | — | — |
| 2AFT | Formylglycine generating enzyme C336S mutant | x-ray diffraction | X | — | — |
| 2AFY | Formylglycine generating enzyme C341S mutant | x-ray diffraction | X | — | — |
| 2AFY | Formylglycine generating enzyme C341S mutant | x-ray diffraction | X | — | — |
| 2AII | wild-type Formylglycine generating enzyme reacted with iodoacetamide | x-ray diffraction | X | — | — |
| 2AII | Wild-type formylglycine generating enzyme reacted with iodoacetamide | x-ray diffraction | X | — | — |
| 2AIJ | Formylglycine generating enzyme C336S mutant covalently bound to substrate peptide CTPSR | x-ray diffraction | X | — | — |
| 2AIJ | Formylglycine generating enzyme C336S mutant covalently bound to substrate peptide ctpsr | x-ray diffraction | X | — | — |
| 2AIK | Formylglycine generating enzyme C336S mutant covalently bound to substrate peptide LCTPSRA | x-ray diffraction | X | — | — |
| 2AIK | Formylglycine generating enzyme C336S mutant covalently bound to substrate peptide lctpsra | x-ray diffraction | X | — | — |
| 2HI8 | human formylglycine generating enzyme, C336S mutant, bromide co-crystallization | x-ray diffraction | X | — | — |
| 2HI8 | Human formylglycine generating enzyme, C336S mutant, bromide co- crystallization | x-ray diffraction | X | — | — |
| 2HIB | human formylglycine generating enzyme, C336S mutant, iodide co-crystallization | x-ray diffraction | X | — | — |
| 2HIB | Human formylglycine generating enzyme, C336S mutant, iodide co- crystallization | x-ray diffraction | X | — | — |
| 5SSX | Crystal Structure human formylglycine generating enzyme E130D mutant | x-ray diffraction | A | NAG, CU1, CA | 2 (best 0.54) |
| 5SSY | Crystal Structure of human formylglycine generating enzyme | x-ray diffraction | A | CU1, NAG, CA, UG6 | 3 (best 0.51) |
| 5SSZ | Crystal Structure of wild-type human formylglycine generating enzyme bound to Cu(I) | x-ray diffraction | A | CU1, NAG, CA | 3 (best 0.51) |
| 8ARU | Crystal Structure of human formylglycine generating enzyme | x-ray diffraction | A | NAG, CA | 2 (best 0.53) |
| Q8NBK3 | AlphaFold monomer V2.0 prediction for formylglycine-generating enzyme (Q8NBK3) | predicted | A | — | 3 (best 0.51) |
Ligands
Experiment against prediction
- 1Y1E chain X against the predicted model Q8NBK3: TM-score 1.00, RMSD 0.23 Å
- 1Y1E chain X against the predicted model Q8NBK3: TM-score 1.00, RMSD 0.23 Å
- 2AIJ chain X against the predicted model Q8NBK3: TM-score 1.00, RMSD 0.33 Å
- 2AIJ chain X against the predicted model Q8NBK3: TM-score 1.00, RMSD 0.33 Å
- 2AIK chain X against the predicted model Q8NBK3: TM-score 1.00, RMSD 0.34 Å
- 2AIK chain X against the predicted model Q8NBK3: TM-score 1.00, RMSD 0.34 Å
- 2HIB chain X against the predicted model Q8NBK3: TM-score 1.00, RMSD 0.35 Å
- 2HIB chain X against the predicted model Q8NBK3: TM-score 1.00, RMSD 0.35 Å
- 2AFT chain X against the predicted model Q8NBK3: TM-score 1.00, RMSD 0.37 Å
- 2AFT chain X against the predicted model Q8NBK3: TM-score 1.00, RMSD 0.37 Å
Elsewhere
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