UniProt Q8NB78
Lysine-specific histone demethylase 1B (Q8NB78)
Lysine-specific histone demethylase 1B (UniProt Q8NB78), EC 1.14.99.66: 26 experimental structures on GenesisL1, 4 ligands bound, 28 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q8NB78
- Protein
- Lysine-specific histone demethylase 1B
- EC
- 1.14.99.66
- Experimental structures
- 26
- Predicted models
- 0
- Ligands
- 4
- Pockets
- 28 · 2 records with a druggable one
Structures
26 records of Q8NB78 in the MolNFT archive: 26 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4FWE | Native structure of LSD2 /AOF1/KDM1b in spacegroup of C2221 at 2.13A | x-ray diffraction | A | — | — |
| 4FWE | Native structure of LSD2 /AOF1/KDM1B in spacegroup of C2221 at 2.13A | x-ray diffraction | A | — | — |
| 4FWF | Complex structure of LSD2/AOF1/KDM1b with H3K4 mimic | x-ray diffraction | A | — | — |
| 4FWF | Complex structure of LSD2/AOF1/KDM1B with H3K4 mimic | x-ray diffraction | A | — | — |
| 4FWJ | Native structure of LSD2/AOF1/KDM1b in spacegroup of I222 at 2.9A | x-ray diffraction | A, B | — | — |
| 4FWJ | Native structure of LSD2/AOF1/KDM1B in spacegroup of I222 at 2.9A | x-ray diffraction | A, B | — | — |
| 4GU0 | Crystal structure of LSD2 with H3 | x-ray diffraction | A, B, C, D | — | — |
| 4GU0 | Crystal structure of LSD2 with H3 | x-ray diffraction | A, B, C, D | — | — |
| 4GU1 | Crystal structure of LSD2 | x-ray diffraction | A, B | — | — |
| 4GU1 | Crystal structure of LSD2 | x-ray diffraction | A, B | — | — |
| 4GUR | Crystal structure of LSD2-NPAC with H3 in space group P21 | x-ray diffraction | A | — | — |
| 4GUR | Crystal structure of LSD2-npac with H3 in space group P21 | x-ray diffraction | A | — | — |
| 4GUS | Crystal structure of LSD2-NPAC with H3 in space group P3221 | x-ray diffraction | A | — | — |
| 4GUS | Crystal structure of LSD2-npac with H3 in space group P3221 | x-ray diffraction | A | — | — |
| 4GUT | Crystal structure of LSD2-NPAC | x-ray diffraction | A | — | — |
| 4GUT | Crystal structure of LSD2-npac | x-ray diffraction | A | — | — |
| 4GUU | Crystal structure of LSD2-NPAC with tranylcypromine | x-ray diffraction | A | — | — |
| 4GUU | Crystal structure of LSD2-npac with tranylcypromine | x-ray diffraction | A | — | — |
| 4HSU | Crystal structure of LSD2-NPAC with H3(1-26)in space group P21 | x-ray diffraction | A | — | — |
| 4HSU | Crystal structure of LSD2-npac with H3(1-26)IN space group P21 | x-ray diffraction | A | — | — |
| 6R1U | Structure of LSD2/NPAC-LINKER/NUCLEOSOME core particle complex: class 2 | electron microscopy | K | FAD, ZN | — |
| 6R25 | Structure of LSD2/NPAC-LINKER/NUCLEOSOME core particle complex: class 3 | electron microscopy | K | FAD, ZN | — |
| 7XE1 | Crystal structure of LSD2 in complex with cis-4-Br-PCPA | x-ray diffraction | A, B | ZN, FAD, DIJ | — |
| 7XE2 | Crystal structure of LSD2 in complex with trans-4-Br-PCPA | x-ray diffraction | A, B | ZN, FAD, DIJ | 15 (best 0.81) |
| 7XE3 | Crystal structure of LSD2 in complex with cis-4-Br-2,5-F2-PCPA (S1024) | x-ray diffraction | A, B | ZN, FAD, 8A2 | 13 (best 0.82) |
| Q8NB78 | AlphaFold monomer V2.0 prediction for lysine-specific histone demethylase 1B (Q8NB78) | — | — | — |
Ligands
Elsewhere
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