UniProt Q8N4P3
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (Q8N4P3)
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (UniProt Q8N4P3), EC 3.1.7.2: 4 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 4 pockets. Binding sites, druggability and experiment…
- UniProt
- Q8N4P3
- Protein
- Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1
- EC
- 3.1.7.2
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 4 · 1 record with a druggable one
Structures
5 records of Q8N4P3 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3NR1 | A metazoan ortholog of SpoT hydrolyzes ppGpp and plays a role in starvation responses | x-ray diffraction | A, B | — | — |
| 3NR1 | A metazoan ortholog of spot hydrolyzes ppgpp and plays a role in starvation responses | x-ray diffraction | A, B | — | — |
| 5VXA | Structure of the human Mesh1-NADPH complex | x-ray diffraction | A, B | ZN, NDP | 4 (best 0.71) |
| 5VXA | Structure of the human MESH1-NADPH complex | x-ray diffraction | A, B | ZN, NDP | — |
| Q8N4P3 | AlphaFold monomer V2.0 prediction for guanosine-3',5'-BIS(DIPHOSPHATE) 3'-pyrophosphohydrolase… | predicted | A | — | — |
Ligands
Experiment against prediction
- 5VXA chain A against the predicted model Q8N4P3: TM-score 1.00, RMSD 0.21 Å
- 5VXA chain A against the predicted model Q8N4P3: TM-score 1.00, RMSD 0.21 Å
- 5VXA chain B against the predicted model Q8N4P3: TM-score 1.00, RMSD 0.29 Å
- 3NR1 chain A against the predicted model Q8N4P3: TM-score 0.99, RMSD 0.45 Å
- 3NR1 chain A against the predicted model Q8N4P3: TM-score 0.99, RMSD 0.45 Å
Elsewhere
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