UniProt Q8MNT9
DNA N6-methyl adenine demethylase (Q8MNT9)
DNA N6-methyl adenine demethylase (UniProt Q8MNT9), EC 1.14.11.51: 4 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 24 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q8MNT9
- Protein
- DNA N6-methyl adenine demethylase
- EC
- 1.14.11.51
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 24 · 5 records with a druggable one
Structures
5 records of Q8MNT9 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8H68 | Crystal structure of Caenorhabditis elegans NMAD-1 in complex with NOG and Mg(II) | x-ray diffraction | A | GLC, GLY, OGA, MG | 6 (best 0.74) |
| 8HAZ | Crystal structure of Caenorhabditis elegans NMAD-1 in complex with ligand I | x-ray diffraction | A | SO4 | 1 (best 0.60) |
| 8HB2 | Crystal structure of Caenorhabditis elegans NMAD-1 in complex with ligand II | x-ray diffraction | A, B, C, D | MN, AKG | 6 (best 0.62) |
| 8HBB | Crystal structure of Caenorhabditis elegans NMAD-1 in complex with ligand III | x-ray diffraction | A, B, C, D | MN, CL | 9 (best 0.71) |
| Q8MNT9 | AlphaFold monomer V2.0 prediction for DNA N6-methyl adenine demethylase (Q8MNT9) | predicted | A | — | 2 (best 0.62) |
Ligands
Experiment against prediction
- 8HB2 chain C against the predicted model Q8MNT9: TM-score 0.99, RMSD 0.64 Å
- 8HBB chain C against the predicted model Q8MNT9: TM-score 0.99, RMSD 0.67 Å
- 8HB2 chain D against the predicted model Q8MNT9: TM-score 0.99, RMSD 0.68 Å
- 8HBB chain D against the predicted model Q8MNT9: TM-score 0.99, RMSD 0.73 Å
- 8HB2 chain B against the predicted model Q8MNT9: TM-score 0.99, RMSD 0.73 Å
- 8HBB chain B against the predicted model Q8MNT9: TM-score 0.98, RMSD 0.76 Å
- 8HB2 chain A against the predicted model Q8MNT9: TM-score 0.98, RMSD 0.76 Å
- 8HBB chain A against the predicted model Q8MNT9: TM-score 0.98, RMSD 0.79 Å
- 8HAZ chain A against the predicted model Q8MNT9: TM-score 0.97, RMSD 0.98 Å
- 8H68 chain A against the predicted model Q8MNT9: TM-score 0.41, RMSD 1.49 Å
Elsewhere
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