UniProt Q8IW19
Aprataxin and PNK-like factor (Q8IW19)
Aprataxin and PNK-like factor (UniProt Q8IW19), EC 4.2.99.18: 22 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q8IW19
- Protein
- Aprataxin and PNK-like factor
- EC
- 4.2.99.18
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 5 · 3 records with a druggable one
Structures
23 records of Q8IW19 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KQB | First PBZ domain of human APLF protein | solution nmr | A | — | — |
| 2KQB | First pbz domain of human aplf protein | solution nmr | A | — | — |
| 2KQC | Second PBZ domain of human APLF protein | solution nmr | A | — | — |
| 2KQC | Second pbz domain of human aplf protein | solution nmr | A | — | — |
| 2KQD | First PBZ domain of human APLF protein in complex with ribofuranosyladenosine | solution nmr | A | — | — |
| 2KQD | First pbz domain of human aplf protein in complex with ribofuranosyladenosine | solution nmr | A | — | — |
| 2KQE | Second PBZ domain of human APLF protein in complex with ribofuranosyladenosine | solution nmr | A | — | — |
| 2KQE | Second pbz domain of human aplf protein in complex with ribofuranosyladenosine | solution nmr | A | — | — |
| 2KUO | Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage… | solution nmr | A | — | — |
| 2KUO | Structure and identification of ADP-ribose recognition motifs of aplf and role in the DNA damage… | solution nmr | A | — | — |
| 5E50 | APLF/XRCC4 complex | x-ray diffraction | A, B | — | — |
| 5E50 | APLF/XRCC4 complex | x-ray diffraction | A, B | — | — |
| 5W7W | Crystal Structure of FHA domain of human APLF | x-ray diffraction | T, A | NA | 1 (best 0.53) |
| 5W7W | Crystal structure of fha domain of human aplf | x-ray diffraction | T, A | NA | — |
| 5W7X | Crystal Structure of FHA domain of human APLF in complex with XRCC1 bisphospho peptide | x-ray diffraction | D, A, B, C | — | 3 (best 0.69) |
| 5W7X | Crystal structure of fha domain of human aplf in complex with XRCC1 bisphospho peptide | x-ray diffraction | D, A, B, C | — | — |
| 5W7Y | Crystal Structure of FHA domain of human APLF in complex with XRCC1 monophosphorylated mutated… | x-ray diffraction | A, B | — | 1 (best 0.67) |
| 5W7Y | Crystal structure of fha domain of human aplf in complex with XRCC1 monophosphorylated mutated… | x-ray diffraction | A, B | — | — |
| 6ERF | Complex of APLF factor and Ku heterodimer bound to DNA | x-ray diffraction | Q, R, S, T | — | — |
| 6ERF | Complex of aplf factor and ku heterodimer bound to DNA | x-ray diffraction | Q, R, S, T | — | — |
| 6YN1 | Crystal structure of histone chaperone APLF acidic domain bound to the histone H2A-H2B-H3-H4 octamer | x-ray diffraction | E, J, O, T, Y, d, i, n | CL | — |
| 6YN1 | Crystal structure of histone chaperone aplf acidic domain bound to the histone H2A-H2B-H3-H4 octamer | x-ray diffraction | E, J, O, T, Y, d, i, n | CL | — |
| Q8IW19 | AlphaFold monomer V2.0 prediction for aprataxin and pnk-like factor (Q8IW19) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5W7X chain B against the predicted model Q8IW19: TM-score 0.98, RMSD 0.75 Å
- 5W7X chain B against the predicted model Q8IW19: TM-score 0.98, RMSD 0.75 Å
- 5W7X chain D against the predicted model Q8IW19: TM-score 0.98, RMSD 0.72 Å
- 5W7X chain D against the predicted model Q8IW19: TM-score 0.98, RMSD 0.72 Å
- 5W7X chain C against the predicted model Q8IW19: TM-score 0.98, RMSD 0.79 Å
- 5W7X chain C against the predicted model Q8IW19: TM-score 0.98, RMSD 0.79 Å
- 5W7W chain T against the predicted model Q8IW19: TM-score 0.98, RMSD 0.43 Å
- 5W7W chain T against the predicted model Q8IW19: TM-score 0.98, RMSD 0.43 Å
- 5W7Y chain A against the predicted model Q8IW19: TM-score 0.97, RMSD 1.09 Å
- 5W7Y chain A against the predicted model Q8IW19: TM-score 0.97, RMSD 1.09 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.