UniProt Q8IVV7
Glucose-induced degradation protein 4 homolog (Q8IVV7)
Glucose-induced degradation protein 4 homolog (UniProt Q8IVV7): 36 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 51 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q8IVV7
- Protein
- Glucose-induced degradation protein 4 homolog
- Experimental structures
- 36
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 51 · 11 records with a druggable one
Structures
37 records of Q8IVV7 in the MolNFT archive: 36 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6CCR | Selenomethionyl derivative of a GID4 fragment | x-ray diffraction | A | UNX | — |
| 6CCR | Selenomethionyl derivative of a GID4 fragment | x-ray diffraction | A | UNX | — |
| 6CCT | Fragment of GID4 in complex with a short peptide | x-ray diffraction | A | — | 1 (best 0.41) |
| 6CCT | Fragment of GID4 in complex with a short peptide | x-ray diffraction | A | — | — |
| 6CCU | Complex between a GID4 fragment and a short peptide | x-ray diffraction | A | UNX | 1 (best 0.44) |
| 6CCU | Complex between a GID4 fragment and a short peptide | x-ray diffraction | A | UNX | — |
| 6CD8 | Complex of GID4 fragment with short peptide | x-ray diffraction | A, B | UNX | — |
| 6CD8 | Complex of GID4 fragment with short peptide | x-ray diffraction | A, B | UNX | — |
| 6CD9 | GID4 in complex with a peptide | x-ray diffraction | A | UNX | 1 (best 0.46) |
| 6CD9 | GID4 in complex with a peptide | x-ray diffraction | A | UNX | — |
| 6CDC | GID4 in complex with a tetrapeptide | x-ray diffraction | A | UNX | 1 (best 0.37) |
| 6CDC | GID4 in complex with a tetrapeptide | x-ray diffraction | A | UNX | — |
| 6CDG | GID4 fragment in complex with a peptide | x-ray diffraction | A | UNX | 1 (best 0.40) |
| 6CDG | GID4 fragment in complex with a peptide | x-ray diffraction | A | UNX | — |
| 6WZX | GID4 in complex with IGLWKS peptide | x-ray diffraction | A, B | UNX | — |
| 6WZX | GID4 in complex with iglwks peptide | x-ray diffraction | A, B | UNX | — |
| 6WZZ | GID4 in complex with VGLWKS peptide | x-ray diffraction | A | UNX | 1 (best 0.41) |
| 6WZZ | GID4 in complex with vglwks peptide | x-ray diffraction | A | UNX | — |
| 7NSC | Substrate receptor scaffolding module of human CTLH E3 ubiquitin ligase | electron microscopy | D | — | 9 (best 0.81) |
| 7NSC | Substrate receptor scaffolding module of human ctlh E3 ubiquitin ligase | electron microscopy | D | — | — |
| 7Q4Y | human Gid4 bound to a Gly/N-peptide | x-ray diffraction | A, B | — | 8 (best 0.60) |
| 7Q4Y | Human GID4 bound to a GLY/N-peptide | x-ray diffraction | A, B | — | — |
| 7Q50 | human Gid4 bound to a Phe/N-peptide | x-ray diffraction | A | — | 1 (best 0.55) |
| 7Q50 | Human GID4 bound to a PHE/N-peptide | x-ray diffraction | A | — | — |
| 7S12 | Crystal structure of GID4 in complex with UBF9092 | x-ray diffraction | A | 98C | — |
| 7SLZ | Crystal structure of GID4 in complex with BPF023596 | x-ray diffraction | A | 9QU | 2 (best 0.56) |
| 7SLZ | Crystal structure of GID4 in complex with BPF023596 | x-ray diffraction | A | 9QU | — |
| 7U3E | GID4 in complex with compound 1 | x-ray diffraction | A, B | L4O | 5 (best 0.63) |
| 7U3F | GID4 in complex with compound 4 | x-ray diffraction | A | L5L | 2 (best 0.67) |
| 7U3G | GID4 in complex with compound 67 | x-ray diffraction | A | L6F | 3 (best 0.44) |
| 7U3H | GID4 in complex with compound 7 | x-ray diffraction | A | L6O | 2 (best 0.60) |
| 7U3I | GID4 in complex with compound 16 | x-ray diffraction | A, B | L5X | 5 (best 0.64) |
| 7U3J | GID4 in complex with compound 88 | x-ray diffraction | A | L6U | 2 (best 0.69) |
| 7U3K | GID4 in complex with compound 89 | x-ray diffraction | A | L73 | 1 (best 0.54) |
| 7U3L | GID4 in complex with compound 91 | x-ray diffraction | A | L4X | 3 (best 0.50) |
| 8V1P | Crystal structure of GID4 in complex with UBF9092 | x-ray diffraction | A | 98C | 2 (best 0.54) |
| Q8IVV7 | AlphaFold monomer V2.0 prediction for glucose-induced degradation protein 4 homolog (Q8IVV7) | predicted | A | — | — |
Ligands
- UNX · Unknown atom or ion · in 16 records
- 98C · N,N~2~-bis[(4-methoxyphenyl)methyl]glycinamide · in 2 records
- 9QU · N-[(1s,4s)-4-(1H-benzimidazol-2-yl)cyclohexyl]-N~2~-[(1H-indol-2-yl)methyl]glycinamide · in 2 records
- L4O · tert-butyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate · in 1 record
- L4X · Nalpha-{(2R,4E)-2-[(N-benzylglycyl)amino]-5-phenylpent-4-enoyl}-N,4-dimethyl-L-phenylalaninamide · in 1 record
- L5L · (4R)-4-(4-methoxyphenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine · in 1 record
- L5X · 3-{[(5S)-5-methyl-4,5-dihydro-1,3-thiazol-2-yl]amino}phenol · in 1 record
- L6F · (1R)-1-phenyl-1,2,3,4-tetrahydroisoquinolin-5-amine · in 1 record
- L6O · (5R)-N-(4-fluorophenyl)-5-methyl-4,5-dihydro-1,3-thiazol-2-amine · in 1 record
- L6U · (2S)-2-{[(2S)-2-({N-[(2,4-dimethoxyphenyl)methyl]glycyl}amino)-2-(thiophen-2-yl)acetyl]amino}-N-methyl-4-phenylbutanamide · in 1 record
- L73 · N-butylglycyl-4-tert-butyl-D-phenylalanyl-3-methoxy-N-methyl-L-phenylalaninamide · in 1 record
Experiment against prediction
- 6CD8 chain B against the predicted model Q8IVV7: TM-score 0.99, RMSD 0.61 Å
- 6CD8 chain B against the predicted model Q8IVV7: TM-score 0.99, RMSD 0.61 Å
- 6CD8 chain A against the predicted model Q8IVV7: TM-score 0.99, RMSD 0.57 Å
- 6CD8 chain A against the predicted model Q8IVV7: TM-score 0.99, RMSD 0.57 Å
- 6WZX chain B against the predicted model Q8IVV7: TM-score 0.98, RMSD 0.69 Å
- 6WZX chain B against the predicted model Q8IVV7: TM-score 0.98, RMSD 0.69 Å
- 6WZX chain A against the predicted model Q8IVV7: TM-score 0.97, RMSD 0.81 Å
- 6WZX chain A against the predicted model Q8IVV7: TM-score 0.97, RMSD 0.81 Å
- 6CDC chain A against the predicted model Q8IVV7: TM-score 0.97, RMSD 0.95 Å
- 6CDC chain A against the predicted model Q8IVV7: TM-score 0.97, RMSD 0.95 Å
Elsewhere
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