MolNFT v1 · #183503 · protein
Substrate receptor scaffolding module of human ctlh E3 ubiquitin ligase
7NSC · Ran-binding protein 9: “Substrate receptor scaffolding module of human ctlh E3 ubiquitin ligase”. Electron microscopy, 17 pockets (best druggability 0.81). MolNFT v1 #183503 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7NSC
- Type
- protein
- Length
- 1,230 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ran-binding protein 9; Isoform 2 of armadillo repeat-containing protein 8…
- UniProt
- Q96S59, Q8IUR7, Q9NWU2, Q8IVV7
- Pockets
- 17 · best druggability 0.81
Structure
electron microscopy · 4 distinct chains · 49% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ran-binding protein 9 | protein | 276 | 28% helix, 26% strand | Q96S59 |
| E | Isoform 2 of armadillo repeat-containing protein 8 | protein | 615 | 68% helix, 0% strand | Q8IUR7 |
| H | Glucose-induced degradation protein 8 homolog | protein | 158 | 57% helix, 0% strand | Q9NWU2 |
| D | Glucose-induced degradation protein 4 homolog | protein | 181 | 9% helix, 34% strand | Q8IVV7 |
Pockets
17 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 855 | 0.81 | 0.84 | 78 | empty |
| 2 | 400 | 0.68 | 0.80 | 49 | empty |
| 3 | 56 | 0.63 | 0.93 | 16 | empty |
| 4 | 129 | 0.58 | 0.84 | 23 | empty |
| 5 | 114 | 0.50 | 0.81 | 24 | empty |
Interfaces
5 interfaces between chains.
- A–H · 2010 Ų buried · 8 hydrogen bonds · protein-protein
- E–D · 1987 Ų buried · 27 hydrogen bonds · protein-protein
- A–E · 663 Ų buried · 3 hydrogen bonds · protein-protein
- E–H · 660 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 405 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 7NSC · Substrate receptor scaffolding module of human CTLH E3 ubiquitin ligase · the same entry in another collection · chain D against D, TM-score 1.00
- Q96S59 · AlphaFold monomer V2.0 prediction for ran-binding protein 9 (Q96S59) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q9NWU2 · AlphaFold monomer V2.0 prediction for glucose-induced degradation protein 8 homolog… · a predicted model of the same protein · chain H against A, TM-score 0.92
- Q8IVV7 · AlphaFold monomer V2.0 prediction for glucose-induced degradation protein 4 homolog… · a predicted model of the same protein · chain D against A, TM-score 0.89
- Q8IUR7 · AlphaFold monomer V2.0 prediction for armadillo repeat-containing protein 8 (Q8IUR7) · a predicted model of the same protein · chain E against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96S59
- Every structure of UniProt Q8IUR7
- Every structure of UniProt Q9NWU2
- Every structure of UniProt Q8IVV7
- Elsewhere: RCSB PDB 7NSC · PDBe 7NSC · UniProt Q96S59 · UniProt Q8IUR7 · UniProt Q9NWU2 · UniProt Q8IVV7
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