UniProt Q8I6V3
Plasmepsin II (Q8I6V3)
Plasmepsin II (UniProt Q8I6V3), EC 3.4.23.39: 13 experimental structures on GenesisL1, 11 ligands bound, 30 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q8I6V3
- Protein
- Plasmepsin II
- EC
- 3.4.23.39
- Experimental structures
- 13
- Predicted models
- 0
- Ligands
- 11
- Pockets
- 30 · 7 records with a druggable one
Structures
13 records of Q8I6V3 in the MolNFT archive: 13 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5YIA | Crystal Structure of KNI-10343 bound Plasmepsin II (PMII) from Plasmodium falciparum | x-ray diffraction | A | 8V9, CPS, PO4 | 2 (best 0.64) |
| 5YIA | Crystal structure of kni-10343 bound plasmepsin II (pmii) from plasmodium falciparum | x-ray diffraction | A | 8V9, CPS, PO4 | — |
| 5YIB | Crystal Structure of KNI-10743 bound Plasmepsin II (PMII) from Plasmodium falciparum | x-ray diffraction | A | 8VC, CPS | — |
| 5YIB | Crystal structure of kni-10743 bound plasmepsin II (pmii) from plasmodium falciparum | x-ray diffraction | A | 8VC, CPS | — |
| 5YIC | Crystal Structure of KNI-10333 bound Plasmepsin II (PMII) from Plasmodium falciparum | x-ray diffraction | A | 8VO, CPS | 2 (best 0.64) |
| 5YIC | Crystal structure of kni-10333 bound plasmepsin II (pmii) from plasmodium falciparum | x-ray diffraction | A | 8VO, CPS | — |
| 5YID | Crystal Structure of KNI-10395 bound Plasmepsin II (PMII) from Plasmodium falciparum | x-ray diffraction | A | K95, CPS, NA | 2 (best 0.65) |
| 5YID | Crystal structure of kni-10395 bound plasmepsin II (pmii) from plasmodium falciparum | x-ray diffraction | A | CPS, NA | — |
| 5YIE | Crystal Structure of KNI-10742 bound Plasmepsin II (PMII) from Plasmodium falciparum | x-ray diffraction | A | CPS, 8VF, NA | 2 (best 0.66) |
| 5YIE | Crystal structure of kni-10742 bound plasmepsin II (pmii) from plasmodium falciparum | x-ray diffraction | A | CPS, 8VF, NA | — |
| 7QYH | Structure of plasmepsin II in complex with 2-aminoquinazolin-4(3H)-one based open-flap inhibitor | x-ray diffraction | A, B, C, D | I0J | 15 (best 0.80) |
| 7VE0 | Crystal Structure of Ritonavir bound Plasmepsin II (PMII) from Plasmodium falciparum | x-ray diffraction | A, B | RIT, CPS | 4 (best 0.64) |
| 7VE2 | Crystal Structure of Lopinavir bound Plasmepsin II (PMII) from Plasmodium falciparum | x-ray diffraction | A | AB1, CPS | 3 (best 0.73) |
Ligands
- CPS · 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate · in 12 records
- NA · Sodium ion · in 4 records
- 8V9 · (4R)-3-[(2S,3S)-3-[[(2R)-2-[2-(4-hydroxyphenyl) ethanoylamino]-3-methylsulfanyl-propanoyl]amino]-2-oxidanyl-4-phenyl-butanoyl]-5,5-dimethyl-N-[(1S,2R)-2-oxidanyl-2,3-dihydro-1H-inden-1-yl]-1,3-thiazolidine-4-carboxamide · in 2 records
- 8VC · (4R)-3-[(2S,3S)-3-[2-[4-[2-(dimethylamino)ethyl-methyl-amino]-2,6-dimethyl-phenoxy]ethanoylamino]-2-oxidanyl-4-phenyl-butanoyl]-5,5-dimethyl-N-[(1S,2R)-2-oxidanyl-2,3-dihydro-1H-inden-1-yl]-1,3-thiazolidine-4-carboxamide · in 2 records
- 8VF · (4R)-3-[(2S,3S)-3-[2-[4-[2-azanylethyl(ethyl)amino]-2, 6-dimethyl-phenoxy]ethanoylamino]-2-oxidanyl-4-phenyl-butanoyl]-5,5-dimethyl-N-[(1S,2R)-2-oxidanyl-2,3-dihydro-1H-inden-1-yl]-1,3-thiazolidine-4-carboxamide · in 2 records
- 8VO · (4R)-3-[(2S,3S)-3-[[(2R)-2-[2-(4-aminophenyl) ethanoylamino]-3-methylsulfanyl-propanoyl]amino]-2-oxidanyl-4-phenyl-butanoyl]-5,5-dimethyl-N-[(1S,2R)-2-oxidanyl-2,3-dihydro-1H-inden-1-yl]-1,3-thiazolidine-4-carboxamide · in 2 records
- PO4 · Phosphate ion · in 2 records
- AB1 · N-{1-benzyl-4-[2-(2,6-dimethyl-phenoxy)-acetylamino]-3-hydroxy-5-phenyl-pentyl}-3-methyl-2-(2-oxo-tetrahydro-pyrimidin-1-yl)-butyramide · in 1 record
- I0J · 2-azanyl-3-[[(2~{R})-oxolan-2-yl]methyl]-7-(5-phenylpentyl)quinazolin-4-one · in 1 record
- K95 · (4R)-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-[(2S,3S)-2-hydroxy-3-{[S-methyl-N-(phenylacetyl)-L-cysteinyl]ami no}-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide · in 1 record
- RIT · Ritonavir · in 1 record
Elsewhere
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