UniProt Q8I4X0
Actin-1 (Q8I4X0)
Actin-1 (UniProt Q8I4X0), EC 3.6.4.-: 26 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 99 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8I4X0
- Protein
- Actin-1
- EC
- 3.6.4.-
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 99 · 14 records with a druggable one
Structures
27 records of Q8I4X0 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4CBU | Crystal structure of Plasmodium falciparum actin I | x-ray diffraction | A | ATP, CA | 5 (best 0.76) |
| 5MVV | Crystal structure of Plasmodium falciparum actin I- gelsolin segment 1 -CdATP complex | x-ray diffraction | A | ATP, SCN, CD, CA | 4 (best 0.73) |
| 5MVV | Crystal structure of plasmodium falciparum actin I- gelsolin segment 1 -cdatp complex | x-ray diffraction | A | ATP, SCN, CD, CA | — |
| 6I4D | Crystal Structure of Plasmodium falciparum actin I in the Mg-K-ATP/ADP state | x-ray diffraction | A | ATP, ADP, MG, K, SCN, CL | 6 (best 0.73) |
| 6I4D | Crystal structure of plasmodium falciparum actin I in the mg-K-ATP/ADP state | x-ray diffraction | A | ATP, ADP, K, SCN, CL, CA | — |
| 6I4E | Crystal Structure of Plasmodium falciparum actin I in the Mg-ADP state | x-ray diffraction | A | ADP, MG, CA, SCN | 6 (best 0.73) |
| 6I4E | Crystal structure of plasmodium falciparum actin I in the mg-ADP state | x-ray diffraction | A | ADP, CA, SCN | — |
| 6I4F | Crystal Structure of Plasmodium falciparum actin I (A272W mutant) in the Mg-K-ATP/ADP state | x-ray diffraction | A | ATP, ADP, MG, K, NA, CL | 4 (best 0.73) |
| 6I4F | Crystal structure of plasmodium falciparum actin I (A272W mutant) in the mg-K-ATP/ADP state | x-ray diffraction | A | ATP, ADP, K, NA, CL, CA | — |
| 6I4G | Crystal Structure of Plasmodium falciparum actin I (H74Q) in the Mg-K-ATP state | x-ray diffraction | A, B | ATP, MG, K, CA | 8 (best 0.78) |
| 6I4G | Crystal structure of plasmodium falciparum actin I (H74Q) in the mg-K- ATP state | x-ray diffraction | A, B | ATP, K, CA | — |
| 6I4H | Crystal Structure of Plasmodium falciparum actin I (F54Y mutant) in the Ca-ATP state | x-ray diffraction | A | ATP, CA, CL | 4 (best 0.74) |
| 6I4H | Crystal structure of plasmodium falciparum actin I (F54Y mutant) in the ca-ATP state | x-ray diffraction | A | ATP, CL, CA | — |
| 6I4I | Crystal Structure of Plasmodium falciparum actin I (F54Y mutant) in the Mg-K-ADP-AlFn state | x-ray diffraction | A | ADP, AF3, MG, K, SCN, CA | 5 (best 0.74) |
| 6I4I | Crystal structure of plasmodium falciparum actin I (F54Y mutant) in the mg-K-ADP-alfn state | x-ray diffraction | A | ADP, AF3, K, SCN, CA | — |
| 6I4J | Crystal Structure of Plasmodium falciparum actin I (F54Y mutant) in the Mg-ADP state | x-ray diffraction | A | ADP, MG, SCN, K, CA | 5 (best 0.74) |
| 6I4J | Crystal structure of plasmodium falciparum actin I (F54Y mutant) in the mg-ADP state | x-ray diffraction | A | ADP, SCN, K, CA | — |
| 6I4K | Crystal Structure of Plasmodium falciparum actin I (G115A mutant) in the Ca-ATP state | x-ray diffraction | A | ATP, CA, SCN, CL | 5 (best 0.74) |
| 6I4K | Crystal structure of plasmodium falciparum actin I (G115A mutant) in the ca-ATP state | x-ray diffraction | A | ATP, SCN, CL, CA | — |
| 6I4L | Crystal Structure of Plasmodium falciparum actin I (G115A mutant) in the Mg-K-ATP/ADP state | x-ray diffraction | A | ATP, ADP, MG, SCN, CA | 4 (best 0.74) |
| 6I4L | Crystal structure of plasmodium falciparum actin I (G115A mutant) in the mg-K-ATP/ADP state | x-ray diffraction | A | ATP, ADP, SCN, CA | — |
| 6TU4 | Structure of Plasmodium Actin1 filament | electron microscopy | A, B, C, D, F | MG, 9UE, ADP | 18 (best 0.77) |
| 6TU4 | Structure of plasmodium ACTIN1 filament | electron microscopy | A, B, C, D, F | 9UE, ADP | — |
| 6TU7 | Structure of PfMyoA decorated Plasmodium Act1 filament | electron microscopy | BP1, CP1, DP1, EP1 | ADP, MG, 9UE | 10 (best 0.81) |
| 7ALN | Cryo-EM structure of the divergent actomyosin complex from Plasmodium falciparum Myosin A in the… | electron microscopy | A, B, C, D, E | ADP, MG, 9UE | 15 (best 0.81) |
| 7ALN | Cryo-EM structure of the divergent actomyosin complex from plasmodium falciparum myosin a in the… | electron microscopy | A, B, C, D, E | ADP, MG, 9UE | — |
| Q8I4X0 | AlphaFold monomer V2.0 prediction for actin-1 (Q8I4X0) | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 21 records
- ADP · Adenosine-5'-diphosphate · in 17 records
- ATP · Adenosine-5'-triphosphate · in 15 records
- SCN · Thiocyanate ion · in 14 records
- MG · Magnesium ion · in 11 records
- K · Potassium ion · in 10 records
- CL · Chloride ion · in 8 records
- 9UE · Jasplakinolide · in 5 records
- AF3 · Aluminum fluoride · in 2 records
- CD · Cadmium ion · in 2 records
- NA · Sodium ion · in 2 records
Experiment against prediction
- 6I4G chain B against the predicted model Q8I4X0: TM-score 0.99, RMSD 0.72 Å
- 6I4G chain B against the predicted model Q8I4X0: TM-score 0.99, RMSD 0.72 Å
- 6I4G chain A against the predicted model Q8I4X0: TM-score 0.99, RMSD 0.80 Å
- 6I4G chain A against the predicted model Q8I4X0: TM-score 0.99, RMSD 0.80 Å
- 6I4L chain A against the predicted model Q8I4X0: TM-score 0.99, RMSD 0.81 Å
- 6I4L chain A against the predicted model Q8I4X0: TM-score 0.99, RMSD 0.81 Å
- 5MVV chain A against the predicted model Q8I4X0: TM-score 0.99, RMSD 0.84 Å
- 5MVV chain A against the predicted model Q8I4X0: TM-score 0.99, RMSD 0.84 Å
- 6I4D chain A against the predicted model Q8I4X0: TM-score 0.99, RMSD 0.84 Å
- 6I4D chain A against the predicted model Q8I4X0: TM-score 0.99, RMSD 0.84 Å
Elsewhere
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