UniProt Q8CHT0
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (Q8CHT0)
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (UniProt Q8CHT0), EC 1.2.1.88: 22 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 22 pockets. Binding sites, druggability and experiment…
- UniProt
- Q8CHT0
- Protein
- Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
- EC
- 1.2.1.88
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 22 · 2 records with a druggable one
Structures
23 records of Q8CHT0 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3V9J | Crystal structure of mouse 1-pyrroline-5-carboxylate dehydrogenase complexed with sulfate ion | x-ray diffraction | A, B | — | — |
| 3V9J | Crystal structure of mouse 1-pyrroline-5-carboxylate dehydrogenase complexed with sulfate ion | x-ray diffraction | A, B | — | — |
| 3V9K | Crystal structure of mouse 1-pyrroline-5-carboxylate dehydrogenase complexed with the product… | x-ray diffraction | A, B | — | — |
| 3V9K | Crystal structure of mouse 1-pyrroline-5-carboxylate dehydrogenase complexed with the product… | x-ray diffraction | A, B | — | — |
| 3V9L | Crystal structure of mouse 1-pyrroline-5-carboxylate dehydrogenase complexed with NAD+ | x-ray diffraction | A, B | — | — |
| 3V9L | Crystal structure of mouse 1-pyrroline-5-carboxylate dehydrogenase complexed with NAD+ | x-ray diffraction | A, B | — | — |
| 4E3X | Crystal Structure of Mus musculus 1-pyrroline-5-carboxylate dehydrogenase cryoprotected in proline | x-ray diffraction | A, B | — | — |
| 4E3X | Crystal structure of mus musculus 1-pyrroline-5-carboxylate dehydrogenase cryoprotected in proline | x-ray diffraction | A, B | — | — |
| 4LGZ | Structure of mouse 1-Pyrroline-5-Carboxylate Dehydrogenase (ALDH4A1) complexed with acetate | x-ray diffraction | A, B | — | — |
| 4LGZ | Structure of mouse 1-pyrroline-5-carboxylate dehydrogenase (ALDH4A1) complexed with acetate | x-ray diffraction | A, B | — | — |
| 4LH0 | Structure of mouse 1-Pyrroline-5-Carboxylate Dehydrogenase (ALDH4A1) complexed with glyoxylate | x-ray diffraction | A, B | — | — |
| 4LH0 | Structure of mouse 1-pyrroline-5-carboxylate dehydrogenase (ALDH4A1) complexed with glyoxylate | x-ray diffraction | A, B | — | — |
| 4LH1 | Structure of mouse 1-Pyrroline-5-Carboxylate Dehydrogenase (ALDH4A1) complexed with malonate | x-ray diffraction | A, B | — | — |
| 4LH1 | Structure of mouse 1-pyrroline-5-carboxylate dehydrogenase (ALDH4A1) complexed with malonate | x-ray diffraction | A, B | — | — |
| 4LH2 | Structure of mouse 1-Pyrroline-5-Carboxylate Dehydrogenase (ALDH4A1) complexed with succinate | x-ray diffraction | A, B | — | — |
| 4LH2 | Structure of mouse 1-pyrroline-5-carboxylate dehydrogenase (ALDH4A1) complexed with succinate | x-ray diffraction | A, B | — | — |
| 4LH3 | Structure of mouse 1-Pyrroline-5-Carboxylate Dehydrogenase (ALDH4A1) complexed with glutarate | x-ray diffraction | A, B | — | — |
| 4LH3 | Structure of mouse 1-pyrroline-5-carboxylate dehydrogenase (ALDH4A1) complexed with glutarate | x-ray diffraction | A, B | — | — |
| 7MER | Structure of ALDH4A1 complexed with trans-4-Hydroxy-L-proline | x-ray diffraction | A, B | HYP, SO4 | 10 (best 0.80) |
| 7MER | Structure of ALDH4A1 complexed with trans-4-hydroxy-L-proline | x-ray diffraction | A, B | SO4 | — |
| 7MES | Structure of ALDH4A1 complexed with trans-4-Hydroxy-D-proline | x-ray diffraction | A, B | NAD, UY7 | 12 (best 0.76) |
| 7MES | Structure of ALDH4A1 complexed with trans-4-hydroxy-D-proline | x-ray diffraction | A, B | NAD | — |
| Q8CHT0 | AlphaFold monomer V2.0 prediction for delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial… | predicted | A | — | — |
Ligands
Experiment against prediction
- 7MES chain A against the predicted model Q8CHT0: TM-score 1.00, RMSD 0.22 Å
- 7MER chain B against the predicted model Q8CHT0: TM-score 1.00, RMSD 0.23 Å
- 7MER chain A against the predicted model Q8CHT0: TM-score 1.00, RMSD 0.23 Å
- 7MES chain B against the predicted model Q8CHT0: TM-score 1.00, RMSD 0.24 Å
- 4LGZ chain A against the predicted model Q8CHT0: TM-score 1.00, RMSD 0.26 Å
- 4LGZ chain A against the predicted model Q8CHT0: TM-score 1.00, RMSD 0.26 Å
- 4LH1 chain A against the predicted model Q8CHT0: TM-score 1.00, RMSD 0.27 Å
- 4LH1 chain A against the predicted model Q8CHT0: TM-score 1.00, RMSD 0.27 Å
- 4LH3 chain A against the predicted model Q8CHT0: TM-score 1.00, RMSD 0.27 Å
- 4LH3 chain A against the predicted model Q8CHT0: TM-score 1.00, RMSD 0.27 Å
Elsewhere
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