UniProt Q8C7D2
Protein cereblon (Q8C7D2)
Protein cereblon (UniProt Q8C7D2): 14 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8C7D2
- Protein
- Protein cereblon
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 7 · 1 record with a druggable one
Structures
15 records of Q8C7D2 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3WX1 | Mouse Cereblon thalidomide binding domain, selenomethionine derivative | x-ray diffraction | A, B | — | — |
| 3WX1 | Mouse cereblon thalidomide binding domain, selenomethionine derivative | x-ray diffraction | A, B | — | — |
| 3WX2 | Mouse Cereblon thalidomide binding domain, native | x-ray diffraction | A, B | — | — |
| 3WX2 | Mouse cereblon thalidomide binding domain, native | x-ray diffraction | A, B | — | — |
| 4TZC | Crystal Structure of Murine Cereblon in Complex with Thalidomide | x-ray diffraction | C, A, B, D | — | — |
| 4TZC | Crystal structure of murine cereblon in complex with thalidomide | x-ray diffraction | C, A, B, D | — | — |
| 4TZU | Crystal Structure of Murine Cereblon in Complex with Pomalidomide | x-ray diffraction | A, B, C, D | — | — |
| 4TZU | Crystal structure of murine cereblon in complex with pomalidomide | x-ray diffraction | A, B, C, D | — | — |
| 5YIZ | Mouse Cereblon thalidomide binding domain complexed with racemic thalidomide | x-ray diffraction | A, D, G, J, M, P, S, V, Y, b, e, h, k, n, q, t | EF2, ZN, SO4 | — |
| 5YIZ | Mouse cereblon thalidomide binding domain complexed with racemic thalidomide | x-ray diffraction | A, D, G, J, M, P, S, V, Y, b, e, h, k, n, q, t | EF2, ZN, SO4 | — |
| 5YJ0 | Mouse Cereblon thalidomide binding domain complexed with S-form thalidomide | x-ray diffraction | A, D, G, J, M, P, S, V, Y, b, e, h, k, n, q, t | EF2, ZN, SO4 | — |
| 5YJ0 | Mouse cereblon thalidomide binding domain complexed with S-form thalidomide | x-ray diffraction | A, D, G, J, M, P, S, V, Y, b, e, h, k, n, q, t | EF2, ZN, SO4 | — |
| 5YJ1 | Mouse Cereblon thalidomide binding domain complexed with R-form thalidomide | x-ray diffraction | A, D, G, J, M, P, S, V, Y, b, e, h, k, n, q, t | 6EL, ZN, SO4 | 7 (best 0.75) |
| 5YJ1 | Mouse cereblon thalidomide binding domain complexed with R-form thalidomide | x-ray diffraction | A, D, G, J, M, P, S, V, Y, b, e, h, k, n, q, t | ZN, SO4 | — |
| Q8C7D2 | AlphaFold monomer V2.0 prediction for protein cereblon (Q8C7D2) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4TZU chain D against the predicted model Q8C7D2: TM-score 0.98, RMSD 0.51 Å
- 4TZU chain D against the predicted model Q8C7D2: TM-score 0.98, RMSD 0.51 Å
- 4TZU chain A against the predicted model Q8C7D2: TM-score 0.98, RMSD 0.52 Å
- 4TZU chain A against the predicted model Q8C7D2: TM-score 0.98, RMSD 0.52 Å
- 4TZU chain C against the predicted model Q8C7D2: TM-score 0.97, RMSD 0.60 Å
- 4TZU chain C against the predicted model Q8C7D2: TM-score 0.97, RMSD 0.60 Å
- 4TZU chain B against the predicted model Q8C7D2: TM-score 0.97, RMSD 1.00 Å
- 4TZU chain B against the predicted model Q8C7D2: TM-score 0.97, RMSD 1.00 Å
- 5YJ0 chain n against the predicted model Q8C7D2: TM-score 0.97, RMSD 0.74 Å
- 5YJ0 chain n against the predicted model Q8C7D2: TM-score 0.97, RMSD 0.74 Å
Elsewhere
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