UniProt Q8BHN3
Neutral alpha-glucosidase AB (Q8BHN3)
Neutral alpha-glucosidase AB (UniProt Q8BHN3), EC 3.2.1.207, 3.2.1.84: 24 experimental structures and 1 predicted model on GenesisL1, 16 ligands bound, 173 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q8BHN3
- Protein
- Neutral alpha-glucosidase AB
- EC
- 3.2.1.207, 3.2.1.84
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 16
- Pockets
- 173 · 11 records with a druggable one
Structures
25 records of Q8BHN3 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5F0E | Murine endoplasmic reticulum alpha-glucosidase II | x-ray diffraction | A | NAG, CA | 7 (best 0.59) |
| 5F0E | Murine endoplasmic reticulum alpha-glucosidase II | x-ray diffraction | A | — | — |
| 5H9O | Complex of Murine endoplasmic reticulum alpha-glucosidase II with D-Glucose | x-ray diffraction | A, C | NAG, OXM, GLC, CA | 20 (best 0.71) |
| 5H9O | Complex of murine endoplasmic reticulum alpha-glucosidase II with D- glucose | x-ray diffraction | A, C | — | — |
| 5HJO | Murine endoplasmic reticulum alpha-glucosidase II with bound substrate analogue | x-ray diffraction | A, C | NAG, MAN, DGO, Z61, CA | 20 (best 0.68) |
| 5HJO | Murine endoplasmic reticulum alpha-glucosidase II with bound substrate analogue | x-ray diffraction | A, C | — | — |
| 5HJR | Murine endoplasmic reticulum alpha-glucosidase II with bound covalent intermediate | x-ray diffraction | A, C | NAG, MAN, 5GF, OXM, CA | 18 (best 0.68) |
| 5HJR | Murine endoplasmic reticulum alpha-glucosidase II with bound covalent intermediate | x-ray diffraction | A, C | — | — |
| 5IED | Murine endoplasmic reticulum alpha-glucosidase II with castanospermine | x-ray diffraction | A | NAG, CTS | — |
| 5IED | Murine endoplasmic reticulum alpha-glucosidase II with castanospermine | x-ray diffraction | A | — | — |
| 5IEE | Murine endoplasmic reticulum alpha-glucosidase II with 1-deoxynojirimycin | x-ray diffraction | A | NAG, NOJ, CA | 8 (best 0.59) |
| 5IEE | Murine endoplasmic reticulum alpha-glucosidase II with 1- deoxynojirimycin | x-ray diffraction | A | — | — |
| 5IEF | Murine endoplasmic reticulum alpha-glucosidase II with N-butyl-1-deoxynojirimycin | x-ray diffraction | A | NAG, NBV, CA | 10 (best 0.59) |
| 5IEF | Murine endoplasmic reticulum alpha-glucosidase II with N-butyl-1- deoxynojirimycin | x-ray diffraction | A | — | — |
| 5IEG | Murine endoplasmic reticulum alpha-glucosidase II with N-9'-methoxynonyl-1-deoxynojirimycin. | x-ray diffraction | A | NAG, 6A9, CA | 10 (best 0.66) |
| 5IEG | Murine endoplasmic reticulum alpha-glucosidase II with N-9'- methoxynonyl-1-deoxynojirimycin | x-ray diffraction | A | — | — |
| 7KBJ | Co-crystal structure of alpha glucosidase with compound 9 | x-ray diffraction | G, H, A, I, J, C | SO4, WAV, CA | 20 (best 0.72) |
| 7KBJ | Co-crystal structure of alpha glucosidase with compound 9 | x-ray diffraction | G, H, A, I, J, C | SO4, WAV | — |
| 7KBR | Co-crystal structure of alpha glucosidase with compound 10 | x-ray diffraction | G, H, A, I, J, C | SO4, WAS, CA | 20 (best 0.68) |
| 7KBR | Co-crystal structure of alpha glucosidase with compound 10 | x-ray diffraction | G, H, A, I, J, C | SO4, WAS | — |
| 7KRY | Co-crystal structure of alpha glucosidase with compound 11 | x-ray diffraction | A, C | X8Y, SO4, CA | 20 (best 0.71) |
| 7KRY | Co-crystal structure of alpha glucosidase with compound 11 | x-ray diffraction | A, C | X8Y, SO4, CA | — |
| 7L9E | Crystal structure of apo-alpha glucosidase | x-ray diffraction | E, F, A, G, H, C | SO4, CA | 20 (best 0.69) |
| 7L9E | Crystal structure of apo-alpha glucosidase | x-ray diffraction | E, F, A, G, H, C | SO4 | — |
| Q8BHN3 | AlphaFold monomer V2.0 prediction for neutral alpha-glucosidase ab (Q8BHN3) | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 12 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 8 records
- SO4 · Sulfate ion · in 8 records
- MAN · alpha-D-mannopyranose · in 2 records
- OXM · Oxamic acid · in 2 records
- WAS · 2-{[2-nitro-4-(triazan-1-yl)phenyl]amino}ethyl (2-{[(1S,2S,3R,4S,5S)-2,3,4,5-tetrahydroxy-5-(hydroxymethyl)cyclohexyl]amino}ethyl)carbamate · in 2 records
- WAV · (1S,2S,3R,4S,5S)-1-(hydroxymethyl)-5-{[2-(2-{[2-nitro-4-(triazan-1-yl)phenyl]amino}ethoxy) ethyl]amino}cyclohexane-1,2,3,4-tetrol · in 2 records
- X8Y · (1S,2S,3R,4S,5S)-5-({6-[(4-azido-2-nitrophenyl) amino]hexyl}amino)-1-(hydroxymethyl)cyclohexane-1,2,3, 4-tetrol · in 2 records
- 5GF · 5-fluoro-beta-D-glucopyranose · in 1 record
- 6A9 · N-9'-methoxynonyl-1-deoxynojirimycin · in 1 record
- CTS · Castanospermine · in 1 record
- DGO · D-glucal · in 1 record
- GLC · alpha-D-glucopyranose · in 1 record
- NBV · (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol · in 1 record
- NOJ · 1-deoxynojirimycin · in 1 record
- Z61 · 2-deoxy-alpha-D-arabino-hexopyranose · in 1 record
Experiment against prediction
- 5HJO chain A against the predicted model Q8BHN3: TM-score 1.00, RMSD 0.20 Å
- 5HJO chain A against the predicted model Q8BHN3: TM-score 1.00, RMSD 0.20 Å
- 5H9O chain A against the predicted model Q8BHN3: TM-score 1.00, RMSD 0.21 Å
- 5H9O chain A against the predicted model Q8BHN3: TM-score 1.00, RMSD 0.21 Å
- 5HJO chain C against the predicted model Q8BHN3: TM-score 1.00, RMSD 0.22 Å
- 5HJO chain C against the predicted model Q8BHN3: TM-score 1.00, RMSD 0.22 Å
- 5IEE chain A against the predicted model Q8BHN3: TM-score 1.00, RMSD 0.23 Å
- 5IEE chain A against the predicted model Q8BHN3: TM-score 1.00, RMSD 0.23 Å
- 5H9O chain C against the predicted model Q8BHN3: TM-score 1.00, RMSD 0.23 Å
- 5H9O chain C against the predicted model Q8BHN3: TM-score 1.00, RMSD 0.23 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.