UniProt Q86UY6
N-alpha-acetyltransferase 40 (Q86UY6)
N-alpha-acetyltransferase 40 (UniProt Q86UY6), EC 2.3.1.-, 2.3.1.257: 8 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 36 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q86UY6
- Protein
- N-alpha-acetyltransferase 40
- EC
- 2.3.1.-, 2.3.1.257
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 36 · 7 records with a druggable one
Structures
9 records of Q86UY6 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4U9V | Crystal structure of NatD (Naa40p) bound to acetyl CoA | x-ray diffraction | B | ACO | 1 (best 0.67) |
| 4U9V | Crystal structure of natd (NAA40P) bound to acetyl CoA | x-ray diffraction | B | ACO | 1 (best 0.67) |
| 4U9W | Crystal Structure of NatD bound to H4/H2A peptide and CoA | x-ray diffraction | A, B, C, D | COA, NA | 12 (best 0.62) |
| 4U9W | Crystal structure of natd bound to H4/H2A peptide and CoA | x-ray diffraction | A, B, C, D | NH2, COA, NA | 12 (best 0.62) |
| 7KD7 | Crystal structure of human NatD (NAA40) bound to a bisubstrate analogue | x-ray diffraction | D, A | SO4, CMC, NH2 | 4 (best 0.73) |
| 7KD7 | Crystal structure of human natd (NAA40) bound to a bisubstrate analogue | x-ray diffraction | D, A | SO4, CMC, NH2 | — |
| 7KPU | Crystal structure of human NatD (NAA40) bound to a bisubstrate analogue with a C-3 linker | x-ray diffraction | D, A | SO4, WZG, NH2, ACE | 4 (best 0.73) |
| 7KPU | Crystal structure of human natd (NAA40) bound to a bisubstrate analogue with a C-3 linker | x-ray diffraction | D, A | SO4, WZG, NH2, ACE | — |
| Q86UY6 | AlphaFold monomer V2.0 prediction for N-alpha-acetyltransferase 40 (Q86UY6) | predicted | A | — | 2 (best 0.65) |
Ligands
- NH2 · Amino group · in 5 records
- SO4 · Sulfate ion · in 4 records
- ACE · Acetyl group · in 2 records
- ACO · Acetyl coenzyme *A · in 2 records
- CMC · Carboxymethyl coenzyme *A · in 2 records
- COA · Coenzyme A · in 2 records
- NA · Sodium ion · in 2 records
- WZG · [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R)-3-hydroxy-2,2-dimethyl-4-[(3-{[2-(methylsulfanyl) ethyl]amino}-3-oxopropyl)amino]-4-oxobutyl dihydrogen diphosphate (non-preferred name) · in 2 records
Experiment against prediction
- 7KPU chain A against the predicted model Q86UY6: TM-score 0.99, RMSD 0.45 Å
- 7KPU chain A against the predicted model Q86UY6: TM-score 0.99, RMSD 0.45 Å
- 4U9W chain D against the predicted model Q86UY6: TM-score 0.99, RMSD 0.53 Å
- 4U9W chain D against the predicted model Q86UY6: TM-score 0.99, RMSD 0.53 Å
- 7KPU chain D against the predicted model Q86UY6: TM-score 0.99, RMSD 0.52 Å
- 7KPU chain D against the predicted model Q86UY6: TM-score 0.99, RMSD 0.52 Å
- 4U9W chain C against the predicted model Q86UY6: TM-score 0.99, RMSD 0.55 Å
- 4U9W chain C against the predicted model Q86UY6: TM-score 0.99, RMSD 0.55 Å
- 4U9W chain B against the predicted model Q86UY6: TM-score 0.99, RMSD 0.78 Å
- 4U9W chain B against the predicted model Q86UY6: TM-score 0.99, RMSD 0.78 Å
Elsewhere
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