UniProt Q834R3
Thymidylate synthase (Q834R3)
Thymidylate synthase (UniProt Q834R3), EC 2.1.1.45: 11 experimental structures on GenesisL1, 6 ligands bound, 31 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q834R3
- Protein
- Thymidylate synthase
- EC
- 2.1.1.45
- Experimental structures
- 11
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 31 · 2 records with a druggable one
Structures
11 records of Q834R3 in the MolNFT archive: 11 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3UWL | Crystal structure of Enteroccocus faecalis thymidylate synthase (EfTS) in complex with 5-formyl… | x-ray diffraction | A, B, C, D | — | — |
| 3UWL | Crystal structure of enteroccocus faecalis thymidylate synthase (efts) in complex with 5-formyl… | x-ray diffraction | A, B, C, D | — | — |
| 4O7U | Etherocomplex of Enteroccocus faecalis thymidylate synthase with 5-hydroxymethilene-6-hydrofolic… | x-ray diffraction | A, B, C, D | — | — |
| 4O7U | Etherocomplex of enteroccocus faecalis thymidylate synthase with 5- hydroxymethilene-6-hydrofolic… | x-ray diffraction | A, B, C, D | — | — |
| 5J7W | Enterococcus faecalis thymidylate synthase complex with methotrexate | x-ray diffraction | A, B, C, D | SO4, MTX | 17 (best 0.76) |
| 5J7W | Enterococcus faecalis thymidylate synthase complex with methotrexate | x-ray diffraction | A, B, C, D | — | — |
| 6QXS | Crystal structure of Enteroccocus faecalis thymidylate synthase (EfTS) in complex with FdUMP | x-ray diffraction | A, B, C, D | UFP, SO4 | — |
| 6QXS | Crystal structure of enteroccocus faecalis thymidylate synthase (efts) in complex with fdump | x-ray diffraction | A, B, C, D | UFP, SO4 | — |
| 6QYA | Crystal structure of Enteroccocus faecalis thymidylate synthase (EfTS) in complex with dUMP | x-ray diffraction | A, B, C, D | UMP, FFO, SO4, CL | 14 (best 0.72) |
| 6QYA | Crystal structure of enteroccocus faecalis thymidylate synthase (efts) in complex with dump | x-ray diffraction | A, B, C, D | UMP, SO4, CL | — |
| Q834R3 | AlphaFold monomer V2.0 prediction for thymidylate synthase (Q834R3) | — | — | — |
Ligands
- SO4 · Sulfate ion · in 5 records
- CL · Chloride ion · in 2 records
- UFP · 5-fluoro-2'-deoxyuridine-5'-monophosphate · in 2 records
- UMP · 2'-deoxyuridine 5'-monophosphate · in 2 records
- FFO · N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid · in 1 record
- MTX · Methotrexate · in 1 record
Elsewhere
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