GL1X · GenesisL1 explorer

Ligand · THF

THF · 5-hydroxymethylene-6-hydrofolic acid

THF, 5-hydroxymethylene-6-hydrofolic acid (C20 H23 N7 O7, 473.4 g/mol), in the MolNFT structures on GenesisL1: bound in 10 records (5 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the…

Component
THF
Formula
C20 H23 N7 O7
Class
ligand
Structures
10
PDB entries
5

Binding sites

THF in 10 structures; the first of them:

  • 1EJI · Recombinant serine hydroxymethyltransferase (mouse) · THF A600 · binds LEU143, GLY146, GLY147, HIS148, LEU149, PHE153, LYS158, ILE160 and 12 more
  • 1U3G · Structural and Functional Characterization of a 5,10-Methenyltetrahydrofolate Synthetase… · THF A501 · binds TYR49, GLU50, PRO51, ILE52, GLU55, PRO76, VAL78, PRO105 and 5 more
  • 2TDD · Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in… · THF A568 · binds PRO53, ILE81, TRP82, GLU84, TRP85, GLU88, LEU195, LEU224 and 3 more
  • 3SUX · Crystal structure of THF riboswitch, bound with THF · THF X103 · binds U28, G29, C58, G59, G77
  • 4O7U · Etherocomplex of Enteroccocus faecalis thymidylate synthase with… · THF B401 · binds LYS49, PRO52, LEU55, GLU59, ILE80, TRP81, TRP84, TYR145 and 10 more
  • 1EJI · Recombinant serine hydroxymethyltransferase (mouse) · THF A600 · binds LEU143, GLY146, GLY147, HIS148, LEU149, PHE153, LYS158, ILE160 and 12 more
  • 1U3G · Structural and functional characterization of a 5,10- methenyltetrahydrofolate synthetase… · THF A501 · binds TYR49, GLU50, PRO51, ILE52, GLU55, PRO76, VAL78, PRO105 and 5 more
  • 2TDD · Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in… · THF A568 · binds PRO53, ILE81, TRP82, GLU84, TRP85, GLU88, LEU195, LEU224 and 3 more
  • 3SUX · Crystal structure of thf riboswitch, bound with thf · THF X103 · binds U28, G29, C58, G59, G77
  • 4O7U · Etherocomplex of enteroccocus faecalis thymidylate synthase with 5… · THF B401 · binds LYS49, PRO52, LEU55, GLU59, ILE80, TRP81, TRP84, TYR145 and 10 more

Residues it binds most

LEU 10, TYR 10, PHE 12, GLU 12, PRO 12, ILE 12, GLY 8, ASN 8, LYS 10, ALA 8 (residue and the binding sites it lines).

Found with

  • ADP · Adenosine-5'-diphosphate
  • PLG · N-glycine-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-yl-methane]
  • SS7 · 4-{[(2S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]oxy}-3,5-dimethylphenyl acetate
  • UFP · 5-fluoro-2'-deoxyuridine-5'-monophosphate
  • MG · Magnesium ion
  • NA · Sodium ion
  • PO4 · Phosphate ion
  • SO4 · Sulfate ion
  • EDO · 1,2-ethanediol

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.