MolNFT v1 · #23548 · protein

Structural and functional characterization of a 5,10- methenyltetrahydrofolate synthetase from mycoplasma pneumoniae (gi: 13508087)

1U3G · 5,10-methenyltetrahydrofolate synthetase: “Structural and functional characterization of a 5,10- methenyltetrahydrofolate synthetase from mycoplasma…”. X-ray diffraction, 4 ligands (ADP, THF, MG), 1 pocket (best druggability 0.54).…

PDB: 1U3G
Type: protein
Length: 164 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5,10-methenyltetrahydrofolate synthetase
EC: 6.3.3.2
UniProt: P75430
Ligands: ADP, THF, MG, PO4
Pockets: 1 · best druggability 0.54

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	5,10-methenyltetrahydrofolate synthetase (EC 6.3.3.2)	protein	164	31% helix, 21% strand	P75430

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · chains A
THF · 5-hydroxymethylene-6-hydrofolic acid · ligand · chains A
MG · Magnesium ion · metal · chains A
PO4 · Phosphate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	173	0.54	0.79	25	PO4, MG, THF

Compared structures

1U3G · Structural and Functional Characterization of a 5,10-Methenyltetrahydrofolate Synthetase… · the same entry in another collection · chain A against A, TM-score 1.00
P75430 · AlphaFold monomer V2.0 prediction for 5-formyltetrahydrofolate cyclo- ligase (P75430) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P75430
Elsewhere: RCSB PDB 1U3G · PDBe 1U3G · UniProt P75430

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