UniProt Q7TNG8
Probable D-lactate dehydrogenase, mitochondrial (Q7TNG8)
Probable D-lactate dehydrogenase, mitochondrial (UniProt Q7TNG8), EC 1.1.2.4: 18 experimental structures on GenesisL1, 16 ligands bound, 86 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q7TNG8
- Protein
- Probable D-lactate dehydrogenase, mitochondrial
- EC
- 1.1.2.4
- Experimental structures
- 18
- Predicted models
- 0
- Ligands
- 16
- Pockets
- 86 · 17 records with a druggable one
Structures
18 records of Q7TNG8 in the MolNFT archive: 18 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8JDB | Crystal structure of H405A mLDHD in complex with D-2-hydroxyoctanoic acid | x-ray diffraction | A | FAD, UIT | 6 (best 0.87) |
| 8JDC | Crystal structure of mLDHD in apo form | x-ray diffraction | A | FAD | 5 (best 0.85) |
| 8JDD | Crystal structure of H405A mLDHD in apo form | x-ray diffraction | A | FAD | 4 (best 0.86) |
| 8JDE | Crystal structure of mLDHD in complex with D-lactate | x-ray diffraction | A | FAD, MN, LAC | 6 (best 0.86) |
| 8JDF | Crystal structure of H405A mLDHD in complex with D-lactate | x-ray diffraction | A | FAD, LAC | 5 (best 0.86) |
| 8JDG | Crystal structure of H405A mLDHD in complex with D-2-hydroxybutanoic acid | x-ray diffraction | A | FAD, UCU | 4 (best 0.86) |
| 8JDN | Crystal structure of H405A mLDHD in complex with D-2-hydroxyvaleric acid | x-ray diffraction | A | FAD, UE3 | 5 (best 0.86) |
| 8JDO | Crystal structure of H405A mLDHD in complex with D-2-hydroxyhexanoic acid | x-ray diffraction | A | 7N6, FAD | 4 (best 0.86) |
| 8JDP | Crystal structure of H405A mLDHD in complex with D-2-hydroxyisovaleric acid | x-ray diffraction | A | FAD, VAD | 4 (best 0.86) |
| 8JDQ | Crystal structure of H405A mLDHD in complex with D-2-hydroxyisocaproic acid | x-ray diffraction | A | FAD, 2RH | 6 (best 0.86) |
| 8JDR | Crystal structure of H405A mLDHD in complex with D-2-hydroxy-3-methyl-valeric acid | x-ray diffraction | A | FAD, UEI | 5 (best 0.86) |
| 8JDS | Crystal structure of mLDHD in complex with Pyruvate | x-ray diffraction | A | FAD, MN, PYR | 5 (best 0.86) |
| 8JDT | Crystal structure of mLDHD in complex with 2-ketobutanoic acid | x-ray diffraction | A | FAD, 2KT, MN | 6 (best 0.86) |
| 8JDU | Crystal structure of mLDHD in complex with 2-ketovaleric acid | x-ray diffraction | A | FAD, MN, 69O | 5 (best 0.86) |
| 8JDV | Crystal structure of mLDHD in complex with 2-ketohexanoic acid | x-ray diffraction | A | FAD, MN, 7N5 | 6 (best 0.86) |
| 8JDX | Crystal structure of mLDHD in complex with 2-ketoisovaleric acid | x-ray diffraction | A | FAD, MN, KIV | 4 (best 0.86) |
| 8JDZ | Crystal structure of mLDHD in complex with 2-keto-3-methylvaleric acid | x-ray diffraction | A | FAD, MN, 1QQ | 6 (best 0.86) |
| Q7TNG8 | AlphaFold monomer V2.0 prediction for probable D-lactate dehydrogenase, mitochondrial (Q7TNG8) | — | — | — |
Ligands
- FAD · Flavin-adenine dinucleotide · in 17 records
- MN · Manganese (II) ion · in 7 records
- LAC · Lactic acid · in 2 records
- 1QQ · (3S)-3-methyl-2-oxopentanoic acid · in 1 record
- 2KT · 2-ketobutyric acid · in 1 record
- 2RH · (2R)-2-hydroxy-4-methylpentanoic acid · in 1 record
- 69O · 2-oxopentanoic acid · in 1 record
- 7N5 · 2-Ketohexanoic acid · in 1 record
- 7N6 · (2R)-2-hydroxyhexanoic acid · in 1 record
- KIV · 3-methyl-2-oxobutanoic acid · in 1 record
- PYR · Pyruvic acid · in 1 record
- UCU · (2R)-2-oxidanylbutanoic acid · in 1 record
- UE3 · (2R)-2-oxidanylpentanoic acid · in 1 record
- UEI · (2R,3S)-3-methyl-2-oxidanyl-pentanoic acid · in 1 record
- UIT · (2R)-2-oxidanyloctanoic acid · in 1 record
- VAD · Deaminohydroxyvaline · in 1 record
Elsewhere
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