UniProt Q6ZMG9
Isoform 2 of Ceramide synthase 6 (Q6ZMG9)
Isoform 2 of Ceramide synthase 6 (UniProt Q6ZMG9), EC 2.3.1.291: 3 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q6ZMG9
- Protein
- Isoform 2 of Ceramide synthase 6
- EC
- 2.3.1.291
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 20 · 3 records with a druggable one
Structures
4 records of Q6ZMG9 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8QZ6 | Structure of human ceramide synthase 6 (CerS6) bound to C16:0 | electron microscopy | A, C | PLM, PC1, NAG | 9 (best 0.77) |
| 8QZ7 | Structure of human ceramide synthase 6 (CerS6) in complex with N-palmitoyl fumonisin B1 | electron microscopy | A, C | XBX, PC1, NAG | 6 (best 0.80) |
| 9EOT | Structure of human ceramide synthase 6 (CerS6) bound to C16:0 (nanobody Nb02) | electron microscopy | A, C | PLM, PC1, NAG | 5 (best 0.76) |
| Q6ZMG9 | AlphaFold monomer V2.0 prediction for ceramide synthase 6 (Q6ZMG9) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 3 records
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 3 records
- PLM · Palmitic acid · in 2 records
- XBX · (2~{R})-2-[2-[(5~{R},6~{R},7~{S},9~{S},11~{R},16~{R},18~{S},19~{S})-6-[(3~{R})-3-carboxy-5-oxidanyl-5-oxidanylidene-pentanoyl]oxy-19-(hexadecanoylamino)-5,9-dimethyl-11,16,18-tris(oxidanyl)icosan-7-yl]oxy-2-oxidanylidene-ethyl]butanedioic acid · in 1 record
Experiment against prediction
- 9EOT chain C against the predicted model Q6ZMG9: TM-score 0.88, RMSD 2.76 Å
- 9EOT chain A against the predicted model Q6ZMG9: TM-score 0.88, RMSD 2.76 Å
- 8QZ6 chain A against the predicted model Q6ZMG9: TM-score 0.87, RMSD 2.75 Å
- 8QZ6 chain C against the predicted model Q6ZMG9: TM-score 0.87, RMSD 2.75 Å
- 8QZ7 chain C against the predicted model Q6ZMG9: TM-score 0.85, RMSD 2.69 Å
- 8QZ7 chain A against the predicted model Q6ZMG9: TM-score 0.85, RMSD 2.69 Å
Elsewhere
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