UniProt Q6VAB6
Kinase suppressor of Ras 2 (Q6VAB6)
Kinase suppressor of Ras 2 (UniProt Q6VAB6), EC 2.7.11.1: 17 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 40 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q6VAB6
- Protein
- Kinase suppressor of Ras 2
- EC
- 2.7.11.1
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 40 · 9 records with a druggable one
Structures
18 records of Q6VAB6 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2Y4I | KSR2-MEK1 heterodimer | x-ray diffraction | B | — | — |
| 2Y4I | KSR2-MEK1 heterodimer | x-ray diffraction | B | — | — |
| 5KKR | KSR2:MEK1 Complex Bound to the Small Molecule APS-2-79 | x-ray diffraction | B | 6U7 | 5 (best 0.81) |
| 5KKR | KSR2:MEK1 complex bound to the small molecule aps-2-79 | x-ray diffraction | B | 6U7 | — |
| 7JUQ | Crystal Structure of KSR2:MEK1 in complex with ADP | x-ray diffraction | B | ADP, MG | 4 (best 0.82) |
| 7JUQ | Crystal structure of KSR2:MEK1 in complex with ADP | x-ray diffraction | B | ADP, MG | — |
| 7JUR | Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Trametinib | x-ray diffraction | B | ANP, MG, QOM | 4 (best 0.82) |
| 7JUR | Crystal structure of KSR2:MEK1 in complex with AMP-pnp, and allosteric MEK inhibitor trametinib | x-ray diffraction | B | ANP, MG, QOM | — |
| 7JUS | Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Cobimetinib | x-ray diffraction | B | ANP, MG | 3 (best 0.79) |
| 7JUS | Crystal structure of KSR2:MEK1 in complex with AMP-pnp, and allosteric MEK inhibitor cobimetinib | x-ray diffraction | B | ANP, MG | — |
| 7JUT | Crystal Structure of KSR2:MEK1 in complex with ANP-PNP, and allosteric MEK inhibitor Selumetinib | x-ray diffraction | B | ANP | 4 (best 0.80) |
| 7JUT | Crystal structure of KSR2:MEK1 in complex with anp-pnp, and allosteric MEK inhibitor selumetinib | x-ray diffraction | B | ANP | — |
| 7JUU | Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor PD0325901 | x-ray diffraction | B | ANP, MG | 5 (best 0.80) |
| 7JUU | Crystal structure of KSR2:MEK1 in complex with AMP-pnp, and allosteric MEK inhibitor PD0325901 | x-ray diffraction | B | ANP, MG | — |
| 7JUV | Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor APS-9-95-1 | x-ray diffraction | B | ANP, MG, VKG | 4 (best 0.82) |
| 7JUV | Crystal structure of KSR2:MEK1 in complex with AMP-pnp, and allosteric MEK inhibitor aps-9-95-1 | x-ray diffraction | B | ANP, MG, VKG | — |
| 7UMB | NanoBRET tracer Tram-bo bound to a KSR2-MEK1 complex | x-ray diffraction | B | ANP, U9F | 3 (best 0.82) |
| Q6VAB6 | AlphaFold monomer V2.0 prediction for kinase suppressor of RAS 2 (Q6VAB6) | predicted | A | — | 8 (best 0.63) |
Ligands
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 11 records
- MG · Magnesium ion · in 10 records
- 6U7 · 6,7-dimethoxy-~{N}-(2-methyl-4-phenoxy-phenyl) quinazolin-4-amine · in 2 records
- ADP · Adenosine-5'-diphosphate · in 2 records
- QOM · Trametinib · in 2 records
- VKG · N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6, 8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)-N'-methylsulfuric diamide · in 2 records
- U9F · {3-[(1M,2M)-2-{[(1S,2P)-1H,1'H-[2,2'-bipyrrol]-5-yl-kappaN~1~]methylidene}-2H-pyrrol-5-yl-kappaN]-N-(2-{2-[3-({(3M)-3-[(4aM)-3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl}amino)-3-oxopropoxy]ethoxy}ethyl)propanamidato}(difluorido)boron · in 1 record
Experiment against prediction
- 7JUR chain B against the predicted model Q6VAB6: TM-score 0.96, RMSD 1.82 Å
- 7JUR chain B against the predicted model Q6VAB6: TM-score 0.96, RMSD 1.82 Å
- 7JUS chain B against the predicted model Q6VAB6: TM-score 0.96, RMSD 1.84 Å
- 7JUS chain B against the predicted model Q6VAB6: TM-score 0.96, RMSD 1.84 Å
- 7UMB chain B against the predicted model Q6VAB6: TM-score 0.96, RMSD 1.85 Å
- 7JUV chain B against the predicted model Q6VAB6: TM-score 0.96, RMSD 1.85 Å
- 7JUV chain B against the predicted model Q6VAB6: TM-score 0.96, RMSD 1.85 Å
- 7JUT chain B against the predicted model Q6VAB6: TM-score 0.95, RMSD 1.91 Å
- 7JUT chain B against the predicted model Q6VAB6: TM-score 0.95, RMSD 1.91 Å
- 7JUU chain B against the predicted model Q6VAB6: TM-score 0.95, RMSD 1.94 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.