Ligand · QOM
QOM · Trametinib
QOM, Trametinib (C26 H23 F I N5 O4, 615.4 g/mol), in the MolNFT structures on GenesisL1: bound in 5 records (4 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.
- Component
- QOM
- Formula
- C26 H23 F I N5 O4
- Class
- ligand
- Structures
- 5
- PDB entries
- 4
Binding sites
QOM in 5 structures; the first of them:
- 7JUR · Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor… · QOM C402 · binds PRO878, LYS97, LEU118, VAL127, ILE141, MET143, HIS188, ARG189 and 9 more
- 8BW9 · Cryo-EM structure of the RAF activating complex KSR-MEK-CNK-HYP · QOM C402 · binds LYS116, ILE118, LEU134, LEU137, VAL146, ILE160, MET162, ARG208 and 10 more
- 7JUR · Crystal structure of KSR2:MEK1 in complex with AMP-pnp, and allosteric MEK inhibitor… · QOM C402 · binds PRO878, LYS97, LEU118, VAL127, ILE141, MET143, ARG189, ASP190 and 7 more
- 7JUX · Crystal structure of KSR1:MEK1 in complex with AMP-pnp, and allosteric MEK inhibitor… · QOM C402 · binds LYS97, LEU118, VAL127, ILE141, ASP208, PHE209, GLY210, VAL211 and 4 more
- 7M0Y · Crystal structure of the BRAF:MEK1 kinases in complex with amppnp and trametinib · QOM B404 · binds ASN660, ARG662, LYS97, LEU115, LEU118, VAL127, ILE141, MET143 and 10 more
Residues it binds most
ILE 5, LEU 5, VAL 5, ASP 5, ARG 5, MET 5, GLY 5, LYS 5, PHE 5, SER 5 (residue and the binding sites it lines).
Found with
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