MolNFT v1 · #124630 · protein
KSR2:MEK1 complex bound to the small molecule aps-2-79
5KKR: “KSR2:MEK1 complex bound to the small molecule aps-2-79”. X-ray diffraction, 1 ligand (6U7). MolNFT v1 #124630 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5KKR
- Type
- protein
- Length
- 581 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q6VAB6, P29678
- Ligands
- 6U7
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | — | protein | 272 | — | Q6VAB6 |
| C | — | protein | 309 | — | P29678 |
Ligands and binding sites
- 6U7 · 6,7-dimethoxy-~{N}-(2-methyl-4-phenoxy-phenyl) quinazolin-4-amine · ligand · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5KKR · KSR2:MEK1 Complex Bound to the Small Molecule APS-2-79 · the same entry in another collection · chain B against B, TM-score 1.00
- P29678 · AlphaFold monomer V2.0 prediction for dual specificity mitogen- activated protein kinase… · a predicted model of the same protein · chain C against A, TM-score 0.97
- Q6VAB6 · AlphaFold monomer V2.0 prediction for kinase suppressor of RAS 2 (Q6VAB6) · a predicted model of the same protein · chain B against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6VAB6
- Every structure of UniProt P29678
- Elsewhere: RCSB PDB 5KKR · PDBe 5KKR · UniProt Q6VAB6 · UniProt P29678
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